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[<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CDK6)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.08499908 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.58500671 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 180.33500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK6)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 106.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 108.94300079 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 134.59300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 136.96699524 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 180.52600098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 182.8999939 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 220.69599915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLST)-1(IRE)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 96.25299835 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK6)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 85.83499908 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 74 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 154.7749939 172.3500061 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(c)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(yc)-1(lin-d)1(e)-1(pendent)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 70.53199768 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 75.03199768 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 106.33899689 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 110.83899689 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 137.92700195 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 142.42700195 27.3220005 Tm [(\(CDK)1(\))] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 167.02799988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 171.52799988 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 199.77600098 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 204.27600098 27.3220005 Tm [(CDK)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 222.86500549 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 227.36500549 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 253.44700623 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(members)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 40.43000031 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 44.93000031 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 58.44800186 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 62.94800186 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 89.34200287 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 93.84200287 42.92200089 Tm [(similar)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 122.03700256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 126.53700256 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 135.61199951 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 140.11199951 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 154.11300659 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 158.61300659 42.92200089 Tm [(gene)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 180.1289978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 184.6289978 42.92200089 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 222.86999512 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 227.36999512 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 236.21200562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 240.71200562 42.92200089 Tm [(Sacc)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ha)1(romyc)-1(es)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 46.6570015 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 51.1570015 58.52199936 Tm [(ce)-1(revisiae)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 93.08100128 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 97.58100128 58.52199936 Tm [(cdc)-1(28,)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 125.08599854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 129.58599854 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 145.86300659 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 150.36300659 58.52199936 Tm [(Sc)-1(h)1(izosaccharo)1(my)-1(ce)-1(s)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 242.97799683 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 247.47799683 58.52199936 Tm [(po)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mbe)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 19.28800011 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 23.78800011 74.12200165 Tm [(cdc)-1(2,)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 46.01599884 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 50.51599884 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 66.79299927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 71.29299927 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 84.81099701 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 89.31099701 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 118.12999725 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 122.62999725 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 131.70500183 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 136.20500183 74.12200165 Tm [(be)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 147.05900574 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 151.55900574 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 194.52000427 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 199.02000427 74.12200165 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 242.91299438 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 247.41299438 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 256.25500488 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 14.40999985 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 18.90999985 89.72200012 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 40.20199966 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 44.70199966 89.72200012 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 98.06900024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 102.56900024 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 119.83100128 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 124.33100128 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 151.41900635 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 155.91900635 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 162.47999573 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 166.97999573 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 171.95500183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 176.45500183 89.72200012 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 211.69000244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 216.19000244 89.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 248.49000549 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 252.99000549 89.72200012 Tm [(o)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(f)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 3.11999989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 7.61999989 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 21.62100029 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 26.12100029 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 57.4280014 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 61.9280014 105.3219986 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 89.01599884 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 93.51599884 105.3219986 Tm [(complex)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 129.99499512 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 134.49499512 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 151.71699524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 156.21699524 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 162.77799988 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 167.27799988 105.3219986 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 210.23899841 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 214.73899841 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 227.01699829 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 231.51699829 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 245.92700195 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 250.42700195 105.3219986 Tm [(cy)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(cl)-1(e)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 12.01500034 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 16.51499939 120.92199707 Tm [(G1)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 28.48600006 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 32.98600006 120.92199707 Tm [(ph)1(ase)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 58.52299881 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 63.02299881 120.92199707 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 114.22399902 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 118.72399902 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 135.00100708 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 139.50100708 120.92199707 Tm [(G1/S)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 160.51100159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 165.01100159 120.92199707 Tm [(tr)1(ansition.)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 208.06399536 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 212.56399536 120.92199707 Tm [(The)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 228.3710022 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 232.8710022 120.92199707 Tm [(activit)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(y)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 4.76399994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 9.26399994 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 18.1060009 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 22.6060009 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 38.06200027 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 42.56200027 136.52200317 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 69.65000153 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 74.15000153 136.52200317 Tm [(first)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 90.6210022 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 95.1210022 136.52200317 Tm [(ap)1(pears)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 129.2749939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 133.7749939 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 141.71600342 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 146.21600342 136.52200317 Tm [(mid-)1(G1)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 178.66499329 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 183.16499329 136.52200317 Tm [(ph)1(ase,)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 210.86799622 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 215.36799622 136.52200317 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 240.46499634 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 244.96499634 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 251.52600098 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 256.02600098 136.52200317 Tm [(c)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ontr)1(olle)-1(d)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 39.43199921 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 43.93199921 152.12199402 Tm [(by)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 54.44400024 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 58.94400024 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 72.94499969 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 77.44499969 152.12199402 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 121.93499756 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 126.43499756 152.12199402 Tm [(subunits)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 162.90100098 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 167.40100098 152.12199402 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 207.25100708 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 211.75100708 152.12199402 Tm [(D-)1(type)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 241.47099304 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 245.97099304 152.12199402 Tm [(cy)-1(c)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(lins)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 14.50199986 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 19.00200081 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 35.27899933 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 39.77899933 167.72200012 Tm [(members)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 80.20899963 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 84.70899963 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 93.5510025 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 98.0510025 167.72200012 Tm [(INK4)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 119.0039978 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 123.5039978 167.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 149.58599854 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 154.08599854 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 162.92799377 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 167.42799377 167.72200012 Tm [(CDK)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 186.01699829 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 190.51699829 167.72200012 Tm [(inhibito)1(rs.)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 233.3809967 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 237.8809967 167.72200012 Tm [(This)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 255.14300537 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 0.75 m 154.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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