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1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -57.5 61.9640007 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -52.25 61.9640007 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -28.625 61.9640007 Tm [(ED)-1(N)1(3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -2.31300354 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 50.18699646 61.9640007 Tm [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 55.43699646 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <</Lang (zh-CN) /MCID 13 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 14 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EDN3)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 107.41999817 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 109.79399872 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 135.44400024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 137.81799316 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 181.3769989 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 183.75100708 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 221.54699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ET)-1(3)1(;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 81.375 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 83.74900055 12.82499981 Tm [(ET)-1(-3;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 105.33899689 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 107.71299744 12.82499981 Tm [(WS4B;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 135.72200012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 138.09599304 12.82499981 Tm [(HS)-1(CR4;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 168.89399719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 171.26800537 12.82499981 Tm [(PP)1(ET)-1(3)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 197.68200684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ED)-1(N)1(3)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 86.68699646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 89.06099701 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 83 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 156.2749939 0.75 l 156.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 157.2749939 -0.25 l 157.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 157.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 157.0249939 172.3500061 l h f* Q q 1 0 0 1 156.6499939 0 cm -0.625 -0.25 m 266.7749939 -0.25 l 266.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(e)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ndot)1(helin)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 41.36100006 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 45.86100006 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 74.10900116 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 78.60900116 27.3220005 Tm [(Endo)1(thelin)-1(s)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 129.08500671 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 133.58500671 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 147.10299683 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 151.60299683 27.3220005 Tm [(en)-1(d)1(oth)1(e)-1(lium-d)1(e)-1(rived)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 242.67999268 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 247.17999268 27.3220005 Tm [(va)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(soa)1(c)-1(t)1(i)-1(v)1(e)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 34.95399857 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 39.45399857 42.92200089 Tm [(pept)1(ides)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 76.83399963 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 81.33399963 42.92200089 Tm [(involved)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 117.70300293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 122.20300293 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 130.14399719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 134.64399719 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 139.6190033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 144.1190033 42.92200089 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 172.87199402 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 177.37199402 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 186.21400452 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 190.71400452 42.92200089 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 232.72999573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 237.22999573 42.92200089 Tm [(func)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tio)1(n)-1(s.)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 23.34799957 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 27.84799957 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 43.65499878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 48.15499878 58.52199936 Tm [(active)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 73.22100067 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 77.72100067 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 98.43199921 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 102.93199921 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 111.77400208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 116.27400208 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 131.72999573 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 136.22999573 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 167.53700256 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 172.03700256 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 178.5980072 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 183.0980072 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 188.07299805 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 192.57299805 58.52199936 Tm [(21)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 203.1289978 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 207.6289978 58.52199936 Tm [(amino)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 234.69900513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 239.19900513 58.52199936 Tm [(acid)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 256.83898926 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 33.2140007 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 37.7140007 74.12200165 Tm [(pro)1(c)-1(essed)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 81.43499756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 85.93499756 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 106.64600372 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 111.14600372 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 125.14700317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 129.64700317 74.12200165 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 170.75799561 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 175.25799561 74.12200165 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 208.73100281 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 213.23100281 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 229.03799438 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 233.53799438 74.12200165 Tm [(active)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 258.60400391 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 33.2140007 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 37.7140007 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 44.27500153 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 48.77500153 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 53.75 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 58.25 89.72200012 Tm [(ligand)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 85.0739975 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 89.5739975 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 101.85199738 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 106.35199738 89.72200012 Tm [(en)-1(d)1(oth)1(e)-1(lin)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 152.82000732 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 157.32000732 89.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 193.74200439 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 198.24200439 89.72200012 Tm [(type)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 217.21299744 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 221.71299744 89.72200012 Tm [(B)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 227.36000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 231.86000061 89.72200012 Tm [(\(EDN)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(RB\).)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 16.69499969 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 21.19499969 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 37.0019989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 41.5019989 105.3219986 Tm [(interaction)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 87.84200287 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 92.34200287 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 101.18399811 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 105.68399811 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 121.13999939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 125.63999939 105.3219986 Tm [(en)-1(d)1(oth)1(e)-1(lin)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 172.10800171 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 176.60800171 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 195.0039978 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 199.5039978 105.3219986 Tm [(EDNR)1(B)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 230.14700317 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 234.64700317 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 241.20799255 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 245.70799255 105.3219986 Tm [(es)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(sential)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 27.93600082 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 32.43600082 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 44.7140007 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 49.2140007 120.92199707 Tm [(development)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 106.21099854 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 110.71099854 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 119.5530014 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 124.0530014 120.92199707 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 151.05700684 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 155.55700684 120.92199707 Tm [(cre)-1(st)1(-d)1(e)-1(rived)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 212.30799866 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 216.80799866 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 231.21800232 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 235.71800232 120.92199707 Tm [(line)-1(a)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ges,)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 17.19599915 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 21.69599915 136.52200317 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 41.46300125 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 45.96300125 136.52200317 Tm [(as)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 55.10400009 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 59.60400009 136.52200317 Tm [(mel)-1(a)1(noc)-1(ytes)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 113.68299866 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 118.18299866 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 134.46000671 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 138.96000671 136.52200317 Tm [(en)-1(t)1(e)-1(r)1(ic)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 168.41700745 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 172.91700745 136.52200317 Tm [(ne)-1(uro)1(n)-1(s)1(.)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 210.1519928 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 214.6519928 136.52200317 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 258.50100708 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 7.94099998 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 12.44099998 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 27.89699936 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 32.39699936 152.12199402 Tm [(gene)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 53.9129982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 58.4129982 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 74.69000244 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 79.19000244 152.12199402 Tm [(EDNR)1(B)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 109.83300018 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 114.33300018 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 134.67999268 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 139.17999268 152.12199402 Tm [(been)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 160.68699646 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 165.18699646 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 210.31399536 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 214.81399536 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 233.21000671 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 237.71000671 152.12199402 Tm [(Hi)-1(r)1(s)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(chsprung)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 40.25400162 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 44.75400162 167.72200012 Tm [(disease)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 76.42500305 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 80.92500305 167.72200012 Tm [(\(HS)-1(CR)1(\))] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 110.98799896 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 115.48799896 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 131.76499939 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 136.26499939 167.72200012 Tm [(Wa)1(ardenburg)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 195.70500183 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 200.20500183 167.72200012 Tm [(syndrome)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 243.13499451 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 247.63499451 167.72200012 Tm [(\()] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.6499939 0.75 m 156.6499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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