%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.46099854 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 146.13699341 23.67700005 Tm 0 Tr [(CFLAR)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 208.39900208 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 318.83898926 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CF)-1(LAR)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 115.86399841 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.36399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.61399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CFL)-1(A)1(R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.34700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.72100067 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.3710022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.74499512 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.30400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.67799377 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.47399902 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CASH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.35199738 12.82499981 Tm [(FL)-1(IP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.47000122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97200012 12.82499981 Tm [(MRIT;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.22200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.72399902 12.82499981 Tm [(CL)-1(A)1(RP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.74699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.24899292 12.82499981 Tm [(FL)-1(A)1(ME)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.477005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.97900391 12.82499981 Tm [(Casp)-1(e)1(r;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.92500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.42700195 12.82499981 Tm [(FL)-1(A)1(ME)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.97698975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.47900391 12.82499981 Tm [(c-FL)-1(IP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.25201416 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.7539978 12.82499981 Tm [(FL)-1(A)1(ME)-1(-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.51800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.01998901 12.82499981 Tm [(I-F)-1(LICE;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(c-FL)-1(IP)1(L)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.18700027 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.56100082 30.49699783 Tm [(c-FL)-1(IP)1(R;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.03500366 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.40899658 30.49699783 Tm [(c-FL)-1(IP)1(S)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.0059967 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.37999725 30.49699783 Tm [(CASP8A)1(P1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44599915 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CF)-1(LAR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.61399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.375 0.75 l 422.375 109.94999695 l 155.5249939 109.94999695 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2250061 -0.25 l 268.2250061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.86799622 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.71000671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.21000671 11.72200012 Tm [(ap)1(op)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(to)1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.80200005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.30200005 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.57899857 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.07899857 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.63999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.13999939 27.3220005 Tm [(st)1(ruc)-1(tura)1(ll)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01799774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51799774 27.3220005 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.71299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.21299744 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.28799438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.78799438 27.3220005 Tm [(caspa)1(se)-1(-)1(8)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.7749939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.2749939 27.3220005 Tm [(However,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.60400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.10400391 27.3220005 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.11299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61299896 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41999817 42.92200089 Tm [(lack)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.3690033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.8690033 42.92200089 Tm [(caspa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.51800537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.01800537 42.92200089 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.49000549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.99000549 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.26699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.76699829 42.92200089 Tm [(ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.92100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.42100525 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.4960022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.85400009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35400009 58.52199936 Tm [(itself)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.88999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.38999939 58.52199936 Tm [(cl)-1(eaved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.96700287 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.46700287 58.52199936 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.48300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98300171 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.16400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.66400146 58.52199936 Tm [(pept)1(ides)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.04400635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.54400635 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55599976 58.52199936 Tm [(caspa)1(se)-1(-)1(8)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.54299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.04299927 58.52199936 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.98098755 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.92200089 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.42200089 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.99199677 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.49199677 74.12200165 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.83399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.33399963 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.27400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.77400208 74.12200165 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93400574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.43400574 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.78100586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.28100586 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.78799438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.69000053 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.19000053 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.4679985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.9679985 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.42399979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9240036 89.72200012 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.60600281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.10600281 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.38300323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.88300323 89.72200012 Tm [(pa)1(rtial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.16000366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.66000366 89.72200012 Tm [(eviden)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.91400146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.41400146 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.69200134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.19200134 89.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.10099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.60099792 89.72200012 Tm [(mor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.17599869 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.67599869 105.3219986 Tm [(exists.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.59100342 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2250061 -0.25 l 268.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2250061 -0.25 l 268.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CFLAR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.62800026 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2250061 -0.25 l 268.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CFLAR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.49099731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 0.75 m 155.1499939 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 110.69999695 m 155.1499939 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 127.04999542 m 155.1499939 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 143.3999939 m 155.1499939 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.375 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.375 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.375 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 159.375 m 423.125 159.375 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>