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-1 390.30599976 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CDK6)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 109.45999908 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 111.83399963 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Tyr)1(24\))] TJ ET EMC /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 182.83700562 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 235.33700562 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 251.08700562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 15 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 16 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK6)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 106.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 108.94300079 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Tyr)1(24\))] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 179.94599915 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 182.32000732 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 207.97000122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 210.34399414 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 253.90299988 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 256.27700806 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 294.07299805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLST)-1(IRE)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 96.25299835 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK6)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 85.83499908 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 88.20899963 12.82499981 Tm [(\(p)-1(hosp)-1(ho)-1(-Tyr)1(24\))] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 159.21200562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 86 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 87 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 145.7749939 0.75 l 145.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 146.7749939 -0.25 l 146.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 146.5249939 172.3500061 l h f* Q q 1 0 0 1 146.1499939 0 cm -0.625 -0.25 m 277.2749939 -0.25 l 277.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(cy)-1(cl)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in-dependent)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 58.86000061 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 63.36000061 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 94.66699982 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 99.16699982 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 126.25499725 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 130.75500488 27.3220005 Tm [(\(CDK)1(\))] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 155.35600281 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 159.85600281 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 188.10400391 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 192.60400391 27.3220005 Tm [(CDK)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 211.19299316 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 215.69299316 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 241.7749939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 246.2749939 27.3220005 Tm [(mem)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(bers)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 18.45700073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 22.95700073 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 36.47499847 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 40.97499847 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 67.3690033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 71.8690033 42.92200089 Tm [(similar)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 100.06400299 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 104.56400299 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 113.63899994 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 118.13899994 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 132.13999939 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 136.63999939 42.92200089 Tm [(gene)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 158.15600586 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 162.65600586 42.92200089 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 200.89700317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 205.39700317 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 214.23899841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 218.73899841 42.92200089 Tm [(Sacc)-1(ha)1(rom)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(yc)-1(es)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 18.54899979 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 23.04899979 58.52199936 Tm [(ce)-1(revisiae)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 64.97299957 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 69.47299957 58.52199936 Tm [(cdc)-1(28,)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 96.97799683 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 101.47799683 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 117.75499725 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 122.25499725 58.52199936 Tm [(Sc)-1(h)1(izosaccharo)1(my)-1(ce)-1(s)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 214.86999512 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 219.36999512 58.52199936 Tm [(po)1(mbe)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 250.1269989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 254.6269989 58.52199936 Tm [(cd)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(c2)-1(,)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 11.95800018 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 16.45800018 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 32.73500061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 37.23500061 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 50.75299835 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 55.25299835 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 84.0719986 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 88.5719986 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 97.64700317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 102.14700317 74.12200165 Tm [(be)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 113.00099945 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 117.50099945 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 160.46200562 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 164.96200562 74.12200165 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 208.85499573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 213.35499573 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 222.19700623 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 226.69700623 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 241.10699463 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 245.60699463 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 266.89898682 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 53.36700058 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 57.86700058 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 75.1289978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 79.6289978 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 106.71700287 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 111.21700287 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 117.77799988 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 122.27799988 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 127.25299835 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 131.75300598 89.72200012 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 166.98800659 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 171.48800659 89.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 203.78799438 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 208.28799438 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 217.13000488 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 221.63000488 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 235.6309967 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 240.1309967 89.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(n)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 5.546 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 10.04599953 105.3219986 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 37.13399887 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 41.63399887 105.3219986 Tm [(complex)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 78.11299896 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 82.61299896 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 99.83499908 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 104.33499908 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 110.89600372 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 115.39600372 105.3219986 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 158.35699463 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 162.85699463 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 175.13499451 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 179.63499451 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 194.04499817 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 198.54499817 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 219.83700562 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 224.33700562 105.3219986 Tm [(G1)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 236.30799866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 240.80799866 105.3219986 Tm [(ph)1(ase)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 266.34500122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 51.20100021 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 55.70100021 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 71.97799683 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 76.47799683 120.92199707 Tm [(G1/S)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 97.48799896 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 101.98799896 120.92199707 Tm [(tr)1(ansition.)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 145.04100037 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 149.54100037 120.92199707 Tm [(The)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 165.3480072 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 169.8480072 120.92199707 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 200.32000732 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 204.82000732 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 213.66200256 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 218.16200256 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 233.61799622 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 238.11799622 120.92199707 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 265.20599365 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(first)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 16.47100067 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 20.97100067 136.52200317 Tm [(ap)1(pears)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 55.125 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 59.625 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 67.56600189 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 72.06600189 136.52200317 Tm [(mid-)1(G1)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 104.51499939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 109.01499939 136.52200317 Tm [(ph)1(ase,)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 136.71800232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 141.21800232 136.52200317 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 166.31500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 170.81500244 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 177.37600708 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 181.87600708 136.52200317 Tm [(controlled)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 225.82099915 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 230.32099915 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 240.83299255 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 245.33299255 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 259.33401489 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 263.83401489 136.52200317 Tm [(r)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(egulato)1(ry)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 41.05400085 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 45.55400085 152.12199402 Tm [(subunits)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 82.01999664 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 86.51999664 152.12199402 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 126.37000275 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 130.86999512 152.12199402 Tm [(D-)1(type)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 160.58999634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 165.08999634 152.12199402 Tm [(cy)-1(clin)-1(s)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 193.38200378 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 197.88200378 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 214.15899658 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 218.65899658 152.12199402 Tm [(members)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 259.08898926 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 8.84200001 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 13.34200001 167.72200012 Tm [(INK4)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 34.29499817 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 38.79499817 167.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 64.8769989 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 69.3769989 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 78.21900177 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 82.71900177 167.72200012 Tm [(CDK)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 101.30799866 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 105.80799866 167.72200012 Tm [(inhibito)1(rs.)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 148.67199707 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 153.17199707 167.72200012 Tm [(This)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 170.43400574 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 174.93400574 167.72200012 Tm [(ki)-1(na)1(se)-1(,)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 204.18800354 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 208.68800354 167.72200012 Tm [(as)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 217.82899475 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 222.32899475 167.72200012 Tm [(well)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 239.33099365 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 243.83099365 167.72200012 Tm [(as)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 252.97200012 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 257.47198486 167.72200012 Tm [(C)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.1499939 0.75 m 146.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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