%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 46.26800156 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 95.94400024 23.67700005 Tm 0 Tr [(EI)1(F4EBP1\()1(Ab-64\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.59100342 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 258.59100342 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 369.03100586 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(EIF)-1(4EBP)1(1\(Ab-)-1(6)1(4\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.44599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 152.69599915 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 205.19599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.44599915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EIF4EBP1\(Ab-64\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.05400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.42799377 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.07800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.45199585 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.01100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.38499451 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.18099976 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BP-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.48200226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.85600281 12.82499981 Tm [(4EBP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.5719986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.94599915 12.82499981 Tm [(4E-BP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.87600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.25 12.82499981 Tm [(PHA)1(S)-1(-I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.97599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EIF)-1(4EBP)1(1\(Ab-)-1(6)1(4\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.32099915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.375 0.75 l 422.375 109.94999695 l 164.5249939 109.94999695 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2250061 -0.25 l 259.2250061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.56900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.06900024 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.33299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.83299255 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.67500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.17500305 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.1499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.6499939 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.73199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.23199463 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.57400513 11.72200012 Tm [(tr)1(anslat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 27.3220005 Tm [(repressor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.48699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.98699951 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.62599945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.12599945 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.93299866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.43299866 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.74000549 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.24000549 27.3220005 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.96000671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.46000671 27.3220005 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.30400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.80400085 27.3220005 Tm [(wi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89500046 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39500046 42.92200089 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.10499954 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.60499954 42.92200089 Tm [(tr)1(anslatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.46600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.96600342 42.92200089 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.03999329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.53999329 42.92200089 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.65899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.15899658 42.92200089 Tm [(4E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.38499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.88499451 42.92200089 Tm [(\(eIF)-1(4E\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.82299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.32299805 42.92200089 Tm [(wh)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05500031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55500031 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.11599922 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.61599922 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.5909996 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.0909996 58.52199936 Tm [(limiting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.76000214 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.26000214 58.52199936 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.9489975 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.4489975 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.79100037 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.79200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.29200745 58.52199936 Tm [(multisubunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.71400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.21400452 58.52199936 Tm [(comple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.5619998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.06200027 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.2840004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.7840004 74.12200165 Tm [(rec)-1(ruit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.73699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.23699951 74.12200165 Tm [(40)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.98699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.48699951 74.12200165 Tm [(ribo)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.47900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.97900391 74.12200165 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.44500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.94500732 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.02000427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.52000427 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.52099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.02099609 74.12200165 Tm [(5')] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.60600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.10600281 74.12200165 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.51499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.01499939 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.85699463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mRNA)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.29100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.79100037 89.72200012 Tm [(Interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.38200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.88200378 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.72399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.22399902 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.68000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.18000031 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.48699951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.98699951 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.38299561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.88299561 89.72200012 Tm [(eIF)-1(4E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.64199829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.14199829 89.72200012 Tm [(inhibits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.68200684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.18200684 89.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(omp)1(l)-1(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9659996 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.4659996 105.3219986 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.21900177 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.71900177 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.9960022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.4960022 105.3219986 Tm [(represses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.93400574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.43400574 105.3219986 Tm [(tr)1(anslatio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.46200562 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 164.5249939 16.35000038 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2250061 -0.25 l 259.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 164.5249939 16.35000038 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2250061 -0.25 l 259.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(EIF4EB)-1(P)1(1)-1(\(Ab)1(-64)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.5739975 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.375 0.75 l 422.375 31.95000076 l 164.5249939 31.95000076 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2250061 -0.25 l 259.2250061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.35400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.85400009 11.72200012 Tm [(non-p)1(hosp)1(hopept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.46299744 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.74499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.24499512 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.95599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.45599365 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.49699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(4E-BP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.5510006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.05099869 27.3220005 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.03199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.53199768 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.53299713 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.03299713 27.3220005 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.80700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.30700684 27.3220005 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.32800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.82800293 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.66999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.16999817 27.3220005 Tm [(serine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.92599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.42599487 27.3220005 Tm [(65)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.98199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.48199463 27.3220005 Tm [(\()] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 0.75 m 164.1499939 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 110.69999695 m 164.1499939 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 127.04999542 m 164.1499939 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 143.3999939 m 164.1499939 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.375 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.375 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.375 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97499084 m 423.125 174.97499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>