%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 135 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 107.03099823 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 156.70700073 23.67700005 Tm 0 Tr [(CFH)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 197.82800293 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 308.26800537 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CF)-1(H)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.71499634 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 148.21499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.71499634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CFH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.69799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.0719986 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.72200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.09599304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.65499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.02900696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.82499695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(compl)-1(e)1(ment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.16100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.63800049 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.0269928 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.5039978 12.82499981 Tm [(H;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.85600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.33299255 12.82499981 Tm [(FH)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.50900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.98599243 12.82499981 Tm [(HF)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.16200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.63900757 12.82499981 Tm [(HF)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.13699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.61399841 12.82499981 Tm [(HF)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.11199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.58900452 12.82499981 Tm [(HUS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.50201416 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.97900391 12.82499981 Tm [(FH)-1(L1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.89099121 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.36801147 12.82499981 Tm [(AHU)1(S)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.67800903 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.15499878 12.82499981 Tm [(AMBP)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.4750061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 379.95199585 12.82499981 Tm [(ARMD4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(ARMS1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.70999908 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.08399963 30.49699783 Tm [(CF)-1(HL3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.78499985 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CF)-1(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.96499634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 151.0249939 0.75 l 151.0249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 152.0249939 -0.25 l 152.0249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.7749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 151.7749939 156.75 l h f* Q q 1 0 0 1 151.3999939 0 cm -0.625 -0.25 m 272.0249939 -0.25 l 272.0249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(Regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.08700562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.58700562 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.42900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.92900085 11.72200012 Tm [(Comp)1(le)-1(ment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.79199219 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(Activa)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.30799866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.80799866 27.3220005 Tm [(\(RCA)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.04799652 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.54799652 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.06400299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.56400299 27.3220005 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.08000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.58000183 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.85699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.35699463 27.3220005 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.27400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.77400208 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.74899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.24899292 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05599976 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.45199585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tw)1(en)-1(t)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.22800064 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72800064 42.92200089 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.9469986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.4469986 42.92200089 Tm [(conse)-1(nsus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.9240036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.4240036 42.92200089 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.14900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.64900208 42.92200089 Tm [(\(SCR\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.75100708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.25100708 42.92200089 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.41099548 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.91099548 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.17300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.67300415 42.92200089 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 58.52199936 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.65200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.15200043 58.52199936 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.16799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.66799927 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66899872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.16899872 58.52199936 Tm [(bloo)1(dst)1(re)-1(a)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.98199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.48199463 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.75900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.25900269 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.94099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.44099426 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.96200562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.46200562 58.52199936 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.66999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.17001343 58.52199936 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ole)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.22299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.72299957 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.66399956 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.16399956 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.16500092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.66500092 74.12200165 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.89600372 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.39600372 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.23799896 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.73799896 74.12200165 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.09399414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.59399414 74.12200165 Tm [(activat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.71099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.21099854 74.12200165 Tm [(restricting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.66900635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 89.72200012 Tm [(inn)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.8769989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.3769989 89.72200012 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.28500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.78500366 89.72200012 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.89399719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.39399719 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.46899414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.96899414 89.72200012 Tm [(mic)-1(r)1(obial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.98100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.48100281 89.72200012 Tm [(infec)-1(t)1(i)-1(o)1(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.50999451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.00999451 89.72200012 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(utat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.05500031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.55500031 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.49599838 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.99599838 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.45200348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.95200348 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.46800232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.96800232 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.31500244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.81500244 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.32200623 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.82200623 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.94900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.44900513 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.84500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.34500122 105.3219986 Tm [(hemolytic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(-uremic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.32400131 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.82400131 120.92199707 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.7539978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.2539978 120.92199707 Tm [(\(HUS\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.13999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.63999939 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.91700745 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.41700745 120.92199707 Tm [(chronic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.08399963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.58399963 120.92199707 Tm [(hypo)1(c)-1(omp)1(le)-1(mentemi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.51300001 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.01299953 136.52200317 Tm [(ne)-1(p)1(hrop)1(ath)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.66000366 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.16000366 136.52200317 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.76399994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.26399994 136.52200317 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.21800232 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.71800232 136.52200317 Tm [(splice)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.04200745 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.54200745 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.27799988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.77799988 136.52200317 Tm [(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(coding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.68899918 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.18899918 152.12199402 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.1289978 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.6289978 152.12199402 Tm [(isof)1(orms,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.95600128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.45600128 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.80299377 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.30299377 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.80999756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.30999756 152.12199402 Tm [(chara)1(c)-1(terized.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.00999451 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.3999939 0.75 m 151.3999939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>