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[(  )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK8)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 106.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 108.94300079 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 134.59300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 136.96699524 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 180.52600098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 182.8999939 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 220.69599915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  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12.82499981 Tm /GS2 gs 0 g [(CDK8)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 85.83499908 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019001A001B001C>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D001E001F000E>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0022>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001F0024>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 84 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAADC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 87 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 163.0249939 0.75 l 163.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 164.0249939 -0.25 l 164.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 163.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 163.7749939 172.3500061 l h f* Q q 1 0 0 1 163.3999939 0 cm -0.625 -0.25 m 260.0249939 -0.25 l 260.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cy)-1(clin)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 75.04499817 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 79.54499817 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P 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42.92200089 Tm [(members)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 52.0890007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 56.5890007 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 70.10700226 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 74.60700226 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 101.00099945 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 105.50099945 42.92200089 Tm [(similar)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 133.69599915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 138.19599915 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 147.27099609 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 151.77099609 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 165.77200317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 170.27200317 42.92200089 Tm [(gene)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 191.78799438 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 196.28799438 42.92200089 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 234.52900696 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 239.02900696 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 247.8710022 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Sacc)-1(ha)1(romyc)-1(es)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 65.85199738 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 70.35199738 58.52199936 Tm [(ce)-1(revisiae)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 112.27600098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 116.77600098 58.52199936 Tm [(cdc)-1(28,)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 144.28100586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 148.78100586 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 165.05799866 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 169.55799866 58.52199936 Tm [(Sc)-1(h)1(izosaccharo)1(my)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ce)-1(s)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 13.78600025 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 18.2859993 74.12200165 Tm [(po)1(mbe)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 49.04299927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 53.54299927 74.12200165 Tm [(cdc)-1(2,)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 75.77100372 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 80.27100372 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 96.54799652 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 101.04799652 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 114.56600189 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 119.06600189 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 147.88499451 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 152.38499451 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 161.46000671 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 165.96000671 74.12200165 Tm [(be)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 176.81399536 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 181.31399536 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 224.2749939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 228.7749939 74.12200165 Tm [(regul)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(at)1(ors)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 21.65200043 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 26.15200043 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 34.99399948 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 39.49399948 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 53.90399933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 58.40399933 89.72200012 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 79.69599915 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 84.19599915 89.72200012 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 137.56300354 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 142.06300354 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 159.32499695 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 163.82499695 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 190.91299438 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 195.41299438 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 211.69000244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 216.19000244 89.72200012 Tm [(its)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 226.10400391 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 230.60400391 89.72200012 Tm [(regu)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(lat)1(ory)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 24.64500046 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 29.14500046 105.3219986 Tm [(subunit)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 61.44499969 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 65.94499969 105.3219986 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 90.07099915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 94.57099915 105.3219986 Tm [(C)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 100.59200287 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 105.09200287 105.3219986 Tm [(are)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 118.61000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 123.11000061 105.3219986 Tm [(components)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 176.96499634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 181.46499634 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 190.30700684 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 194.80700684 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 208.80799866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 213.30799866 105.3219986 Tm [(RNA)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 232.83299255 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 237.33299255 105.3219986 Tm [(po)1(l)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(yme)-1(ra)1(se)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 35.98699951 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 40.48699951 120.92199707 Tm [(II)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 45.77799988 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 50.27799988 120.92199707 Tm [(ho)1(l)-1(o)1(e)-1(nzyme)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 103.03900146 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 107.53900146 120.92199707 Tm [(complex,)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 146.18499756 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 150.68499756 120.92199707 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 175.78199768 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 180.28199768 120.92199707 Tm [(ph)1(osph)1(orylates)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 246.66600037 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 14.0010004 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 18.50099945 136.52200317 Tm [(carbo)1(xy)-1(-)1(terminal)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 91.75299835 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 96.25299835 136.52200317 Tm [(do)1(main)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 129.08000183 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 133.58000183 136.52200317 Tm [(\(CTD\))] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 157.6269989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 162.1269989 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 170.96899414 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 175.46899414 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 189.47000122 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 193.97000122 136.52200317 Tm [(larg)1(e)-1(st)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 223.15800476 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 227.65800476 136.52200317 Tm [(subu)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nit)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 11.29399967 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 15.79399967 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 24.63599968 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 29.13599968 152.12199402 Tm [(RNA)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 48.6609993 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 53.1609993 152.12199402 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 103.01300049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 107.51300049 152.12199402 Tm [(II.)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 114.97100067 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 119.47100067 152.12199402 Tm [(This)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 136.73300171 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 141.23300171 152.12199402 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 168.32099915 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 172.82099915 152.12199402 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 187.50300598 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 192.00300598 152.12199402 Tm [(also)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 209.25999451 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 213.75999451 152.12199402 Tm [(been)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 235.26699829 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 239.76699829 152.12199402 Tm [(sh)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ow)1(n)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 18.37400055 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 22.87400055 167.72200012 Tm [(to)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 31.9489994 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 36.44900131 167.72200012 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 72.12400055 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 76.62400055 167.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 131.20799255 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 135.70799255 167.72200012 Tm [(by)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 146.22000122 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 150.72000122 167.72200012 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 190.397995 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 194.897995 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 208.89900208 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 213.39900208 167.72200012 Tm [(CDK)1(7)-1(/c)-1(y)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 163.3999939 0.75 m 163.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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