%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 150 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(EI)1(F4G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.69000244 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.66400146 23.67700005 Tm [(\(p)1(ho)1(spho)1(-Ser)-1(12)1(32\))] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 291.65499878 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 402.09500122 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(EIF)-1(4G)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.48999786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.86399841 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Ser)1(1232\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 200.69000244 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 253.19000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.94000244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EIF4G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.59799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.97200012 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Ser)1(1232\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.79800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.17199707 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.82200623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.19599915 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.75500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.1289978 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.92498779 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(P2)1(20;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.1989975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.57299805 12.82499981 Tm [(EIF)-1(4F;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.12599945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.5 12.82499981 Tm [(EIF)-1(4G)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.852005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.22599792 12.82499981 Tm [(EIF)-1(4G)1(I;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.22399902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.5980072 12.82499981 Tm [(PA)1(RK18)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.70700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.08099365 12.82499981 Tm [(EIF)-1(-4G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.16000366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EIF)-1(4G)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.86499786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.23899841 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Ser)1(1232\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.06500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 155.5249939 172.3500061 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(eIF)-1(4F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.59199905 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.09199905 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.65299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.15299988 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.12799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.62799835 11.72200012 Tm [(multi-sub)1(u)-1(nit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.94300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.44300079 11.72200012 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.08900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.58900452 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.58999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.08999634 11.72200012 Tm [(composit)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.80400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.30400085 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.64599609 11.72200012 Tm [(wh)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55500031 27.3220005 Tm [(var)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.35800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.85800171 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.25400162 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.7539978 27.3220005 Tm [(external)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.23300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.73300171 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.01000214 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.51000214 27.3220005 Tm [(internal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.26199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.76199341 27.3220005 Tm [(en)-1(v)1(i)-1(r)1(onme)-1(nta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.04600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.54600525 27.3220005 Tm [(condit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.99500084 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.49500084 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.49399948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.99399948 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.55500031 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.05500031 42.92200089 Tm [(composed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.22200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.72200012 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.56400299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.06400299 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.39199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.89199829 42.92200089 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.88699341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.38699341 42.92200089 Tm [(EIF4A,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.53900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.03900146 42.92200089 Tm [(EIF4E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.63999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.13999939 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.41700745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.91700745 42.92200089 Tm [(EIF4G1)-1(/)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(EIF4G3)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.79000092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29000092 58.52199936 Tm [(Interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.38400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.88400269 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.27999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.77999878 58.52199936 Tm [(eIF)-1(3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.75800323 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.25800323 58.52199936 Tm [(mutually)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.66400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.16400146 58.52199936 Tm [(exc)-1(lusive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.67799377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.17799377 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.57400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.07400513 58.52199936 Tm [(EIF4A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.93600082 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.43600082 74.12200165 Tm [(EIFA2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58800125 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08800125 74.12200165 Tm [(EIF4E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.68900299 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.18900299 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.46600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.96600342 74.12200165 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.86300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.36300659 74.12200165 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.2769928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.7769928 74.12200165 Tm [(N-t)1(e)-1(r)1(mi)-1(nus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.96899414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.46899414 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.86500549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.36500549 74.12200165 Tm [(PA)1(PB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(C1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.46500015 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.96500015 89.72200012 Tm [(Interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.05899811 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.55899811 89.72200012 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.45600128 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.95600128 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.87000275 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.37000275 89.72200012 Tm [(C-t)1(e)-1(r)1(min)-1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.26600647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.76600647 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.16200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.66200256 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.66299438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.16299438 89.72200012 Tm [(serine)-1(/th)1(re)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.59300041 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.09300041 105.3219986 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.34700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.84700012 105.3219986 Tm [(MKNK1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.82700348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.32700348 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.60399628 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.10399628 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.5 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142 105.3219986 Tm [(MKNK2.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.97999573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.47999573 105.3219986 Tm [(Ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.99200439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.49200439 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.56700134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.06700134 105.3219986 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.90800476 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.40800476 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.14100075 120.92199707 Tm [(scaff)1(old)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.9090004 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.4090004 120.92199707 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.88200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.38200378 120.92199707 Tm [(ho)1(l)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.49500275 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.99499512 120.92199707 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.26800537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.76800537 120.92199707 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.31500244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.81500244 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.7559967 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.2559967 120.92199707 Tm [(place)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.99299622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.49299622 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.56799316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.2179985 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.71800232 136.52200317 Tm [(EIF4E.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.48600006 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.98600006 136.52200317 Tm [(Non-p)1(hosp)1(horylat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.43899536 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.93899536 136.52200317 Tm [(EIF4EB)-1(P)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.97099304 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.47099304 136.52200317 Tm [(comp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(etes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.73200035 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.23200035 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.62799835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.12799835 152.12199402 Tm [(EIF4G1)-1(/EI)1(F)-1(4G3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.22000122 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.72000122 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.79499817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.29499817 152.12199402 Tm [(interact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.9730072 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.4730072 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8690033 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.3690033 152.12199402 Tm [(EIF4E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.13699341 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.63699341 152.12199402 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.62600708 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.12600708 152.12199402 Tm [(st)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(mulated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56499863 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.06499863 167.72200012 Tm [(MAP)1(-k)-1(inas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.67900085 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.17900085 167.72200012 Tm [(\(MAP)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.80799866 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.30799866 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.58500671 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.08500671 167.72200012 Tm [(MAP)1(K3)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.71400452 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.21400452 167.72200012 Tm [(ph)1(osph)1(orylati)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 0.75 m 155.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>