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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 110 0 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(CERK)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 101.96900177 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 212.40899658 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 4 >> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT 1 0 0 -1 -57.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -33.875 61.9640007 Tm [(CERK)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -9.36799622 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 43.13200378 61.9640007 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 48.38200378 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CERK)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 105.61499786 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 107.98899841 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 133.63900757 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 136.01300049 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 179.57200623 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 181.94599915 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 219.74200439 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(LK4;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 81.00099945 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 83.375 12.82499981 Tm [(hC)-1(ERK)1(;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 113.58300018 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 115.95700073 12.82499981 Tm [(dA59H18)1(.)-1(2;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 166.16000366 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 168.53399658 12.82499981 Tm [(dA59H18)1(.)-1(3)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 215.92799377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CERK)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 84.88200378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 76 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 165.5249939 -0.25 l 165.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 165.2749939 156.75 l h f* Q q 1 0 0 1 164.8999939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(CERK)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 22.55699921 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 27.05699921 11.72200012 Tm [(conve)-1(rt)1(s)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63.62400055 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 68.12400055 11.72200012 Tm [(ce)-1(ra)1(mi)-1(d)1(e)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 107.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 112.34600067 11.72200012 Tm [(to)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 121.42099762 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 125.92099762 11.72200012 Tm [(ce)-1(ra)1(mi)-1(d)1(e)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 165.64300537 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 170.14300537 11.72200012 Tm [(1-ph)1(osph)1(ate)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 225.21499634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 229.71499634 11.72200012 Tm [(\(C1P)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(\),)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 5.17199993 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 9.67199993 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 14.64700031 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 19.14699936 27.3220005 Tm [(sph)1(in)-1(g)1(olipid)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 72.71199799 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 77.21199799 27.3220005 Tm [(metab)1(olite.)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 125.96499634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 130.46499634 27.3220005 Tm [(Both)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 150.72799683 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 155.22799683 27.3220005 Tm [(CERK)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 177.78500366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 182.28500366 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 198.56199646 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 203.06199646 27.3220005 Tm [(C1P)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 219.86700439 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 224.36700439 27.3220005 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 244.71400452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(been)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 21.50699997 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 26.00699997 42.92200089 Tm [(implicated)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 71.07700348 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 75.57700348 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 83.51799774 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 88.01799774 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 118.98200226 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 123.48200226 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 154.2440033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 158.7440033 42.92200089 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 203.04100037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 207.54100037 42.92200089 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 247.39100647 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(life)-1(r)1(ation,)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 55.51599884 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 60.01599884 58.52199936 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 104.17700195 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 108.67700195 58.52199936 Tm [(ph)1(agocytos)1(i)-1(s)1(,)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 167.66499329 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 172.16499329 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 188.44200134 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 192.94200134 58.52199936 Tm [(inflammat)1(ion)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(.)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 2.16700006 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 6.66699982 74.12200165 Tm [(Cat)1(alyzes)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 46.84600067 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 51.34600067 74.12200165 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 97.83100128 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 102.33100128 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 116.33200073 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 120.83200073 74.12200165 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 191.60600281 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 196.10600281 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 204.94799805 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 209.44799805 74.12200165 Tm [(ce)-1(ra)1(mi)-1(d)1(e)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 249.16999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 9.07499981 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 13.57499981 89.72200012 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 34.2859993 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 38.7859993 89.72200012 Tm [(ce)-1(ra)1(mi)-1(d)1(e)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 78.50800323 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 83.00800323 89.72200012 Tm [(1-ph)1(osph)1(ate.)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 140.24699402 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 144.74699402 89.72200012 Tm [(Acts)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 163.11199951 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 167.61199951 89.72200012 Tm [(efficie)-1(ntly)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 209.42599487 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 213.92599487 89.72200012 Tm [(on)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 225.19400024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 229.69400024 89.72200012 Tm [(natu)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ral)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 10.80599976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 15.30599976 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 31.58300018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 36.08300018 105.3219986 Tm [(analog)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 65.45200348 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 69.95200348 105.3219986 Tm [(ce)-1(ra)1(mi)-1(d)1(e)-1(s)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 113.83999634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 118.33999634 105.3219986 Tm [(\(C6,)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 134.81100464 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 139.31100464 105.3219986 Tm [(C8,)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 152.77600098 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 157.27600098 105.3219986 Tm [(C16)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 173.852005 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 178.352005 105.3219986 Tm [(ce)-1(ra)1(mi)-1(d)1(e)-1(s)1(,)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 224.40699768 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 228.90699768 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 245.18400574 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(C8-dih)1(y)-1(d)1(roce)-1(ra)1(mi)-1(d)1(e)-1(\),)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 93.45800018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 97.95800018 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 107.03299713 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 111.53299713 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 116.50800323 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 121.00800323 120.92199707 Tm [(lesse)-1(r)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 145.38400269 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 149.88400269 120.92199707 Tm [(extent)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 176.91000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 181.41000366 120.92199707 Tm [(on)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 192.67799377 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 197.17799377 120.92199707 Tm [(C2-ce)-1(ra)1(mi)-1(d)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(e)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 5.10599995 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 9.60599995 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 25.88299942 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 30.38299942 136.52200317 Tm [(C6-dih)1(y)-1(d)1(roce)-1(ra)1(mi)-1(d)1(e)-1(,)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 120.83599854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 125.33599854 136.52200317 Tm [(but)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 139.98300171 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 144.48300171 136.52200317 Tm [(not)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 159.10400391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 163.60400391 136.52200317 Tm [(on)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 174.87199402 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 179.37199402 136.52200317 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 202.53100586 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 207.03100586 136.52200317 Tm [(lipids,)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 232.05299377 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 236.55299377 136.52200317 Tm [(su)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ch)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 10.05500031 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 14.55500031 152.12199402 Tm [(as)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 23.69599915 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 28.19599915 152.12199402 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 59.15999985 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 63.65999985 152.12199402 Tm [(sph)1(in)-1(g)1(osine)-1(s)1(.)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 122.08100128 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 126.58100128 152.12199402 Tm [(Bi)-1(nd)1(s)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 150.09199524 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 154.59199524 152.12199402 Tm [(ph)1(osph)1(oinositides.)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 235.94799805 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 165.5249939 -0.25 l 165.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 225 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 226 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 227 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 0.75 m 164.8999939 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 157.5 m 164.8999939 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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