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[<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDK4)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 101.58499908 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 154.08500671 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 169.83500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDK4)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 106.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 108.94300079 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 134.59300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 136.96699524 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 180.52600098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 182.8999939 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 220.69599915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cy)1(cl)-1(in)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 86.96900177 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 89.34300232 12.82499981 Tm [(depend)-1(e)1(n)-1(t)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 136.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 138.49000549 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 165.55000305 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 167.92399597 12.82499981 Tm [(4;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 176.05499268 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 178.42900085 12.82499981 Tm [(CMM3;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 210.11399841 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 212.48800659 12.82499981 Tm [(PSK-J3)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 240.07600403 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK4)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 85.83499908 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C001D000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F0020000F000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00210004>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700200025000D>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 81 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 82 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 177.2749939 0.75 l 177.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 178.2749939 -0.25 l 178.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 178.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 178.0249939 172.3500061 l h f* Q q 1 0 0 1 177.6499939 0 cm -0.625 -0.25 m 245.7749939 -0.25 l 245.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(t)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(he)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 10.64799976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 15.14799976 27.3220005 Tm [(Se)-1(r)1(/)-1(Thr)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 46.86800003 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 51.36800003 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 82.67500305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 87.17500305 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 114.26300049 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 118.76300049 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 147.01100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 151.51100159 27.3220005 Tm [(This)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 168.772995 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 173.272995 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 204.58000183 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 209.08000183 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 215.64100647 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 220.14100647 27.3220005 Tm [(hig)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(hly)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 12.69999981 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 17.20000076 42.92200089 Tm [(similar)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 45.39500046 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 49.89500046 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 58.97000122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 63.47000122 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 77.47100067 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 81.97100067 42.92200089 Tm [(gene)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 103.48699951 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 107.98699951 42.92200089 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 146.22799683 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 150.72799683 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 159.57000732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 164.07000732 42.92200089 Tm [(S.)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 171.43099976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 175.93099976 42.92200089 Tm [(ce)-1(revisiae)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 217.85499573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 222.35499573 42.92200089 Tm [(cdc)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(28)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 10.55599976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 15.05599976 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 31.33300018 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 35.83300018 58.52199936 Tm [(S.)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 43.19400024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 47.69400024 58.52199936 Tm [(po)1(mbe)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 78.4509964 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 82.9509964 58.52199936 Tm [(cdc)-1(2.)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 105.17900085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 109.67900085 58.52199936 Tm [(It)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 115.6780014 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 120.1780014 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 126.73899841 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 131.23899841 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 136.21400452 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 140.71400452 58.52199936 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 175.94900513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 180.44900513 58.52199936 Tm [(subunit)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 212.74899292 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 217.24899292 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 226.09100342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 230.59100342 58.52199936 Tm [(t)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(he)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 10.64799976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 15.14799976 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 46.45500183 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 50.95500183 74.12200165 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 78.04299927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 82.54299927 74.12200165 Tm [(complex)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 119.02200317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 123.52200317 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 140.7440033 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 145.2440033 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 151.80499268 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 156.30499268 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 199.26600647 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 203.76600647 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 216.04400635 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 220.54400635 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 234.95399475 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 21.29199982 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 25.79199982 89.72200012 Tm [(G1)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 37.76300049 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 42.26300049 89.72200012 Tm [(ph)1(ase)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 67.80000305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 72.30000305 89.72200012 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 125.66699982 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 130.16700745 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 145.97399902 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 150.47399902 89.72200012 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 180.94599915 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 185.44599915 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 194.28799438 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 198.78799438 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 214.2440033 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 218.7440033 89.72200012 Tm [(ki)-1(na)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(se)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 9.27200031 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 13.77200031 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 20.33300018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 24.83300018 105.3219986 Tm [(restricted)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 65.45600128 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 69.95600128 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 79.03099823 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 83.53099823 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 97.53199768 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 102.03199768 105.3219986 Tm [(G1-S)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 123.09100342 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 127.59100342 105.3219986 Tm [(ph)1(ase,)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 155.29400635 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 159.79400635 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 184.89100647 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 189.39100647 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 195.95199585 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 200.45199585 105.3219986 Tm [(controll)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(by)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 25.875 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 30.375 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 44.37599945 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 48.87599945 120.92199707 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 93.36599731 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 97.86599731 120.92199707 Tm [(subunits)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 134.33200073 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 138.83200073 120.92199707 Tm [(D-)1(type)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 168.55200195 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 173.05200195 120.92199707 Tm [(cy)-1(clin)-1(s)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 201.34399414 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 205.84399414 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 222.1210022 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 226.6210022 120.92199707 Tm [(C)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(DK)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 12.56799984 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 17.06800079 136.52200317 Tm [(inhibito)1(r)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 53.59999847 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 58.09999847 136.52200317 Tm [(p16)-1(\(I)1(NK4)-1(a)1(\).)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 108.51000214 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 113.01000214 136.52200317 Tm [(This)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 130.27200317 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 134.77200317 136.52200317 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 161.86000061 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 166.36000061 136.52200317 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 182.60699463 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 187.10699463 136.52200317 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 215.18800354 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 219.68800354 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 228.76300049 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(be)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 10.85400009 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 15.35400009 152.12199402 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 64.88899994 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 69.38899994 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 81.66699982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 86.16699982 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 100.16799927 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 104.66799927 152.12199402 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 175.44200134 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 179.94200134 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 188.78399658 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 193.28399658 152.12199402 Tm [(retinobla)1(s)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(to)1(ma)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 22.48200035 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 26.98200035 167.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 48.4980011 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 52.9980011 167.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 87.07299805 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 91.57299805 167.72200012 Tm [(\(Rb)1(\).)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 111.375 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 115.875 167.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 159.72399902 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 164.22399902 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 172.16499329 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 176.66499329 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 192.1210022 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 196.6210022 167.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 218.13699341 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 222.63699341 167.72200012 Tm [(as)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 231.77799988 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 177.6499939 0.75 m 177.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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