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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.91899872 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.59500122 23.67700005 Tm 0 Tr [(CD)-1(K1)1(8)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.94000244 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.38000488 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDK18)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.90699768 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.40699768 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 169.90699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK1)1(8)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 111.89099884 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 114.26499939 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 185.8480072 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 188.22200012 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 226.01800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cy)1(cl)-1(in)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 86.96900177 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 89.34300232 12.82499981 Tm [(depend)-1(e)1(n)-1(t)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 136.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 138.49000549 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 165.55000305 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 167.92399597 12.82499981 Tm [(18;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 181.3769989 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 183.75100708 12.82499981 Tm [(PCTK3)1(;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 213.477005 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 215.85099792 12.82499981 Tm [(PCTAIRE;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 254.34899902 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 256.72299194 12.82499981 Tm [(PCTAIRE3)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 297.73300171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK18)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 91.15699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 83 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 175.0249939 31.95000076 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(May)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 18.53199959 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 23.03199959 11.72200012 Tm [(play)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 40.9129982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 45.4129982 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 50.38800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 54.88800049 11.72200012 Tm [(role)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 71.54799652 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 76.04799652 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 83.98899841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 88.48899841 11.72200012 Tm [(signal)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 113.72200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 118.22200012 11.72200012 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 172.52999878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 177.02999878 11.72200012 Tm [(casc)-1(a)1(des)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 215.20100403 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 219.70100403 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 227.64199829 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 232.14199829 11.72200012 Tm [(te)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(rminally)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 34.3390007 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 38.8390007 27.3220005 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(ted)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 97.36499786 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 101.86499786 27.3220005 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 122.60700226 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 114 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 115 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 116 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 120 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 125 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 126 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDK)1(1)-1(8)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 29.14500046 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 128 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 129 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 130 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(CDK)1(1)-1(8)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 145.49099731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 140 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 143 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 144 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(clin)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 24.12599945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 28.62599945 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 75.65200043 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 80.15200043 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 107.23999786 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 111.73999786 11.72200012 Tm [(18)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 122.29599762 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 152 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 153 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 154 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PCTK3;)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 29.84300041 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 34.3429985 11.72200012 Tm [(PCTAIR)1(E;)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 72.99700165 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 77.49700165 11.72200012 Tm [(PCTAIR)1(E3)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 119.26300049 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 160 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <</MCID 161 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 162 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q07)-1(00)-1(2)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 164 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 25.2689991 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 29.7689991 11.72200012 Tm [(Recommend)1(e)-1(d)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 97.8010025 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 102.3010025 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <</MCID 169 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 140.14700317 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 170 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(50)-1(00)-1(-)1(1)-1(00)-1(00)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 51.39400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 146.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 172 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <</MCID 179 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 180 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(54)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 162.75 cm q /GS2 gs 1 g 0.375 0.75 m 174.2749939 0.75 l 174.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 175.2749939 -0.25 l 175.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 184 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Positive)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 56.09600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 60.59600067 11.72200012 Tm [(control:)] TJ ET EMC /P <</MCID 189 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.0249939 16.35000038 l h f* Q q 1 0 0 1 174.6499939 0 cm -0.625 -0.25 m 248.7749939 -0.25 l 248.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 190 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HL)-1(-)1(6)-1(0)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 26.02899933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 30.52899933 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 44.93899918 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 49.43899918 11.72200012 Tm [(lysate)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 74.19799805 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 179.10002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 0.75 m 174.6499939 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 32.70000076 m 174.6499939 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 49.05000305 m 174.6499939 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 65.40000153 m 174.6499939 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 81.75 m 174.6499939 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 98.09999847 m 174.6499939 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 114.44999695 m 174.6499939 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 130.80000305 m 174.6499939 146.40000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 147.15000916 m 174.6499939 162.75001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.6499939 163.50001526 m 174.6499939 179.10002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 179.10002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 422.42498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 422.42498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 422.42498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 422.42498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 422.42498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 422.42498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 422.42498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 146.77500916 m 422.42498779 146.77500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 163.12501526 m 422.42498779 163.12501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 179.47502136 m 423.17498779 179.47502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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