%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.21399689 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.88999939 23.67700005 Tm 0 Tr [(CES4A)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 208.64599609 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.08599854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CES)-1(4A)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.1969986 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.69700623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.94700623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CES)-1(4)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.68099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.05500031 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.70500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.07899475 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.63800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.01199341 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.80799866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CES)-1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.68099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.05500031 12.82499981 Tm [(CES)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.92700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CES)-1(4A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.9469986 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.375 0.75 l 422.375 172.3500061 l 154.7749939 172.3500061 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 268.9750061 -0.25 l 268.9750061 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(carbo)1(xy)-1(lestera)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80700684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.30700684 11.72200012 Tm [(lar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.11100006 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.91799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.41799927 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99 27.3220005 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.92999268 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.44799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.94799805 27.3220005 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.48300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.98300171 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.26100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.76100159 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.76199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.26199341 27.3220005 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ydrolysis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.56399918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.06399918 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.22200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.72200012 42.92200089 Tm [(tr)1(anse)-1(st)1(erific)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.77999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.27999878 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.12199402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.62199402 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.08599854 42.92200089 Tm [(xenobiot)1(ic)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.47999573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.97999573 42.92200089 Tm [(suc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18300056 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68300056 58.52199936 Tm [(coc)-1(a)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.45299911 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.95299911 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.23000336 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.73000336 58.52199936 Tm [(heroin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.64399719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14399719 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.42100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.92100525 58.52199936 Tm [(en)-1(d)1(ogenous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.89500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.39500427 58.52199936 Tm [(subst)1(rat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.41099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.91099548 58.52199936 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 74.12200165 Tm [(ester,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.3769989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.8769989 74.12200165 Tm [(th)1(ioe)-1(s)1(ter,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.22299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.72299957 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.8809967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.3809967 74.12200165 Tm [(amide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.54699707 74.12200165 Tm [(bo)1(n)-1(d)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.6519928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.1519928 74.12200165 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.7230072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.2230072 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.47999573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.97999573 74.12200165 Tm [(pa)1(rticipat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.97799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 89.72200012 Tm [(fa)1(tty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00500107 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.50500107 89.72200012 Tm [(acyl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.15100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.65100098 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.9280014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.4280014 89.72200012 Tm [(cholesterol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.88500214 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.38499451 89.72200012 Tm [(ester)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.55299377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.05299377 89.72200012 Tm [(metab)1(olism,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.94599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.44599915 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.7230072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.2230072 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.39399719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.88100052 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.38100052 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.3560009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.8560009 105.3219986 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.51599884 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.95700073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.45700073 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.45800018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.95800018 105.3219986 Tm [(bloo)1(d-b)1(rain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.29499817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.79499817 105.3219986 Tm [(ba)1(rrie)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.32899475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.82899475 105.3219986 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.98399353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.48399353 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.7460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.2460022 105.3219986 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.92799377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.25699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.75699997 120.92199707 Tm [(calle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.89799881 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.39799881 120.92199707 Tm [(CES6,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.00499725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.50499725 120.92199707 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.42199707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.92199707 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.89700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.39700317 120.92199707 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.94200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.44200134 120.92199707 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.98899841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.48899841 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.76600647 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.26600647 120.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.43699646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.93699646 120.92199707 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(lay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.13300037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.63299942 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.6079998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.1079998 136.52200317 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.76800156 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.26800156 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.20899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.70899963 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.70999908 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.20999908 136.52200317 Tm [(deto)1(xific)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.1230011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.6230011 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.46499634 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.96499634 136.52200317 Tm [(dr)1(u)-1(g)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.6269989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.1269989 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.40400696 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.90400696 136.52200317 Tm [(xenobiot)1(ic)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.13200378 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 152.12199402 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.44499969 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.94499969 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.22200012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72200012 152.12199402 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.8809967 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.3809967 152.12199402 Tm [(tiss)1(u)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.27899933 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.77899933 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.6210022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.1210022 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.12199402 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.62199402 152.12199402 Tm [(bo)1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.61199951 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.11199951 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.38900757 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.88900757 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.83000183 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.33000183 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.33099365 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.83099365 152.12199402 Tm [(ce)-1(reb)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ros)1(pinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.38299942 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.88299942 167.72200012 Tm [(fluid.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.26200104 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.76200104 167.72200012 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.4940033 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.9940033 167.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.91600037 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.41600037 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.98599243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.48599243 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.82800293 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.32800293 167.72200012 Tm [(dif)1(fe)-1(r)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 0.75 m 154.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.125 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>