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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 98.46399689 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 148.13999939 23.67700005 Tm 0 Tr [(ECM1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 206.39500427 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 316.83499146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.18499756 12.82499981 Tm [(ECM1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.83499908 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.33500671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ECM1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.75800323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.13200378 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.78199768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.15600586 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.71499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.08900452 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.88499451 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(URBW)1(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.9509964 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ECM1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.02500153 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019001A001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D001E001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001F0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAADC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 166.7749939 172.3500061 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(soluble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.2480011 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.55499268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.05499268 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.2769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.7769928 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.33799744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.83799744 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.20700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.70700073 11.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(en)-1(d)1(ochondra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.06199646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.56199646 27.3220005 Tm [(bo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.68399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.18399811 27.3220005 Tm [(fo)1(rmatio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.05200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.55200195 27.3220005 Tm [(angio)1(gen)-1(esis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.35499573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.85499573 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.13200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.63200378 27.3220005 Tm [(tu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5909996 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.0909996 42.92200089 Tm [(biolo)1(gy.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.75899887 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.25899887 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.25800323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.75800323 42.92200089 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.01499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.51499939 42.92200089 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.35899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.85899353 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.25500488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.75500488 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.72999573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.22999573 42.92200089 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.98300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.48300171 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.32499695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.82499695 42.92200089 Tm [(extra)1(c)-1(el)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(lular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74699974 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.24699974 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.52399826 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.02399826 58.52199936 Tm [(st)1(ruc)-1(tura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.7440033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.2440033 58.52199936 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.88300323 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.38299561 58.52199936 Tm [(contribut)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.69299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.19299316 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.26800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.76800537 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.76899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.26899719 58.52199936 Tm [(maint)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(en)-1(a)1(n)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.79199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.29199982 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.13399887 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.63399887 74.12200165 Tm [(skin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.64099884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.14099884 74.12200165 Tm [(integrit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.2460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.7460022 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.02300262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.522995 74.12200165 Tm [(ho)1(me)-1(os)1(tasis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.43499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.93499756 74.12200165 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.78399658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.28399658 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.2250061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.47200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97200012 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.49000168 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.99000168 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.11699677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.61699677 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.01300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.51300049 89.72200012 Tm [(lipoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.92500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.42500305 89.72200012 Tm [(pro)1(tein)-1(o)1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.17999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.67999268 89.72200012 Tm [(diso)1(rd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 105.3219986 Tm [(\(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.30599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.80599976 105.3219986 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.625 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.125 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26599884 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.76599884 105.3219986 Tm [(hyalinosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.83000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.33000183 105.3219986 Tm [(cu)-1(t)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.30299377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.80299377 105.3219986 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.26199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.76199341 105.3219986 Tm [(muc)-1(o)1(sae)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.2230072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.7230072 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.8809967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.3809967 105.3219986 Tm [(Ur)1(ba)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ch-W)1(ie)-1(t)1(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.60900116 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.10900116 120.92199707 Tm [(disease\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.78600311 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.28600311 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.50800323 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.00800323 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.56900024 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.06900024 120.92199707 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.602005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.102005 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.61399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.11399841 120.92199707 Tm [(gene)-1(r)1(alize)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.1190033 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(th)1(ic)-1(ke)-1(ning)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.0530014 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.5530014 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.39500046 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.89500046 136.52200317 Tm [(skin)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.06800079 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.56800079 136.52200317 Tm [(muc)-1(o)1(sae)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.02899933 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.52900696 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.80599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.30599976 136.52200317 Tm [(ce)-1(rt)1(ain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.6309967 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.1309967 136.52200317 Tm [(visce)-1(ra)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.61300659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.11300659 136.52200317 Tm [(Alt)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(at)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.71199989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.2120018 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.29299927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.79299927 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.71499634 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.21499634 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.78500366 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.28500366 152.12199402 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.6269989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.1269989 152.12199402 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.60499573 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.10499573 152.12199402 Tm [(isof)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.75699997 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.25699997 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.60400009 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.10400009 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.61100006 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.11100006 167.72200012 Tm [(described)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.09600067 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.59600067 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.87399292 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.37399292 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.83000183 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.33000183 167.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.01199341 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 0.75 m 166.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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