%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 161 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 102.8789978 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 152.55499268 23.67700005 Tm 0 Tr [(CES2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 201.97999573 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 312.42001343 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CES)-1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 110.12200165 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 162.62199402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.62199402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CES)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.60500336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.97899628 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.6289978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.00300598 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.56199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.93600464 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.73199463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(car)1(b)-1(oxylester)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.98800659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.36199951 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.49299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.86700439 12.82499981 Tm [(iC)-1(E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.81199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.18600464 12.82499981 Tm [(CE-)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.25799561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.63200378 12.82499981 Tm [(PCE-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.12800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.5019989 12.82499981 Tm [(CES)-1(2A)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.77099609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CES)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.87200165 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 155.5249939 0.75 l 155.5249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 156.5249939 -0.25 l 156.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.2749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 156.2749939 156.75 l h f* Q q 1 0 0 1 155.8999939 0 cm -0.625 -0.25 m 267.5249939 -0.25 l 267.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(carbo)1(xy)-1(lestera)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80700684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.30700684 11.72200012 Tm [(lar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.11100006 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.91799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.41799927 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99 27.3220005 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.92999268 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.44799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.94799805 27.3220005 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.48300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.98300171 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.26100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.76100159 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.76199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.26199341 27.3220005 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ydrolysis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.56399918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.06399918 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.22200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.72200012 42.92200089 Tm [(tr)1(anse)-1(st)1(erific)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.77999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.27999878 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.12199402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.62199402 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.08599854 42.92200089 Tm [(xenobiot)1(ic)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.47999573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.97999573 42.92200089 Tm [(suc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18300056 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68300056 58.52199936 Tm [(coc)-1(a)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.45299911 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.95299911 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.23000336 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.73000336 58.52199936 Tm [(heroin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.64399719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14399719 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.42100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.92100525 58.52199936 Tm [(en)-1(d)1(ogenous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.89500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.39500427 58.52199936 Tm [(subst)1(rat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.41099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.91099548 58.52199936 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 74.12200165 Tm [(ester,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.3769989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.8769989 74.12200165 Tm [(th)1(ioe)-1(s)1(ter,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.22299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.72299957 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.8809967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.3809967 74.12200165 Tm [(amide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.54699707 74.12200165 Tm [(bo)1(n)-1(d)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.6519928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.1519928 74.12200165 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.7230072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.2230072 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.39399719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.89399719 74.12200165 Tm [(pa)1(rticipat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.89199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 89.72200012 Tm [(fa)1(tty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00500107 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.50500107 89.72200012 Tm [(acyl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.15100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.65100098 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.9280014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.4280014 89.72200012 Tm [(cholesterol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.88500214 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.38499451 89.72200012 Tm [(ester)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.55299377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.05299377 89.72200012 Tm [(metab)1(olism,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.94599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.44599915 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.7230072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.2230072 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.39399719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.88100052 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.38100052 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.3560009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.8560009 105.3219986 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.51599884 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.95700073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.45700073 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.45800018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.95800018 105.3219986 Tm [(bloo)1(d-b)1(rain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.29499817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.79499817 105.3219986 Tm [(ba)1(rrie)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.32899475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.82899475 105.3219986 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.98399353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.48399353 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.29100037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.79100037 105.3219986 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 120.92199707 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.5530014 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.0530014 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.56499863 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.06500244 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.52100372 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.02100372 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.53700256 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.03700256 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.59799957 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.09799957 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.09899902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.59899902 120.92199707 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.56900024 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.06900024 120.92199707 Tm [(intestinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.29899597 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.79899597 120.92199707 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.17999268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.67999268 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 136.52200317 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.70999908 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.20999908 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.15100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.65100098 136.52200317 Tm [(intestine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.61799622 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.11799622 136.52200317 Tm [(dr)1(u)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.61399841 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.11399841 136.52200317 Tm [(cl)-1(eara)1(nc)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.84599304 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.34599304 136.52200317 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.227005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.727005 136.52200317 Tm [(spl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ic)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.77099991 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.27099991 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.19300079 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.69300079 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.26300049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.76300049 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.11000061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.61000061 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.11700439 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.61700439 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.30700684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.80700684 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.08500671 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.58500671 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.04100037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.54100037 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.2230072 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 155.5249939 0.75 l 155.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.5249939 -0.25 l 156.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 156.2749939 16.35000038 l h f* Q q 1 0 0 1 155.8999939 0 cm -0.625 -0.25 m 267.5249939 -0.25 l 267.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.8999939 0.75 m 155.8999939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.8999939 157.5 m 155.8999939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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