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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.0739975 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 140.75 23.67700005 Tm 0 Tr [(CEP290)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.78599548 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 324.22601318 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CEP290)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 121.36499786 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.86500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.36500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CEP29)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84899902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.22299957 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.8730011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.24699402 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.80599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.17999268 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.97599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ce)1(n)-1(tr)1(o)-1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.36599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.34700012 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.72900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.71000671 12.82499981 Tm [(290;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.48500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.46600342 12.82499981 Tm [(CT)-1(8)1(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.63400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.61500549 12.82499981 Tm [(MKS4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.00300598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.98399353 12.82499981 Tm [(POC3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.08999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.0710144 12.82499981 Tm [(rd16;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.70098877 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.68200684 12.82499981 Tm [(BBS14;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.38198853 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.36300659 12.82499981 Tm [(JBTS)-1(5)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.49499512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 350.47601318 12.82499981 Tm [(LC)-1(A)1(10;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.01800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 382.99899292 12.82499981 Tm [(NP)1(HP6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29901123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(SL)-1(SN6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.97200012 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.34600067 30.49699783 Tm [(3H11A)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.8710022 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CEP290)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.11499786 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 151.2749939 -0.25 l 151.2749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.0249939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 151.0249939 156.75 l h f* Q q 1 0 0 1 150.6499939 0 cm -0.625 -0.25 m 272.7749939 -0.25 l 272.7749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.8730011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.3730011 11.72200012 Tm [(13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.92900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.42900085 11.72200012 Tm [(put)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.1289978 11.72200012 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.93600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(do)1(mains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.15999985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.65999985 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.63499832 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.13499832 27.3220005 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.09700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.59700012 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.99299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.49299622 27.3220005 Tm [(ho)1(mology)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.54800415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.04800415 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.1230011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.6230011 27.3220005 Tm [(SMC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.6309967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.1309967 27.3220005 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.92599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42599487 27.3220005 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(egregat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.15299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.65299988 42.92200089 Tm [(ATPa)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.23100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.73100281 42.92200089 Tm [(six)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.85399628 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.35399628 42.92200089 Tm [(KID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.56800079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.06799316 42.92200089 Tm [(mot)1(ifs,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.42300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.92300415 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.46699524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.96699524 42.92200089 Tm [(tr)1(opomyos)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.9730072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.4730072 42.92200089 Tm [(ho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(molog)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.79199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.29199982 58.52199936 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.28500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.78500366 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.06199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.56199646 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.08300018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.58300018 58.52199936 Tm [(ATP/GTP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.78500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.28500366 58.52199936 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.42900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.92900085 58.52199936 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.94999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.44999695 58.52199936 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.4730072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.9730072 58.52199936 Tm [(A.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.97200012 58.52199936 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.45500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.95500183 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.51599884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.01599884 74.12200165 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.6989975 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.1989975 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.27400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77400208 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.7749939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.2749939 74.12200165 Tm [(ce)-1(ntr)1(osome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.3789978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.8789978 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.15600586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.65600586 74.12200165 Tm [(ci)-1(lia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.32899475 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.82899475 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.10600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.60600281 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 89.72200012 Tm [(sites)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.82799911 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.32799911 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.60599899 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.10599899 89.72200012 Tm [(N-g)1(ly)-1(cosylat)1(i)-1(o)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.94799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.44799805 89.72200012 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.93600464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.43600464 89.72200012 Tm [(sulfat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.82000732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.32000732 89.72200012 Tm [(ph)1(osph)1(oryl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(at)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.15699959 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.65699959 105.3219986 Tm [(N-myrist)1(oylation,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.45200348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.95200348 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.22899628 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.72900391 105.3219986 Tm [(amida)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.44500732 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.94500732 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.79400635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.29400635 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.23500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.73500061 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.19099426 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.36299896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.86299896 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.37000275 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.87000275 120.92199707 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99700165 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49700165 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.89300537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.39300537 120.92199707 Tm [(Joubert)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8690033 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.3690033 120.92199707 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.29899597 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.79899597 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.07600403 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.57600403 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ephro)1(n)-1(o)1(pht)1(hisis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.12799835 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.62799835 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.90499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.40499878 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.40599823 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.90599823 136.52200317 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.63499451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.13499451 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.977005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.477005 136.52200317 Tm [(antib)1(odies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.63999939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.13999939 136.52200317 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.30599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.80599976 136.52200317 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10299969 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60300064 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.90999985 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.40999985 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.97100067 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.47100067 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.59799957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.09799957 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.4940033 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.9940033 152.12199402 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.90299988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.40299988 152.12199402 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.27999878 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.77999878 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.62199402 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.12199402 152.12199402 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.37800598 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 0.75 m 150.6499939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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