%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 146 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 13.09599972 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 62.77199936 23.67700005 Tm 0 Tr [(EI)1(F4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9489975 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.92299652 23.67700005 Tm [(\(p)1(ho)1(spho)1(-Ser)-1(42)1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.76400757 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 291.76400757 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 402.20401001 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(EIF)-1(4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25499725 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.6289978 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Ser)1(422\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.13299561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 194.38299561 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 246.88299561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.63299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EIF4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.36399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.73799896 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Ser)1(422\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.24200439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.61599731 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.26600647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.63999939 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.19900513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.57299805 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.36898804 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EIF)-1(-4B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.65399933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.02799988 12.82499981 Tm [(PRO18)1(43)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.39300537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EIF)-1(4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.62999725 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.0039978 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Ser)1(422\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.50799561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 165.2749939 0.75 l 165.2749939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 166.2749939 -0.25 l 166.2749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.0249939 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 166.0249939 94.34999847 l h f* Q q 1 0 0 1 165.6499939 0 cm -0.625 -0.25 m 257.7749939 -0.25 l 257.7749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.97900009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.47900009 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.75699997 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.25699997 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.25800323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75800323 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.90200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.40200043 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.2440033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.7440033 11.72200012 Tm [(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.70199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.20199585 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.2769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.7769928 11.72200012 Tm [(ribo)1(somes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.83799744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.33799744 11.72200012 Tm [(Fun)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tio)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.18199921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.68199921 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.6230011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.1230011 27.3220005 Tm [(cl)-1(o)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.02500153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.52500153 27.3220005 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.45200348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.95200348 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.3480072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.8480072 27.3220005 Tm [(EIF4-F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.17599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.67599487 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.95300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.45300293 27.3220005 Tm [(EIF4-A.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.4980011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.9980011 27.3220005 Tm [(Bi)-1(nd)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.50900269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ne)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.06299973 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.56299973 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.56399918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.06399918 42.92200089 Tm [(5')-1(-)1(termin)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.18199921 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.68199921 42.92200089 Tm [(cap)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.91799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.41799927 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.26000214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.76000214 42.92200089 Tm [(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.71800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.21800232 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.15899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.65899658 42.92200089 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.38800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.88800049 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.72999573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.22999573 42.92200089 Tm [(EIF-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(4F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05900002 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55900002 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.83600044 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.33599854 58.52199936 Tm [(ATP.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.50099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.00099945 58.52199936 Tm [(Pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.44599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.94599915 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.9469986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.4469986 58.52199936 Tm [(ATPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.69200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.19200134 58.52199936 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.66400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.16400146 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.44099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.94099426 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.94200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.44200134 58.52199936 Tm [(AT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(P-)1(depe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.42599869 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.92599869 74.12200165 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.4509964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.9509964 74.12200165 Tm [(unwinding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.54400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.04400635 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.51600647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.01600647 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.85800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.35800171 74.12200165 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.72200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.22200012 74.12200165 Tm [(EIF4-A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.10099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.60099792 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 89.72200012 Tm [(EIF4-F.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.29700089 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 165.2749939 0.75 l 165.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.2749939 -0.25 l 166.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.0249939 16.35000038 l h f* Q q 1 0 0 1 165.6499939 0 cm -0.625 -0.25 m 257.7749939 -0.25 l 257.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 165.2749939 0.75 l 165.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.2749939 -0.25 l 166.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.0249939 16.35000038 l h f* Q q 1 0 0 1 165.6499939 0 cm -0.625 -0.25 m 257.7749939 -0.25 l 257.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(EIF4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.29999924 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.79999924 11.72200012 Tm [(\(ph)1(osph)1(o-Ser4)-1(22\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.46499634 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 165.2749939 0.75 l 165.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 166.2749939 -0.25 l 166.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.0249939 16.35000038 l h f* Q q 1 0 0 1 165.6499939 0 cm -0.625 -0.25 m 257.7749939 -0.25 l 257.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(EIF4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.16299438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.66299438 11.72200012 Tm [(\(ph)1(osph)1(o-Ser4)-1(22\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.32800293 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 165.2749939 0.75 l 165.2749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 166.2749939 -0.25 l 166.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.0249939 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 166.0249939 31.95000076 l h f* Q q 1 0 0 1 165.6499939 0 cm -0.625 -0.25 m 257.7749939 -0.25 l 257.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.70999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.20999908 11.72200012 Tm [(tr)1(anslatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.07099915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.57099915 11.72200012 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.64500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.14500427 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.26400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.76400757 11.72200012 Tm [(4B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.68899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.18899536 11.72200012 Tm [(\(ph)1(osph)1(o-Ser)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(42)-1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.8390007 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.34999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 165.6499939 0.75 m 165.6499939 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 165.6499939 95.09999847 m 165.6499939 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 165.6499939 111.44999695 m 165.6499939 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 165.6499939 127.79999542 m 165.6499939 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 165.6499939 144.1499939 m 165.6499939 175.34999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.34999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.72499084 m 423.17498779 175.72499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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