%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 140 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(EDEM1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 120.88600159 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 231.32600403 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -25 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -1.375 61.9640007 Tm [(ED)-1(EM1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 32.26300049 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.76300049 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.26300049 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(EDEM1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.7460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.12000275 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.77000427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.14399719 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.70300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.07699585 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.8730011 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ED)-1(EM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ED)-1(EM1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.01300049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.51300049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 185.5249939 0.75 l 185.5249939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 186.5249939 -0.25 l 186.5249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 186.2749939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 186.2749939 141.1499939 l h f* Q q 1 0 0 1 185.8999939 0 cm -0.625 -0.25 m 237.5249939 -0.25 l 237.5249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Ext)1(racts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.30599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.80599976 11.72200012 Tm [(misfo)1(l)-1(d)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.65699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.15699768 11.72200012 Tm [(glyc)-1(o)1(prot)1(ei)-1(ns,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.94700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.44700623 11.72200012 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.09399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.59399414 11.72200012 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.21499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.71499634 11.72200012 Tm [(glyc)-1(o)1(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(teins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.56599998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.06599998 27.3220005 Tm [(undergoing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.63400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.13400269 27.3220005 Tm [(pro)1(duc)-1(t)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.43499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.93499756 27.3220005 Tm [(fo)1(l)-1(d)1(in)-1(g)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.79299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.29299927 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.0039978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.5039978 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.50500488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.00500488 27.3220005 Tm [(cal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ne)-1(x)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.15500069 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.65500069 42.92200089 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.11299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.61299896 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.61199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.11199951 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.67299652 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.17299652 42.92200089 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.89299774 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.39299774 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.76199341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.26199341 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.20300293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.70300293 42.92200089 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.45899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.95899963 42.92200089 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(etic)-1(ulum-a)1(ssoci)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.30899811 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.80899811 58.52199936 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.58700562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.08700562 58.52199936 Tm [(\(ERA)1(D\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.11000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.61000061 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.88699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.38699341 58.52199936 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 74.12200165 Tm [(misfo)1(l)-1(d)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.51699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.01699829 74.12200165 Tm [(glyc)-1(o)1(prot)1(ei)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.63999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.13999939 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.41799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.91799927 74.12200165 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.69599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.19599915 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.13699341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.63699341 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.15800476 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.65800476 74.12200165 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(-g)1(ly)-1(can-independen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.70300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.20300293 89.72200012 Tm [(manne)-1(r)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.41200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.91200256 89.72200012 Tm [(pro)1(bab)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.44799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.94799805 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.46000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.96000671 89.72200012 Tm [(fo)1(rmin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.3690033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 105.3219986 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.95399857 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.45399857 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.84999847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.34999847 105.3219986 Tm [(SEL1)-1(L.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.1740036 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.6740036 105.3219986 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.67299652 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.17299652 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.85499573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.35499573 105.3219986 Tm [(low)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.57800293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.07800293 105.3219986 Tm [(mannosida)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.86399841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.36399841 105.3219986 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ivity,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.79700089 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.29700089 120.92199707 Tm [(cata)1(l)-1(yzing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.39399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.89399719 120.92199707 Tm [(mannose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.38800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.88800049 120.92199707 Tm [(tr)1(i)-1(mming)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.63699341 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.13699341 120.92199707 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.8480072 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.3480072 120.92199707 Tm [(Man8Glc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(NAc2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.44000053 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.94000053 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.01499939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.51499939 136.52200317 Tm [(Man7Glc)-1(NA)1(c)-1(2.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.31500244 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q 1 g 0.375 0.75 m 185.5249939 0.75 l 185.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.5249939 -0.25 l 186.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 186.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 186.2749939 16.35000038 l h f* Q q 1 0 0 1 185.8999939 0 cm -0.625 -0.25 m 237.5249939 -0.25 l 237.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q 1 g 0.375 0.75 m 185.5249939 0.75 l 185.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 186.5249939 -0.25 l 186.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 186.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 186.2749939 16.35000038 l h f* Q q 1 0 0 1 185.8999939 0 cm -0.625 -0.25 m 237.5249939 -0.25 l 237.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(EDE)1(M1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.8999939 0.75 m 185.8999939 141.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.8999939 141.8999939 m 185.8999939 157.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 185.8999939 158.25 m 185.8999939 173.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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