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[<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDK5)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 101.58499908 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 154.08500671 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 169.83500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK5)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 106.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 108.94300079 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 134.59300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 136.96699524 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 180.52600098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 182.8999939 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 220.69599915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PSS)-1(A)1(L)-1(RE)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 99.39099884 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK5)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 85.83499908 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 70 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 74 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 162.2749939 125.55000305 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 76 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cyc)-1(lin-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 76.5530014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 81.0530014 11.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 112.30699921 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 116.80699921 11.72200012 Tm [(\(CDK)1(s\))] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 145.57400513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 150.07400513 11.72200012 Tm [(are)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 163.59199524 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 168.09199524 11.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 239.44599915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 243.94599915 11.72200012 Tm [(ki)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nases)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 23.95899963 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 28.45899963 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 45.68099976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 50.18099976 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 63.69900131 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 68.1989975 27.3220005 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 107.34999847 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 111.84999847 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 122.36199951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 126.86199951 27.3220005 Tm [(cy)-1(clin)-1(s)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 155.15400696 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 159.65400696 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 175.93099976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 180.43099976 27.3220005 Tm [(go)1(ve)-1(rn)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 210.7230072 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 215.2230072 27.3220005 Tm [(eu)-1(karyot)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ic)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 6.90799999 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 11.40799999 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 25.81800079 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 30.31800079 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 51.61000061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 56.11000061 42.92200089 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 109.47699738 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 113.97699738 42.92200089 Tm [(Wh)1(il)-1(e)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 138.57299805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 143.07299805 42.92200089 Tm [(CDK)1(5)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 166.94000244 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 171.44000244 42.92200089 Tm [(sha)1(re)-1(s)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 198.83099365 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 203.33099365 42.92200089 Tm [(hig)1(h)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 222.56599426 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 227.06599426 42.92200089 Tm [(seque)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nc)-1(e)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 15.16600037 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 19.66600037 58.52199936 Tm [(ho)1(mology)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 63.72100067 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 68.22100067 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 86.61699677 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 91.11699677 58.52199936 Tm [(its)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 101.03099823 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 105.53099823 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 131.61300659 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 136.11300659 58.52199936 Tm [(members,)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 178.70899963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 183.20899963 58.52199936 Tm [(it)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 188.95700073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 193.45700073 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 200.01800537 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 204.51800537 58.52199936 Tm [(th)1(ought)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 239.33099365 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 243.83099365 58.52199936 Tm [(m)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ainly)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 20.0739994 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 24.5739994 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 33.64899826 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 38.14899826 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 73.88999939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 78.38999939 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 86.33100128 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 90.83100128 74.12200165 Tm [(po)1(stmito)1(tic)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 139.98399353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 144.48399353 74.12200165 Tm [(ne)-1(uro)1(n)-1(s)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 179.55200195 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 184.05200195 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 193.1269989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 197.6269989 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 233.30200195 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 237.80200195 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 251.80299377 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(cy)-1(t)1(oarchit)1(e)-1(cture)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 69.6269989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 74.1269989 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 82.96900177 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 87.46900177 89.72200012 Tm [(th)1(e)-1(se)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 110.74199677 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 115.24199677 89.72200012 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 135.98399353 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 140.48399353 89.72200012 Tm [(Analo)1(gous)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 186.64399719 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 191.14399719 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 200.21899414 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 204.71899414 89.72200012 Tm [(cy)-1(clin)-1(s,)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 235.17700195 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 239.67700195 89.72200012 Tm [(th)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 54.09600067 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 58.59600067 105.3219986 Tm [(subunits)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 95.06199646 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 99.56199646 105.3219986 Tm [(p35)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 115.86599731 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 120.36599731 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 136.64300537 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 141.14300537 105.3219986 Tm [(p39)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 157.44700623 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 161.94700623 105.3219986 Tm [(asso)1(c)-1(iat)1(e)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 201.31799316 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 205.81799316 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 224.21400452 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 228.71400452 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 244.99099731 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(activat)1(e)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 33.39400101 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 37.89400101 120.92199707 Tm [(CDK)1(5)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 61.76100159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 66.26100159 120.92199707 Tm [(despit)1(e)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 97.89299774 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 102.39299774 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 116.39399719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 120.89399719 120.92199707 Tm [(lack)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 137.67700195 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 142.17700195 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 151.01899719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 155.51899719 120.92199707 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 196.36599731 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 200.86599731 120.92199707 Tm [(ho)1(mology.)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 247.08799744 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 207 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 208 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 209 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 215 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 220 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 221 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDK)1(5)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 23.86700058 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 223 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 224 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 225 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(CDK)1(5)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 140.21299744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 0.75 m 161.8999939 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 126.30000305 m 161.8999939 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 142.65000916 m 161.8999939 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 159.00001526 m 161.8999939 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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