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12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CDK11A)1(/C)-1(DK)1(11B)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 161.40699768 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 213.90699768 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 219.15699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK1)1(1A/CD)-1(K)1(11B)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 155.88999939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 158.26400757 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 183.91400146 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 186.28799438 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 229.84700012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 232.22099304 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 270.01699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(2)1(L)-1(2;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 98.52500153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 102.5039978 12.82499981 Tm [(CDC)-1(2)1(L)-1(3;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 138.02900696 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 142.00799561 12.82499981 Tm [(p58GTA;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 178.79400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 182.772995 12.82499981 Tm [(PITSL)-1(RE;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 218.83599854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 222.81500244 12.82499981 Tm [(CDK11-p46;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 273.15701294 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 277.13598633 12.82499981 Tm [(CDK11-p58;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 327.47799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 331.45700073 12.82499981 Tm [(CDK11-p110)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 384.31100464 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 388.29000854 12.82499981 Tm [(/)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 392.34500122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 396.32400513 12.82499981 Tm [(p58;)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 415.29400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(PK)1(58;)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 24.33300018 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 26.70700073 30.49699783 Tm [(CDK11;)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 57.67399979 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 60.04800034 30.49699783 Tm [(CL)-1(K)1(-1;)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 86.86199951 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 89.23600006 30.49699783 Tm [(CDC)-1(2)1(L)-1(1;)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 124.76100159 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 127.13500214 30.49699783 Tm [(p58CL)-1(K)1(-1;)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 170.10899353 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 172.48300171 30.49699783 Tm [(CDK11-p46;)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 222.82499695 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 225.19900513 30.49699783 Tm [(CDK11-p58;)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 275.54098511 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK11A)1(/C)-1(DK)1(11B)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 135.15699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <</Lang (zh-CN) /MCID 89 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 91 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 93 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <</Lang (zh-CN) /MCID 98 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <</MCID 104 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 105 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <</MCID 107 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 180.2749939 0.75 l 180.2749939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 181.2749939 -0.25 l 181.2749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 109 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.0249939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 181.0249939 156.75 l h f* Q q 1 0 0 1 180.6499939 0 cm -0.625 -0.25 m 242.7749939 -0.25 l 242.7749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cyc)-1(lin-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 76.5530014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 81.0530014 11.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 112.30699921 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 116.80699921 11.72200012 Tm [(\(CDK)1(s\))] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 145.57400513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 150.07400513 11.72200012 Tm [(are)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 163.59199524 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 168.09199524 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 173.06700134 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 177.56700134 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 203.64900208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 208.14900208 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 216.99099731 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 221.49099731 11.72200012 Tm [(pr)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 22.12199974 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 26.62199974 27.3220005 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 57.87599945 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 62.37599945 27.3220005 Tm [(first)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 78.84700012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 83.34700012 27.3220005 Tm [(discovered)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 130.02999878 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 134.52999878 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 146.80799866 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 151.30799866 27.3220005 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 171.14100647 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 175.64100647 27.3220005 Tm [(role)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 192.30099487 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 196.80099487 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 204.74200439 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 209.24200439 27.3220005 Tm [(regul)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(in)-1(g)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 22.02499962 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 26.52499962 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 40.52600098 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 45.02600098 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 59.43600082 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 63.93600082 42.92200089 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 87.39399719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 91.89399719 42.92200089 Tm [(They)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 112.46499634 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 116.96499634 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 130.48300171 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 134.98300171 42.92200089 Tm [(also)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 152.24000549 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 156.74000549 42.92200089 Tm [(involved)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 193.10899353 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 197.60899353 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 205.55000305 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 210.05000305 42.92200089 Tm [(regul)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(in)-1(g)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 22.02499962 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 26.52499962 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion,)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 83.27600098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 87.77600098 58.52199936 Tm [(mRNA)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 115.73400116 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 120.23400116 58.52199936 Tm [(pro)1(c)-1(essing,)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 168.95599365 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 173.45599365 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 189.73300171 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 194.23300171 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 208.23399353 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 212.73399353 58.52199936 Tm [(dif)1(fe)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rentiat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 41.82699966 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 46.32699966 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 55.16899872 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 59.66899872 74.12200165 Tm [(ne)-1(r)1(ve)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 83.58799744 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 88.08799744 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 108.83000183 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 113.33000183 74.12200165 Tm [(They)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 133.90100098 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 138.40100098 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 151.91900635 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 156.41900635 74.12200165 Tm [(present)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 188.8809967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 193.3809967 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 201.32200623 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 205.82200623 74.12200165 Tm [(all)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 215.58700562 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 220.08700562 74.12200165 Tm [(kn)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ow)1(n)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 18.37400055 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 22.87400055 89.72200012 Tm [(eu)-1(karyot)1(e)-1(s)1(,)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 72.11499786 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 76.61499786 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 92.89199829 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 97.39199829 89.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 117.22499847 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 121.72499847 89.72200012 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 166.21499634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 170.71499634 89.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 206.45599365 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 210.95599365 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 218.89700317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 223.39700317 89.72200012 Tm [(th)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 24.01600075 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 28.51600075 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 49.80799866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 54.30799866 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 68.98999786 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 73.48999786 105.3219986 Tm [(been)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 94.99700165 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 99.49700165 105.3219986 Tm [(evolutionarily)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 157.97099304 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 162.47099304 105.3219986 Tm [(conse)-1(rv)1(e)-1(d)1(.)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 208.71499634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 213.21499634 105.3219986 Tm [(CDK)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(s)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 4.16599989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 8.66600037 120.92199707 Tm [(are)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 22.18400002 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 26.68400002 120.92199707 Tm [(relatively)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 65.33399963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 69.83399963 120.92199707 Tm [(small)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 92.19799805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 96.69799805 120.92199707 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 134.33700562 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 138.83700562 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 157.23300171 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 161.73300171 120.92199707 Tm [(molec)-1(ular)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 204.2539978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 208.7539978 120.92199707 Tm [(weig)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ht)1(s)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 13.06099987 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 17.56100082 136.52200317 Tm [(rang)1(i)-1(ng)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 50.97299957 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 55.47299957 136.52200317 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 76.18399811 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 80.68399811 136.52200317 Tm [(34)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 91.23999786 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 95.73999786 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 104.81500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 109.31500244 136.52200317 Tm [(40)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 119.8710022 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 124.3710022 136.52200317 Tm [(kDa,)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 143.26699829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 147.76699829 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 164.04400635 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 168.54400635 136.52200317 Tm [(contain)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 200.59300232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 205.09300232 136.52200317 Tm [(litt)1(le)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 224.09100342 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(more)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 22.69799995 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 27.19799995 152.12199402 Tm [(th)1(an)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 46.61299896 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 51.11299896 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 65.11399841 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 69.61399841 152.12199402 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 96.70200348 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 101.20200348 152.12199402 Tm [(do)1(main.)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 136.19599915 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 140.69599915 152.12199402 Tm [(By)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 151.10699463 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 155.60699463 152.12199402 Tm [(definition,)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 199.10800171 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 203.60800171 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 208.58299255 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 213.08299255 152.12199402 Tm [(CDK)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 231.67199707 152.12199402 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.6499939 0.75 m 180.6499939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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