%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 135 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.91899872 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.59500122 23.67700005 Tm 0 Tr [(CD)-1(K1)1(0)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.94000244 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.38000488 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDK10)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.90699768 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.40699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.90699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK1)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.89099884 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.26499939 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.8480072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.22200012 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.01800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PISSL)-1(RE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.96099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0011000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0017000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.15699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 173.5249939 0.75 l 173.5249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 174.5249939 -0.25 l 174.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 174.2749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 174.2749939 156.75 l h f* Q q 1 0 0 1 173.8999939 0 cm -0.625 -0.25 m 249.5249939 -0.25 l 249.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.04499817 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.11999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.61999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1210022 11.72200012 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(DK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.56799984 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.06800079 27.3220005 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.61000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.11000061 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.95200348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.45200348 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.45300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.95300293 27.3220005 Tm [(Se)-1(r)1(/)-1(Thr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.67299652 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.17300415 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.47999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.97999573 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.06799316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.56799316 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.81599426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.31599426 27.3220005 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 42.92200089 Tm [(CDK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.73699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.23699951 42.92200089 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.77899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.27899933 42.92200089 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.70899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.20899963 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.727005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.227005 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.6210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.1210022 42.92200089 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.31599426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.81599426 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.89100647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.39100647 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.39199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 58.52199936 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.25700378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.75700378 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.59899902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.09899902 58.52199936 Tm [(S.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.45999908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.95999908 58.52199936 Tm [(ce)-1(revisiae)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.88400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.38400269 58.52199936 Tm [(cdc)-1(28,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.88900757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.38900757 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.66600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.16600037 58.52199936 Tm [(S.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.5269928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.0269928 58.52199936 Tm [(po)1(mbe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.78399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(cdc)-1(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.22800064 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.72800064 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.00500107 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.50500107 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.02299881 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.52300262 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.34200287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.84200287 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.91699982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.41699982 74.12200165 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.27100372 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.77100372 74.12200165 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.97900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.47900391 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.75700378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.25700378 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.66700745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.16700745 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.45899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.95899963 74.12200165 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(og)1(re)-1(ss)1(i)-1(o)1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.18299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.68299866 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.94499969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.44499969 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.53299713 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.03299713 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.71499634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.21499634 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.22200012 89.72200012 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.30299377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.80299377 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.87800598 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.37800598 89.72200012 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.25900269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.75900269 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.73399353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.23399353 89.72200012 Tm [(rol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.04700089 105.3219986 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.80899811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.30899811 105.3219986 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.65899658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15899658 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.43600464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.93600464 105.3219986 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.8500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.3500061 105.3219986 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.09100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.59100342 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.1519928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.6519928 105.3219986 Tm [(limited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.48599243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.98599243 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63199997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13199997 120.92199707 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.42399979 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.92399979 120.92199707 Tm [(G2-M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.58200073 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.08200073 120.92199707 Tm [(ph)1(ase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.78500366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.28500366 120.92199707 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.01699829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.51699829 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.43899536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.93899536 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.50900269 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.34199905 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.84199905 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.78199768 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28199768 136.52200317 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.44200134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.94200134 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.28900146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.78900146 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.29600525 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.79600525 136.52200317 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.48599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.98599243 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.26400757 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.76400757 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.22000122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68199921 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 173.5249939 0.75 l 173.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 174.5249939 -0.25 l 174.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 174.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 174.2749939 16.35000038 l h f* Q q 1 0 0 1 173.8999939 0 cm -0.625 -0.25 m 249.5249939 -0.25 l 249.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.8999939 0.75 m 173.8999939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.8999939 157.5 m 173.8999939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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