%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 101.88600159 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 151.56199646 23.67700005 Tm 0 Tr [(CER1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 202.97399902 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 313.41400146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 57.75 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 81.375 12.82499981 Tm [(CER1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.74900055 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 158.24899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.49899292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CER1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.48200226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.85600281 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.5059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.88000488 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.43899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.81300354 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.60899353 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ce)1(rberus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.34999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.72399902 12.82499981 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.66600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.04000092 12.82499981 Tm [(DAN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.35299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.727005 12.82499981 Tm [(fami)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.92100525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.29499817 12.82499981 Tm [(BMP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.40800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.78199768 12.82499981 Tm [(antagon)-1(ist;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.71400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.08799744 12.82499981 Tm [(DAN)1(D)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.18301392 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CER1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.74900055 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 166.7749939 109.94999695 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.96899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.46899414 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.73300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.23300171 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.07499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.57499695 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.57600403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.07600403 11.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.02600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(kn)-1(o)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52099991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02099991 27.3220005 Tm [(superfa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.27200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.77200317 27.3220005 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.30499268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.80499268 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.31700134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.81700134 27.3220005 Tm [(nin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.41000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.91000366 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.48699951 27.3220005 Tm [(cy)-1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ein)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.31999969 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.81999969 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.09700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.59700012 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5719986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.0719986 42.92200089 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.02200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.52200317 42.92200089 Tm [(kn)-1(o)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.04299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.54299927 42.92200089 Tm [(region.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.67199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.17199707 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.97900391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.47900391 42.92200089 Tm [(ce)-1(rb)1(e)-1(rus-)1(re)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.56100464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cy)-1(t)1(oki)-1(nes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.63100052 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.13100052 58.52199936 Tm [(to)1(gether)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.5059967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.0059967 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.40200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.90200043 58.52199936 Tm [(Da)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.27799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.77799988 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.55499268 58.52199936 Tm [(DRM/G)1(re)-1(mlin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.09599304 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.59599304 58.52199936 Tm [(repres)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(en)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.00500011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50499916 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.47999954 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.97999954 74.12200165 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.18899918 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.68899918 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.53099823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.03099823 74.12200165 Tm [(bo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.65299988 74.12200165 Tm [(morp)1(hog)1(e)-1(netic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.03199768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.53199768 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.83900452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.33900452 74.12200165 Tm [(\(BMP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.29699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.79699707 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ta)1(gonist)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.43199921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.93199921 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.15399933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.65399933 89.72200012 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.68800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.18800354 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.63400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.13400269 89.72200012 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.85400391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.35400391 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.42900085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.92900085 89.72200012 Tm [(BMPs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.04200745 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.54200745 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.81900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.31900024 89.72200012 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.69299316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.19299316 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(heir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47900009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97900009 105.3219986 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.61700058 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.7749939 16.35000038 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.7749939 16.35000038 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CER1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.7749939 16.35000038 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(CER1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.46800232 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 166.7749939 16.35000038 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ce)-1(rb)1(e)-1(rus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.05899811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.55899811 11.72200012 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.00299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.50299835 11.72200012 Tm [(DA)1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.00800323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.50800323 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.58999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.08999634 11.72200012 Tm [(BMP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.03700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.53700256 11.72200012 Tm [(anta)1(gonist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.32400513 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 0.75 m 166.3999939 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 110.69999695 m 166.3999939 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 127.04999542 m 166.3999939 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 143.3999939 m 166.3999939 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 159.75 m 166.3999939 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.7250061 m 423.17498779 175.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>