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10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 61.9640007 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -25 61.9640007 Tm [<00030004>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -1.375 61.9640007 Tm [(EE)-1(A)1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 22.90100098 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 75.40100098 61.9640007 Tm [(  )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 85.90100098 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EEA1)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 105.38500214 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 107.75900269 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 133.40899658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 135.78300476 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 179.34199524 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 181.71600342 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 219.51199341 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ear)1(l)-1(y)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 84.07700348 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 86.4509964 12.82499981 Tm [(endo)-1(some)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 131.5019989 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 133.87600708 12.82499981 Tm [(anti)-1(ge)1(n)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 166.03199768 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 168.40600586 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 176.53700256 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 178.91099548 12.82499981 Tm [(MST)-1(10)1(5;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 216.60400391 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 218.97799683 12.82499981 Tm [(ZF)-1(YVE)-1(2;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 253.05200195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 255.42599487 12.82499981 Tm [(MST)-1(P)1(105)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 295.73400879 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0014000D>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(EE)-1(A)1(1)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 84.65100098 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 87 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 90 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 155.5249939 0.75 l 155.5249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 156.5249939 -0.25 l 156.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 156.2749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 156.2749939 156.75 l h f* Q q 1 0 0 1 155.8999939 0 cm -0.625 -0.25 m 267.5249939 -0.25 l 267.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(EEA)1(1)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 21.50699997 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 26.00699997 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 32.56800079 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 37.06800079 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 47.5890007 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 52.0890007 11.72200012 Tm [(early)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 72.76499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 77.26499939 11.72200012 Tm [(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 125.08599854 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 129.58599854 11.72200012 Tm [(marker)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 159.8730011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 164.3730011 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 180.6499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 185.1499939 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 190.125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 194.625 11.72200012 Tm [(Rab)1(5)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 216.50100708 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 221.00100708 11.72200012 Tm [(effec)-1(t)1(or)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 254.47900391 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 31.30699921 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 35.80699921 27.3220005 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 73.01499939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 77.51499939 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 89.79299927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 94.29299927 27.3220005 Tm [(early)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 114.96900177 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 119.46900177 27.3220005 Tm [(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 167.28999329 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 171.78999329 27.3220005 Tm [(membrane)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 218.57400513 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 223.07400513 27.3220005 Tm [(fusion)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 249.56900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 254.06900024 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nd)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 11.30300045 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 15.80300045 42.92200089 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)1(.)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 61.47999954 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 65.98000336 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 81.78700256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 86.28700256 42.92200089 Tm [(carbo)1(xy)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 120.0059967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 124.5059967 42.92200089 Tm [(terminus)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 162.48800659 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 166.98800659 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 175.83000183 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 180.33000183 42.92200089 Tm [(EEA)1(1)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 201.83700562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 206.33700562 42.92200089 Tm [(contains)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 242.55200195 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 247.05200195 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 252.0269928 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(FYVE)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 21.24799919 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 25.74799919 58.52199936 Tm [(do)1(main)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 58.57500076 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 63.07500076 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 88.17199707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 92.67199707 58.52199936 Tm [(binds)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 116.28399658 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 120.78399658 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 129.85899353 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 134.35899353 58.52199936 Tm [(ph)1(osph)1(atid)1(y)-1(linosito)1(l-3-ph)1(os)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ph)1(ate)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 24.72400093 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 29.22400093 74.12200165 Tm [(\(Pt)1(dIns\(3\)P\),)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 81.17199707 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 85.67199707 74.12200165 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 125.34999847 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 129.8500061 74.12200165 Tm [(EEA)1(1)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 151.35699463 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 155.85699463 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 164.93200684 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 169.43200684 74.12200165 Tm [(early)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 190.10800171 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 194.60800171 74.12200165 Tm [(en)-1(d)1(osomes.)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 246.49899292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 250.99899292 74.12200165 Tm [(T)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(he)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 10.64799976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 15.14799976 89.72200012 Tm [(st)1(able)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 40.89099884 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 45.39099884 89.72200012 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 93.31800079 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 97.81800079 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 106.66000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 111.16000366 89.72200012 Tm [(EEA)1(1)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 132.66700745 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 137.16700745 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 155.56300354 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 160.06300354 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 174.06399536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 178.56399536 89.72200012 Tm [(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 226.38499451 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 230.88499451 89.72200012 Tm [(memb)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(rane)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 19.06299973 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 23.56299973 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 30.12400055 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 34.62400055 105.3219986 Tm [(regulat)1(e)-1(d)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 76.05599976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 80.55599976 105.3219986 Tm [(by)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 91.06800079 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 95.56800079 105.3219986 Tm [(PI3)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 108.9980011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 113.4980011 105.3219986 Tm [(ki)-1(na)1(se)-1(,)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 142.7519989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 147.2519989 105.3219986 Tm [(Rab)1(5)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 169.12800598 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 173.62800598 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 189.90499878 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 194.40499878 105.3219986 Tm [(calc)-1(ium/c)-1(almo)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(dulin.)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 23.80500031 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 28.30500031 120.92199707 Tm [(Onc)-1(e)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 50.80500031 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 55.30500031 120.92199707 Tm [(on)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 66.57299805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 71.07299805 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 85.0739975 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 89.5739975 120.92199707 Tm [(membrane,)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 138.5249939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 143.0249939 120.92199707 Tm [(EEA)1(1)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 164.53199768 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 169.03199768 120.92199707 Tm [(interacts)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 205.87600708 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 210.37600708 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 228.77200317 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 233.27200317 120.92199707 Tm [(Rab)1(5)-1(,)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 257.31399536 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(NSF)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 17.29199982 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 21.79199982 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 38.06900024 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 42.56900024 136.52200317 Tm [(syntaxin)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 77.875 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 82.375 136.52200317 Tm [(13)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 92.93099976 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 97.43099976 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 106.5059967 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 111.0059967 136.52200317 Tm [(pro)1(mote)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 148.5269928 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 153.0269928 136.52200317 Tm [(early)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 173.70300293 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 178.20300293 136.52200317 Tm [(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 226.02400208 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 230.52400208 136.52200317 Tm [(memb)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(rane)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 19.06299973 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 23.56299973 152.12199402 Tm [(do)1(c)-1(kin)-1(g)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 58.15200043 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 62.65200043 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 78.92900085 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 83.42900085 152.12199402 Tm [(fusion.)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 112.08999634 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 155.5249939 0.75 l 155.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.5249939 -0.25 l 156.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 249 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 250 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 156.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 156.2749939 16.35000038 l h f* Q q 1 0 0 1 155.8999939 0 cm -0.625 -0.25 m 267.5249939 -0.25 l 267.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 251 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.8999939 0.75 m 155.8999939 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.8999939 157.5 m 155.8999939 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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