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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.69100189 23.67700005 Tm 0 g [(BB)1(S9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.90400696 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.90400696 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 324.60800171 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(BBS9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.56900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.81900024 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.81900024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BBS9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.56900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.94300079 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.14499664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51899719 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.49899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.8730011 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.34700012 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bardet)1(-)-1(Biedl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.51999664 12.82499981 Tm [(synd)-1(r)1(o)-1(m)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.22200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.59599304 12.82499981 Tm [(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.727005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.10099792 12.82499981 Tm [(B1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.94400024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.31799316 12.82499981 Tm [(D1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.28300476 12.82499981 Tm [(C18;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.33500671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.70899963 12.82499981 Tm [(PTHB1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.82501221 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(111-3)1(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(BBS9)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 334.29400635 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 194.17500305 16.35000038 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Bardet-)1(B)-1(iedl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.4679985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.9679985 11.72200012 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.89800262 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.39800262 11.72200012 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.6760025 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 194.17500305 16.35000038 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(B1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.0909996 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5909996 11.72200012 Tm [(D1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89100075 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.39099884 11.72200012 Tm [(C18)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.13399887 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.63399887 11.72200012 Tm [(PTHB)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.18499756 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 194.17500305 16.35000038 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q3S)-1(Y)1(G4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.20899963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 194.17500305 16.35000038 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(32)-1(71)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 194.17500305 31.95000076 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.61800003 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 194.17500305 16.35000038 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 194.17500305 16.35000038 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 193.42500305 0.75 l 193.42500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 194.42500305 -0.25 l 194.42500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 194.17500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 194.17500305 94.34999847 l h f* Q q 1 0 0 1 193.80000305 0 cm -0.625 -0.25 m 233.375 -0.25 l 233.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(do)1(wnregulated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.40100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.90100098 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.41299438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.91299438 11.72200012 Tm [(pa)1(rath)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.01499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.51499939 11.72200012 Tm [(ho)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37400055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.87400055 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.81500053 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.31499863 27.3220005 Tm [(ost)1(e)-1(o)1(blast)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.92900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.42900085 27.3220005 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.17099762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.67099762 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.94799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.44799805 27.3220005 Tm [(th)1(e)-1(r)1(e)-1(fo)1(re)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.54299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.04299927 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.60400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.10400391 27.3220005 Tm [(th)1(ough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.9279995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.4279995 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.2820015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.7820015 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.15100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.65100098 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.59200287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.09200287 42.92200089 Tm [(pa)1(rath)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.19400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.69400024 42.92200089 Tm [(ho)1(rmone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.20100403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.70100403 42.92200089 Tm [(action)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.20399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.70399475 42.92200089 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(bo)1(n)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.50099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.00099945 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.80799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.30799866 58.52199936 Tm [(exact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.81700134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.31700134 58.52199936 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.05799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.55799866 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.3999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.8999939 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.35600281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.85600281 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.37199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.87199402 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.55400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.05400085 58.52199936 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.67500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ye)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.22299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.72299957 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.22999954 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.72999954 74.12200165 Tm [(determine)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.89299774 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.39299774 74.12200165 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.27400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.77400208 74.12200165 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.85499573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.35499573 74.12200165 Tm [(tr)1(ansc)-1(ri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.10099983 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.60099983 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.17100143 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.67100143 89.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.01300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.51300049 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.45300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.95300293 89.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.11300659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.61300659 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.96000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.46000671 89.72200012 Tm [(bee)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 0.75 m 193.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 17.10000038 m 193.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 33.45000076 m 193.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 49.80000305 m 193.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 66.15000153 m 193.80000305 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 98.1000061 m 193.80000305 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 114.45000458 m 193.80000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 193.80000305 130.80000305 m 193.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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