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5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT 1 0 0 -1 -35.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -11.875 61.9640007 Tm [(CDK5R1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 24.60800171 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 77.10800171 61.9640007 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 82.35800171 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK5)1(R1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 117.59200287 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 119.96600342 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 145.61599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 147.99000549 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 191.54899597 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 193.92300415 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 231.71899414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(p23;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 81.97000122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 84.34400177 12.82499981 Tm [(p25;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 103.31400299 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105.68800354 12.82499981 Tm [(p35;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 124.65799713 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 127.03199768 12.82499981 Tm [(CDK5R;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 158.37800598 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 160.7519989 12.82499981 Tm [(NCK)1(5A;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 192.78999329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 195.16400146 12.82499981 Tm [(CDK5P)1(35;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 236.8769989 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 239.25100708 12.82499981 Tm [(p35nck5a)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 280.49200439 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK5R1)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 96.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002400250026000D>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 84 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 183.2749939 0.75 l 183.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 184.2749939 -0.25 l 184.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 184.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 184.0249939 172.3500061 l h f* Q q 1 0 0 1 183.6499939 0 cm -0.625 -0.25 m 239.7749939 -0.25 l 239.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(\(p35)-1(\))] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 181.41999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 185.91999817 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 192.48100281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 196.98100281 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 201.95599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 206.45599365 11.72200012 Tm [(ne)-1(ur)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(on-s)1(pe)-1(cific)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 47.11800003 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 51.61800003 27.3220005 Tm [(activat)1(or)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 89.06400299 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 93.56400299 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 102.40599823 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 106.90599823 27.3220005 Tm [(cy)-1(clin)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 181.95100403 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 186.45100403 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 213.53900146 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 218.03900146 27.3220005 Tm [(5)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 223.31700134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 227.81700134 27.3220005 Tm [(\()] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(CDK)1(5)-1(\);)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 29.03899956 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 33.53900146 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 47.54000092 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 52.04000092 42.92200089 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 93.98999786 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 98.48999786 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 107.33200073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 111.83200073 42.92200089 Tm [(CDK)1(5)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 135.69900513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 140.19900513 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 146.75999451 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 151.25999451 42.92200089 Tm [(required)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 187.80099487 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 192.30099487 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 204.57899475 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 209.07899475 42.92200089 Tm [(pro)1(p)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(er)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 8.54300022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 13.04300022 58.52199936 Tm [(development)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 70.04000092 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 74.54000092 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 83.38200378 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 87.88200378 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 101.88300323 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 106.38300323 58.52199936 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 135.70799255 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 140.20799255 58.52199936 Tm [(ne)-1(r)1(vous)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 174.45500183 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 178.95500183 58.52199936 Tm [(system.)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 211.11000061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 215.61000061 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 231.41700745 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(p35)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 16.30400085 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 20.80400085 74.12200165 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 41.51499939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 46.01499939 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 54.85699844 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 59.35699844 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 74.81300354 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 79.31300354 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 110.62000275 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 115.12000275 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 121.68099976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 126.18099976 74.12200165 Tm [(pro)1(teolytically)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 187.21699524 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 191.71699524 74.12200165 Tm [(cl)-1(eaved)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 224.29400635 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 10.51200008 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 15.01200008 89.72200012 Tm [(calpain,)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 47.72499847 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 52.22499847 89.72200012 Tm [(gene)-1(r)1(ating)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 99.20300293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 103.70300293 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 108.6780014 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 113.1780014 89.72200012 Tm [(p25)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 129.48199463 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 133.98199463 89.72200012 Tm [(fo)1(rm.)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 156.86000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 161.36000061 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 177.16700745 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 181.66700745 89.72200012 Tm [(cl)-1(eava)1(ge)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 219.21800232 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 223.71800232 89.72200012 Tm [(o)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(f)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 3.11999989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 7.61999989 105.3219986 Tm [(p35)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 23.92399979 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 28.42399979 105.3219986 Tm [(into)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 45.43999863 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 49.93999863 105.3219986 Tm [(p25)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 66.2440033 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 70.7440033 105.3219986 Tm [(results)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 98.91300201 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 103.41300201 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 111.35399628 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 115.85399628 105.3219986 Tm [(reloc)-1(a)1(li)-1(z)1(at)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 173.20700073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 177.70700073 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 186.54899597 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 191.04899597 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 205.05000305 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 209.55000305 105.3219986 Tm [(pro)1(t)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ein)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 13.04699993 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 17.54700089 120.92199707 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 38.25799942 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 42.75799942 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 56.75899887 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 61.25899887 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 75.66899872 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 80.16899872 120.92199707 Tm [(periph)1(e)-1(ry)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 121.4509964 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 125.9509964 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 135.02600098 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 139.52600098 120.92199707 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 171.04400635 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 175.54400635 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 191.82099915 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 196.32099915 120.92199707 Tm [(perinuc)-1(l)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ear)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 13.51799965 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 18.01799965 136.52200317 Tm [(regions.)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 52.31299973 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 56.81299973 136.52200317 Tm [(P25)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 72.875 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 77.375 136.52200317 Tm [(deregulates)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 128.07899475 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 132.57899475 136.52200317 Tm [(CDK)1(5)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 156.44599915 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 160.94599915 136.52200317 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 191.41799927 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 195.91799927 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 206.42999268 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 210.92999268 136.52200317 Tm [(pro)1(l)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(onging)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 30.72200012 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 35.22200012 152.12199402 Tm [(its)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 45.13600159 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 49.63600159 152.12199402 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 91.58599854 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 96.08599854 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 112.36299896 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 116.86299896 152.12199402 Tm [(changing)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 156.89300537 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 161.39300537 152.12199402 Tm [(its)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 171.30700684 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 175.80700684 152.12199402 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 206.56900024 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 211.06900024 152.12199402 Tm [(loca)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(tio)1(n)-1(.)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 19.18199921 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 183.6499939 0.75 m 183.6499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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