%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(ECHS1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 112.98000336 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 223.41999817 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 234.41999817 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -66 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -66 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -13.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.125 61.9640007 Tm [(ECH)-1(S1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 40.16400146 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 92.66400146 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.91400146 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ECHS)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.14700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.52100372 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.17100525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.54499817 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.10400391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.47799683 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.27400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SC)-1(EH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09200287 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ECH)-1(S1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.41400146 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 157.0249939 0.75 l 157.0249939 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 158.0249939 -0.25 l 158.0249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 157.7749939 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 157.7749939 125.55000305 l h f* Q q 1 0 0 1 157.3999939 0 cm -0.625 -0.25 m 266.0249939 -0.25 l 266.0249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.01199341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.51199341 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.45300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.95300293 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.95399475 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.45399475 11.72200012 Tm [(sec)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 27.3220005 Tm [(st)1(e)-1(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.17699814 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.67699814 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.51900101 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.01900101 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.01999664 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.51999664 27.3220005 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.70300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.20300293 27.3220005 Tm [(fa)1(tty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.76699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.26699829 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.40699768 27.3220005 Tm [(beta)1(-oxid)1(atio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.90800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.40800476 27.3220005 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(hwa)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.88000107 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.38000107 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.37900162 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.87900162 42.92200089 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.5510025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.0510025 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.05200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.55200195 42.92200089 Tm [(hydra)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.04100037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.54100037 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.38299561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.88299561 42.92200089 Tm [(2-tr)1(ans-enoy)-1(l-)1(c)-1(o)1(e)-1(nz)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(yme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.3029995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.8029995 58.52199936 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13599968 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.63600159 58.52199936 Tm [(\(CoA)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.72200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.22200012 58.52199936 Tm [(intermediates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.34999847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84999847 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.92500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42500305 58.52199936 Tm [(L-3-hydr)1(oxyacy)-1(l-)1(CoAs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.60099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.10099792 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.9079895 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 74.12200165 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.0909996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.59100342 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.15200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.65200043 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.6269989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.1269989 74.12200165 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.39099884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.89099884 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.73300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.23300171 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.23399353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.73399353 74.12200165 Tm [(hydra)1(tas)1(e)-1(/isomerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.15800476 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.65800476 74.12200165 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(uperfamily.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.08499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.58499908 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58399963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.08399963 89.72200012 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.1760025 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.6760025 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.75099945 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.25099945 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.2519989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.7519989 89.72200012 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.93499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.43499756 89.72200012 Tm [(mat)1(rix.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.75500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.25500488 89.72200012 Tm [(Trans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(cript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.51599884 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.01599884 105.3219986 Tm [(utilizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.22299957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.72299957 105.3219986 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.08799744 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.58799744 105.3219986 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.17199707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.67199707 105.3219986 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2460022 105.3219986 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ites)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02099991 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52099991 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.86800003 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.36800003 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.875 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.375 120.92199707 Tm [(described)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.36000061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.86000061 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.8010025 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.30099487 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.30200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.80200195 120.92199707 Tm [(literat)1(u)-1(r)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07099915 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 157.0249939 0.75 l 157.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 158.0249939 -0.25 l 158.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 157.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 157.7749939 16.35000038 l h f* Q q 1 0 0 1 157.3999939 0 cm -0.625 -0.25 m 266.0249939 -0.25 l 266.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 157.0249939 0.75 l 157.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 158.0249939 -0.25 l 158.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 157.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 157.7749939 16.35000038 l h f* Q q 1 0 0 1 157.3999939 0 cm -0.625 -0.25 m 266.0249939 -0.25 l 266.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ECHS1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.40200043 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 157.0249939 0.75 l 157.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 158.0249939 -0.25 l 158.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 157.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 157.7749939 16.35000038 l h f* Q q 1 0 0 1 157.3999939 0 cm -0.625 -0.25 m 266.0249939 -0.25 l 266.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(ECHS1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.7480011 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.3999939 0.75 m 157.3999939 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.3999939 126.30000305 m 157.3999939 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.3999939 142.65000916 m 157.3999939 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.3999939 159.00001526 m 157.3999939 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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