%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 164 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 33.7859993 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 83.46199799 23.67700005 Tm 0 Tr [(CFL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.65699768 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.6309967 23.67700005 Tm [(\(Ph)1(osph)1(o-Ser3\))] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 271.07400513 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 381.51400757 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CF)-1(L1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.78399658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.15799713 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser3)1(\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 174.92700195 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 227.42700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.42700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CFL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.89299774 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.26699829 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser3)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.03599548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.41000366 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05999756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.43400574 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.99299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.36700439 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.16299438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CF)-1(L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.64700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02100372 12.82499981 Tm [(COF)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52799988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.90200043 12.82499981 Tm [(Co)-1(fil)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.98800659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CF)-1(L1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.15899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.53299713 12.82499981 Tm [(\(Pho)-1(spho)-1(-Ser3)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.30200195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 144.2749939 63.15000153 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cont)1(rols)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.36000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.86000061 11.72200012 Tm [(reve)-1(r)1(sibly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.63800049 11.72200012 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.41999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.91999817 11.72200012 Tm [(po)1(l)-1(ymerizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.33500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.83500671 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.11199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.61199951 11.72200012 Tm [(depo)1(l)-1(ymerizat)1(io)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.48699951 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.46199989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.96199989 27.3220005 Tm [(pH-sensitive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.52300262 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.02300262 27.3220005 Tm [(manne)-1(r)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.23200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.73199463 27.3220005 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.73100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23100281 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.91299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.41299438 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.41400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.91400146 27.3220005 Tm [(ab)1(i)-1(lit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.93800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.43800354 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.51300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.01300049 27.3220005 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.45899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.95899963 27.3220005 Tm [(G-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.54501343 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.04501343 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 42.92200089 Tm [(F-actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.25999832 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.75999832 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.70100021 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.20100021 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.1760025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.6760025 42.92200089 Tm [(1:1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.39800262 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.89800262 42.92200089 Tm [(rat)1(io)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.77899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.27899933 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.6210022 42.92200089 Tm [(cofilin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.70700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.20700073 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.28199768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.78199768 42.92200089 Tm [(actin.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.72999573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.22999573 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.22900391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.72900391 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.28999329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.78999329 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.79100037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.29100037 42.92200089 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.26098633 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.68899918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.18899918 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.03099823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.53099823 58.52199936 Tm [(intra)1(n)-1(ucle)-1(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.7539978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.2539978 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.53100586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.03100586 58.52199936 Tm [(cy)-1(t)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.00799561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.50799561 58.52199936 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.28999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.78999329 58.52199936 Tm [(rod)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.03799438 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CFL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.69799995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.19799995 11.72200012 Tm [(\(Pho)1(spho)1(-Ser3)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.06500244 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CFL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.56100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.06100464 11.72200012 Tm [(\(Pho)1(spho)1(-Ser3)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.92799377 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cofilin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08600044 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.58600044 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.86399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.36399841 11.72200012 Tm [(\(non-muscle)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.24199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.74199677 11.72200012 Tm [(\(Pho)1(spho)1(-Ser3)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.60899353 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CFL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.58699989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.08699989 11.72200012 Tm [(COF1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.66799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.16799927 11.72200012 Tm [(Cof)1(il)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.76100159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P23)-1(52)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 161.25 cm q /GS2 gs 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 144.2749939 16.35000038 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.45999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.95999908 11.72200012 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.74499893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.24500275 11.72200012 Tm [(carci)-1(noma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.75299835 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 0.75 m 143.8999939 63.15000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 63.90000153 m 143.8999939 79.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 80.25 m 143.8999939 95.84999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 96.59999847 m 143.8999939 112.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 112.94999695 m 143.8999939 128.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 129.30000305 m 143.8999939 144.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 145.65000916 m 143.8999939 161.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 162.00001526 m 143.8999939 177.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 177.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 112.57499695 m 422.42498779 112.57499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.92500305 m 422.42498779 128.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 145.27500916 m 422.42498779 145.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 161.62501526 m 422.42498779 161.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.97502136 m 423.17498779 177.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>