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g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CDK14)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.40699768 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.90699768 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 180.40699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK1)1(4)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 111.89099884 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 114.26499939 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 185.8480072 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 188.22200012 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 226.01800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PFTK1;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 91.95200348 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 94.3259964 12.82499981 Tm [(PFTAIRE1)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 134.56199646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK14)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 91.15699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 76 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 157.7749939 0.75 l 157.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 158.7749939 -0.25 l 158.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 158.5249939 172.3500061 l h f* Q q 1 0 0 1 158.1499939 0 cm -0.625 -0.25 m 265.2749939 -0.25 l 265.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Se)-1(r)1(in)-1(e/thr)1(e)-1(onine-pro)1(tein)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 107.58300018 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 112.08300018 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 139.17100525 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 143.67100525 11.72200012 Tm [(involved)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 180.03999329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 184.53999329 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 192.48100281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 196.98100281 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 210.98199463 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 215.48199463 11.72200012 Tm [(control)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 246.16900635 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 250.66900635 11.72200012 Tm [(o)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 21.62100029 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 26.12100029 27.3220005 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 70.83100128 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 75.33100128 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 89.74099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 94.24099731 27.3220005 Tm [(cy)-1(cle)-1(,)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 117.6989975 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 122.1989975 27.3220005 Tm [(wh)1(ose)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 149.84100342 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 154.34100342 27.3220005 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 184.81300354 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 189.31300354 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 195.87399292 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 200.37399292 27.3220005 Tm [(controlled)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 244.31900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 248.81900024 27.3220005 Tm [(b)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(y)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 4.76399994 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 9.26399994 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 19.78499985 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 24.28499985 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 69.41200256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 73.91200256 42.92200089 Tm [(cy)-1(clin)-1(.)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 100.20400238 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 104.70400238 42.92200089 Tm [(Acts)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 123.06900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 127.56900024 42.92200089 Tm [(as)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 136.71000671 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 141.21000671 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 146.18499756 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 150.68499756 42.92200089 Tm [(ce)-1(ll-cyc)-1(le)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 190.27999878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 194.77999878 42.92200089 Tm [(regulat)1(or)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 234.50700378 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 239.00700378 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 247.84899902 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Wnt)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 18.05699921 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 22.55699921 58.52199936 Tm [(signaling)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 61.48799896 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 65.98799896 58.52199936 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 102.4489975 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 106.9489975 58.52199936 Tm [(during)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 135.38600159 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 139.88600159 58.52199936 Tm [(G2/M)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 164.49499512 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 168.99499512 58.52199936 Tm [(ph)1(ase)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 194.53199768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 199.03199768 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 209.54400635 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 214.04400635 58.52199936 Tm [(mediat)1(i)-1(n)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(g)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 24.25799942 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 28.75799942 74.12200165 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 99.53199768 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 104.03199768 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 112.87400055 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 117.37400055 74.12200165 Tm [(LRP6)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 138.6519928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 143.1519928 74.12200165 Tm [(at)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 151.47999573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 155.97999573 74.12200165 Tm [('Se)-1(r-)1(1)-1(49)-1(0',)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 201.50300598 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 206.00300598 74.12200165 Tm [(leading)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 237.93400574 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 242.43400574 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 251.50900269 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 14.0010004 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 18.50099945 89.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 60.45100021 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 64.9509964 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 73.79299927 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 78.29299927 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 92.29399872 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 96.79399872 89.72200012 Tm [(Wnt)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 114.85099792 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 119.35099792 89.72200012 Tm [(signaling)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 158.28199768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 162.78199768 89.72200012 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 201.41000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 205.91000366 89.72200012 Tm [(Acts)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 224.2749939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 228.7749939 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 237.91600037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 242.41600037 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 247.39100647 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 251.89100647 89.72200012 Tm [(r)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(egulato)1(r)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 36.29000092 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 40.79000092 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 49.63199997 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 54.13199997 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 68.54199982 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 73.04199982 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 94.33399963 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 98.83399963 105.3219986 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 150.03500366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 154.53500366 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 170.81199646 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 175.31199646 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 189.72200012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 194.22200012 105.3219986 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 247.57200623 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 252.07200623 105.3219986 Tm [(v)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ia)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 7.36999989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 11.86999989 120.92199707 Tm [(its)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 21.7840004 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 26.2840004 120.92199707 Tm [(interaction)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 72.62400055 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 77.12400055 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 95.51999664 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 100.01999664 120.92199707 Tm [(CCDN3.)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 133.67799377 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 138.17799377 120.92199707 Tm [(Pho)1(spho)1(ryl)-1(a)1(tes)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 204.32000732 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 208.82000732 120.92199707 Tm [(RB1)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 225.61999512 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 230.11999512 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 238.06100464 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 242.56100464 120.92199707 Tm [(vitr)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(o,)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 7.88800001 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 12.38799953 136.52200317 Tm [(ho)1(weve)-1(r)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 49.13100052 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 53.63100052 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 67.63200378 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 72.13200378 136.52200317 Tm [(rele)-1(va)1(n)-1(ce)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 113.04100037 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 117.54100037 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 126.38300323 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 130.88299561 136.52200317 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 150.6499939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 155.1499939 136.52200317 Tm [(result)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 179.15299988 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 183.65299988 136.52200317 Tm [(remains)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 217.71099854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 222.21099854 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 231.28599548 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 235.78599548 136.52200317 Tm [(be)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 246.63999939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 251.13999939 136.52200317 Tm [(c)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(onfirmed)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 39.51599884 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 44.01599884 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 51.95700073 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 56.45700073 152.12199402 Tm [(vivo.)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 76.18800354 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 80.68800354 152.12199402 Tm [(May)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 99.22000122 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 103.72000122 152.12199402 Tm [(also)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 120.97699738 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 125.47699738 152.12199402 Tm [(play)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 143.35800171 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 147.85800171 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 152.83299255 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 157.33299255 152.12199402 Tm [(role)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 173.99299622 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 178.49299622 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 186.43400574 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 190.93400574 152.12199402 Tm [(mei)-1(o)1(sis,)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 225.48399353 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 229.98399353 152.12199402 Tm [(ne)-1(uro)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(n)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 5.546 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 10.04599953 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 71.37200165 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 75.87200165 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 92.14900208 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 96.64900208 167.72200012 Tm [(may)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 114.81999969 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 119.31999969 167.72200012 Tm [(indirec)-1(t)1(ly)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 158.98100281 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 163.48100281 167.72200012 Tm [(act)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 176.32200623 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 180.82200623 167.72200012 Tm [(as)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 189.96299744 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 194.46299744 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 199.43800354 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 203.93800354 167.72200012 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 240.8999939 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 245.3999939 167.72200012 Tm [(re)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.1499939 0.75 m 158.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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