%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 129 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(CD)-1(K1)1(1B)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 127.35299683 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 237.79299927 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -35.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -11.875 61.9640007 Tm [(CDK11B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 24.6190033 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 77.1190033 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.3690033 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK1)1(1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.60199738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97599792 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.62600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.55900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.93299866 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.72900391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(p58;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.97000122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.70600128 12.82499981 Tm [(PK)1(58;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.77500153 12.82499981 Tm [(CDK11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.74200439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.47799683 12.82499981 Tm [(CL)-1(K)1(-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.29200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.02799988 12.82499981 Tm [(CDC)-1(2)1(L)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.55299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.28900146 12.82499981 Tm [(PITSL)-1(REA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.42700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.16299438 12.82499981 Tm [(p58CL)-1(K)1(-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.13699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.87298584 12.82499981 Tm [(CDK11-p46;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 361.21499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.95098877 12.82499981 Tm [(CDK11-p58;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(p58CDC)-1(2L1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.68500137 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.05899811 30.49699783 Tm [(CDK11-p110)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.91300201 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 167.69500732 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 201.23399353 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 234.772995 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK11B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.8690033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 268.31201172 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 301.85101318 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 335.39001465 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 368.9289856 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 402.46798706 m 416.75 402.46798706 l 416.75 433.66799927 l -1.45000005 433.66799927 l h f* Q q 1 0 0 1 0 402.46798706 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 433.66799927 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 461.60699463 cm q 1 g 0.375 0.75 m 178.0249939 0.75 l 178.0249939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 179.0249939 -0.25 l 179.0249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 178.7749939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 178.7749939 141.1499939 l h f* Q q 1 0 0 1 178.3999939 0 cm -0.625 -0.25 m 245.0249939 -0.25 l 245.0249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.9129982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.4129982 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.50099945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.00099945 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.24900055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.74900055 27.3220005 Tm [(Members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.53900146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.03900146 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.8809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.3809967 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.83700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.33700562 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.42500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.92500305 27.3220005 Tm [(fa)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.5539999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0539999 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.5720005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.0719986 42.92200089 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.89099884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.39099884 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.46600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.96600342 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.81999969 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.31999969 42.92200089 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.52799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.02799988 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.30599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.80599976 42.92200089 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.51600647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.01600647 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.42599487 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.92599487 42.92200089 Tm [(cy)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.50099993 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.0010004 58.52199936 Tm [(control.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.85499954 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.35499954 58.52199936 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.86299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.36299896 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.43800354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.93800354 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.91300201 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.41300201 58.52199936 Tm [(segmen)-1(t)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.25 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.75 58.52199936 Tm [(duplicatio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.26100159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.76100159 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.21699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.71699524 58.52199936 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(sha)1(re)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.99700165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.49700165 74.12200165 Tm [(very)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.52799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.02799988 74.12200165 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.76300049 74.12200165 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.61000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.11000061 74.12200165 Tm [(identity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.77900696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.27900696 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.67500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.17500305 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.6499939 74.12200165 Tm [(ne)-1(ig)1(hb)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(oring)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.8560009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.3560009 89.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.0379982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.5379982 89.72200012 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.61799622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.11799622 89.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.2990036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.7990036 89.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.48100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.98100281 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.49899292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.99899292 89.72200012 Tm [(frequently)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.6289978 89.72200012 Tm [(dele)-1(t)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.21000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 105.3219986 Tm [(alt)1(e)-1(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.78699875 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.28699875 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.22800064 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.72800064 105.3219986 Tm [(ne)-1(uro)1(blast)1(oma.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.01699829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.51699829 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.32400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.82400513 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.1309967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.6309967 105.3219986 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.71899414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.21899414 105.3219986 Tm [(en)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(od)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.34199905 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.84199905 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.35400009 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.85400009 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.31000137 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.81000137 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.3259964 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.8259964 120.92199707 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.86000061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.36000061 120.92199707 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.21399689 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.71399689 120.92199707 Tm [(cl)-1(eaved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.29100037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.79100037 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.30299377 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.80299377 120.92199707 Tm [(caspa)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.61799622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.11799622 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.39500427 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 136.52200317 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.55199814 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.05199814 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.02700043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.52700043 136.52200317 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.18699646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.68699646 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.62799835 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.12799835 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.53800201 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.03800201 136.52200317 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.19900513 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q 1 g 0.375 0.75 m 178.0249939 0.75 l 178.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 179.0249939 -0.25 l 179.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 178.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 178.7749939 16.35000038 l h f* Q q 1 0 0 1 178.3999939 0 cm -0.625 -0.25 m 245.0249939 -0.25 l 245.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 157.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 178.3999939 0.75 m 178.3999939 141.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 178.3999939 141.8999939 m 178.3999939 157.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 157.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.875 m 423.17498779 157.875 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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