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)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 131.46600342 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 157.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 159.49000549 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 203.04899597 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 205.42300415 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 243.21899414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C53;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 82.05200195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 84.4260025 12.82499981 Tm [(IC53;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 106.1230011 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 108.49700165 12.82499981 Tm [(LZ)-1(A)1(P;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 132.13699341 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 134.51100159 12.82499981 Tm [(HS)-1(F-27;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 167.36999512 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 169.7440033 12.82499981 Tm [(MST)-1(01)1(6;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 207.43699646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 209.81100464 12.82499981 Tm [(PP)1(1553;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 244.7559967 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 247.13000488 12.82499981 Tm [(OK/SW-cl.)-1(114)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 306.43899536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK5RA)1(P3)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 108.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 84 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 177.5249939 -0.25 l 177.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 177.2749939 125.55000305 l h f* Q q 1 0 0 1 176.8999939 0 cm -0.625 -0.25 m 246.5249939 -0.25 l 246.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 169.8809967 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 174.3809967 11.72200012 Tm [(been)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 195.88800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 200.38800049 11.72200012 Tm [(repor)1(ted)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 238.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 9.07499981 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 13.57499981 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 49.31600189 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 53.81600189 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 61.75699997 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 66.25700378 27.3220005 Tm [(signaling)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 105.18800354 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 109.68800354 27.3220005 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 150.31500244 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 154.81500244 27.3220005 Tm [(go)1(ve)-1(rning)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 198.80400085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 203.30400085 27.3220005 Tm [(tr)1(ansc)-1(ri)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pt)1(ional)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 30.13299942 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 34.63299942 42.92200089 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 78.86399841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 83.36399841 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 99.64099884 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 104.14099884 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 118.5510025 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 123.0510025 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 144.34300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 148.84300232 42.92200089 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 202.21000671 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 206.71000671 42.92200089 Tm [(It)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 212.70899963 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 217.20899963 42.92200089 Tm [(may)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 235.38000488 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(play)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 17.88100052 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 22.38100052 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 27.3560009 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 31.8560009 58.52199936 Tm [(role)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 48.51599884 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 53.01599884 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 60.95700073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 65.45700073 58.52199936 Tm [(tumor)1(ige)-1(nesis)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 126.58499908 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 131.08500671 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 147.36199951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 151.86199951 58.52199936 Tm [(metast)1(asis.)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 199.11599731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 203.61599731 58.52199936 Tm [(A)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 209.94900513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 214.44900513 58.52199936 Tm [(pseu)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(do)1(gen)-1(e)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 32.99399948 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 37.49399948 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 46.33599854 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 50.83599854 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 66.29199982 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 70.79199982 74.12200165 Tm [(gene)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 92.30799866 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 96.80799866 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 103.3690033 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 107.8690033 74.12200165 Tm [(located)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 139.69000244 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 144.19000244 74.12200165 Tm [(on)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 155.45799255 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 159.95799255 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 173.95899963 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 178.45899963 74.12200165 Tm [(long)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 197.87800598 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 202.37800598 74.12200165 Tm [(arm)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 219.22200012 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 223.72200012 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 232.56399536 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 56.79499817 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 61.29499817 89.72200012 Tm [(20)-1(.)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 74.01699829 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 78.51699829 89.72200012 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 125.23999786 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 129.74000549 89.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 162.65499878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 167.15499878 89.72200012 Tm [(results)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 195.32400513 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 199.82400513 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 207.76499939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 212.26499939 89.72200012 Tm [(multi)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ple)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 13.25 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 17.75 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 58.67200089 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 63.17200089 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 96.74199677 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 101.24199677 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 118.46399689 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 122.96399689 105.3219986 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 154.71400452 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 159.21400452 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 196.15400696 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 200.65400696 105.3219986 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(.)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 2.16700006 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.5249939 -0.25 l 177.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 204 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 205 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm -0.625 -0.25 m 246.5249939 -0.25 l 246.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 206 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.5249939 -0.25 l 177.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 212 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 217 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm -0.625 -0.25 m 246.5249939 -0.25 l 246.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 218 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(CDK)1(5)-1(RA)1(P3)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 46.85900116 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.5249939 -0.25 l 177.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 220 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 221 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm -0.625 -0.25 m 246.5249939 -0.25 l 246.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 222 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(CDK)1(5)-1(RA)1(P3)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 163.20500183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 0.75 m 176.8999939 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 126.30000305 m 176.8999939 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 142.65000916 m 176.8999939 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 159.00001526 m 176.8999939 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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