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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 9.29899979 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 58.97499847 23.67700005 Tm 0 Tr [(EI)1(F4EBP1\()1(Phosp)1(ho)1(-)-1(Th)1(r)-1(37)1(\))] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 295.56100464 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 406.00100708 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(EIF)-1(4EBP)1(1\(Pho)-1(sph)-1(o-Th)-1(r)1(37\))] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 187.30299377 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 239.80299377 12.82499981 Tm [(    )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 260.80300903 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EIF4EBP1\(Phosp)-1(ho)-1(-Thr37\))] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 194.91099548 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 197.28500366 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 222.93499756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 225.30900574 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 268.86801147 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 271.24200439 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 309.03799438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BP-1;)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 85.48200226 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 87.85600281 12.82499981 Tm [(4EBP1;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 117.5719986 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 119.94599915 12.82499981 Tm [(4E-BP1;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 152.87600708 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 155.25 12.82499981 Tm [(PHA)1(S)-1(-I)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 183.97599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0011000D>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EIF)-1(4EBP)1(1\(Pho)-1(sph)-1(o-Th)-1(r)1(37\))] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 174.17799377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E000F000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001F0004>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001E0027000D>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 75 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 148.7749939 0.75 l 148.7749939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 149.7749939 -0.25 l 149.7749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.5249939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 149.5249939 156.75 l h f* Q q 1 0 0 1 149.1499939 0 cm -0.625 -0.25 m 274.2749939 -0.25 l 274.2749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(one)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 104.56900024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 109.06900024 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 145.33299255 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 149.83299255 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 158.67500305 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 163.17500305 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 168.1499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 172.6499939 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 198.73199463 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 203.23199463 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 212.07400513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 216.57400513 11.72200012 Tm [(tr)1(anslatio)1(n)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 262.43499756 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(repressor)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 40.32400131 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 44.82400131 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 82.46299744 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 86.96299744 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 102.76999664 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 107.26999664 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 138.57699585 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 143.07699585 27.3220005 Tm [(directly)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 174.79699707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 179.29699707 27.3220005 Tm [(interacts)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 216.14100647 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 220.64100647 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 239.03700256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 243.53700256 27.3220005 Tm [(eu)-1(ka)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ryot)1(i)-1(c)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 24.18300056 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 28.68300056 42.92200089 Tm [(tr)1(anslatio)1(n)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 74.54399872 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 79.04399872 42.92200089 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 117.11799622 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 121.61799622 42.92200089 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 146.73699951 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 151.23699951 42.92200089 Tm [(4E)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 161.46299744 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 165.96299744 42.92200089 Tm [(\(eIF)-1(4E\),)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 196.90100098 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 201.40100098 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 226.4980011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 230.9980011 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 237.55900574 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 242.05900574 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 247.03399658 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 251.53399658 42.92200089 Tm [(lim)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(iting)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 19.44599915 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 23.94599915 58.52199936 Tm [(component)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 73.63500214 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 78.13500214 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 86.97699738 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 91.47699738 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 105.47799683 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 109.97799683 58.52199936 Tm [(multisubunit)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 164.3999939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 168.8999939 58.52199936 Tm [(complex)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 205.3789978 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 209.8789978 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 227.10099792 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 231.60099792 58.52199936 Tm [(rec)-1(ruit)1(s)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 263.5539856 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(40)-1(S)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 15.75 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 20.25 74.12200165 Tm [(ribo)1(somal)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 63.24200058 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 67.74199677 74.12200165 Tm [(subunits)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 104.20800018 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 108.70800018 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 117.78299713 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 122.28299713 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 136.28399658 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 140.78399658 74.12200165 Tm [(5')] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 148.3690033 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 152.8690033 74.12200165 Tm [(en)-1(d)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 169.27799988 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 173.77799988 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 182.61999512 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 187.11999512 74.12200165 Tm [(mRNA)1(s.)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 221.41099548 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 225.91099548 74.12200165 Tm [(Interacti)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(on)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 11.26799965 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 15.76799965 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 24.61000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 29.11000061 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 44.56600189 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 49.06600189 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 80.3730011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 84.8730011 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 103.26899719 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 107.76899719 89.72200012 Tm [(eIF)-1(4E)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 130.52799988 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 135.02799988 89.72200012 Tm [(inhibits)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 166.56799316 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 171.06799316 89.72200012 Tm [(complex)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 207.54699707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 212.04699707 89.72200012 Tm [(assembly)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 251.80000305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 256.29998779 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nd)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 11.30300045 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 15.80300045 105.3219986 Tm [(represses)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 56.24100113 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 60.74100113 105.3219986 Tm [(tr)1(anslatio)1(n)-1(.)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 108.76899719 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 113.26899719 105.3219986 Tm [(This)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 130.53100586 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 135.03100586 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 166.33799744 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 170.83799744 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 177.39900208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 181.89900208 105.3219986 Tm [(ph)1(osph)1(orylated)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 249.87399292 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 254.37399292 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 262.31500244 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(response)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 38.99700165 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 43.49700165 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 52.5719986 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 57.0719986 120.92199707 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 88.03600311 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 92.53600311 120.92199707 Tm [(signals)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 121.93499756 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 126.43499756 120.92199707 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 166.28500366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 170.78500366 120.92199707 Tm [(UV)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 183.59100342 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 188.09100342 120.92199707 Tm [(irrad)1(iatio)1(n)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 232.47599792 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 236.97599792 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 253.25300598 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 257.75299072 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(sulin)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 20.04800034 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 24.54800034 136.52200317 Tm [(signaling,)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 65.64600372 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 70.14600372 136.52200317 Tm [(resulting)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 107.84700012 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 112.34700012 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 120.28800201 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 124.78800201 136.52200317 Tm [(its)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 134.70199585 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 139.20199585 136.52200317 Tm [(disso)1(c)-1(iat)1(ion)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 190.30599976 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 194.80599976 136.52200317 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 215.51699829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 220.01699829 136.52200317 Tm [(eIF)-1(4E)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 242.77600098 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 247.27600098 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 263.55300903 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 41.95000076 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 46.45000076 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 55.29199982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 59.79199982 152.12199402 Tm [(mRNA)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 87.75 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 92.25 152.12199402 Tm [(tr)1(anslatio)1(n)-1(.)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 140.27799988 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 148.7749939 0.75 l 148.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.7749939 -0.25 l 149.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 248 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 249 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.5249939 16.35000038 l h f* Q q 1 0 0 1 149.1499939 0 cm -0.625 -0.25 m 274.2749939 -0.25 l 274.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 250 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.1499939 0.75 m 149.1499939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.1499939 157.5 m 149.1499939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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