%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 110 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(EI)1(F4EBP2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 138.94400024 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 249.38400269 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 260.38400269 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -57.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -33.875 61.9640007 Tm [(EIF)-1(4EBP)1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 8.25299835 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 60.75300598 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.00300598 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EIF4EBP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.23699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.61100006 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.26100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.63499451 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.19400024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.56799316 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.36399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(4EBP2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.71600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.08999634 12.82499981 Tm [(PHA)1(S)-1(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.24700165 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EIF)-1(4EBP)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.50299835 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 160.0249939 0.75 l 160.0249939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 161.0249939 -0.25 l 161.0249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 160.7749939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 160.7749939 141.1499939 l h f* Q q 1 0 0 1 160.3999939 0 cm -0.625 -0.25 m 263.0249939 -0.25 l 263.0249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.98699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.48699951 11.72200012 Tm [(tr)1(anslati)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 27.3220005 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.84199905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.34199905 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.46099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.96099854 27.3220005 Tm [(4E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.18699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.68699646 27.3220005 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.83099365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.33099365 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.63800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.13800049 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.38600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.88600159 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.69299316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.19299316 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.70899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.24100113 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.74100113 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.58300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.08300018 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.53900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.03900146 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.1210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.6210022 42.92200089 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.06700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.56700134 42.92200089 Tm [(eIF)-1(4E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.32600403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.82600403 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.10299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.60299683 42.92200089 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.977005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.477005 42.92200089 Tm [(tr)1(anslatio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(initiat)1(i)-1(o)1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.28699875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.78699875 58.52199936 Tm [(However,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.11599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.61599731 58.52199936 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.60500336 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.10499573 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.38200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.88200378 58.52199936 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.04100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.54100037 58.52199936 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.45700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.95700073 58.52199936 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.24200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.74200439 58.52199936 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.52099991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02099991 74.12200165 Tm [(rele)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.31299973 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.81299973 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.26899719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.76899719 74.12200165 Tm [(inhibitio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.80500031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.30500031 74.12200165 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.39900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.89900208 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.87399292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.37399292 74.12200165 Tm [(ph)1(osph)1(orylation-)1(depen)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 89.72200012 Tm [(disr)1(u)-1(p)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.46300125 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.96300125 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.80500031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.30500031 89.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.13800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.63800049 89.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.78199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.28199768 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.35699463 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.85699463 89.72200012 Tm [(eIF)-1(4E.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.78300476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.28300476 89.72200012 Tm [(Regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.95300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.45300293 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.29499817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.79499817 89.72200012 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 105.3219986 Tm [(pro)1(duc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.36000061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.86000061 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.75700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.25700378 105.3219986 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.52999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.02999878 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.54600525 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.04600525 105.3219986 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.28700256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.78700256 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.13400269 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.63400269 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.65200043 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15200043 120.92199707 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.22200012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72200012 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.66300201 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.16300201 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.57299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.07299805 120.92199707 Tm [(pro)1(life)-1(r)1(ation,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.58900452 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.08900452 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.49899292 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.99899292 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.32499695 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.82499695 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 136.52200317 Tm [(viral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.18199921 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.68199921 136.52200317 Tm [(infec)-1(t)1(i)-1(o)1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.54499817 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q 1 g 0.375 0.75 m 160.0249939 0.75 l 160.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.0249939 -0.25 l 161.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 160.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 160.7749939 16.35000038 l h f* Q q 1 0 0 1 160.3999939 0 cm -0.625 -0.25 m 263.0249939 -0.25 l 263.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q 1 g 0.375 0.75 m 160.0249939 0.75 l 160.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.0249939 -0.25 l 161.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 160.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 160.7749939 16.35000038 l h f* Q q 1 0 0 1 160.3999939 0 cm -0.625 -0.25 m 263.0249939 -0.25 l 263.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(EIF4EB)-1(P)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.0320015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.3999939 0.75 m 160.3999939 141.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.3999939 141.8999939 m 160.3999939 157.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.3999939 158.25 m 160.3999939 173.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>