%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 116 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.14299774 23.67700005 Tm 0 g [(BB)1(OX1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.45300293 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.15701294 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(BBOX1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.14700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.39700317 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.39700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BBOX1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.14700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.52100372 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.72299957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.09700012 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.07699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.45100403 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92500305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(gamm)1(a-)-1(butyrobetain)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.92999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.30400085 12.82499981 Tm [(hydrox)-1(y)1(l)-1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.73199463 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.86300659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.23699951 12.82499981 Tm [(BBH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.01100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.38499451 12.82499981 Tm [(BBOX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.01998901 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.39401245 12.82499981 Tm [(G-BBH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.00698853 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.38101196 12.82499981 Tm [(gamm)1(a-)-1(B)1(BH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.33700562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(188-3)1(87)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(BBOX1)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 340.78900146 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ga)1(mma-b)1(u)-1(t)1(yrobeta)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.26399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.76399994 11.72200012 Tm [(hydro)1(xylase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.95199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.45199585 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.72999573 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BB)-1(H;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.42099953 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.92099953 11.72200012 Tm [(BB)-1(OX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52099991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.02099991 11.72200012 Tm [(G-)1(B)-1(BH)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.02899933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.52899933 11.72200012 Tm [(ga)1(mma-BB)-1(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.25 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O75)-1(93)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(11)-1(03)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 106.42500305 16.35000038 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 105.67500305 0.75 l 105.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 106.67500305 -0.25 l 106.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.42500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 106.42500305 78.75 l h f* Q q 1 0 0 1 106.05000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.76699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.26699829 11.72200012 Tm [(but)1(y)-1(ro)1(betaine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.06500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.56500244 11.72200012 Tm [(hydro)1(xylase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.75300598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.25300598 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.3500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.8500061 11.72200012 Tm [(cata)1(l)-1(yz)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.77300072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.27299881 27.3220005 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.97499847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.47499847 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.31700134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.81700134 27.3220005 Tm [(L-carnitine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.59500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.09500122 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.80599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.30599976 27.3220005 Tm [(ga)1(mma-b)1(u)-1(t)1(yrobeta)1(i)-1(ne,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.73699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.23699951 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.23800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.73800659 27.3220005 Tm [(last)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.62701416 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(st)1(e)-1(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.87400055 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81500053 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.31499863 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.31600189 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.81600189 42.92200089 Tm [(L-carnitine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.59400177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.09400177 42.92200089 Tm [(bios)1(y)-1(nt)1(he)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.69700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.19700623 42.92200089 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.82499695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.32499695 42.92200089 Tm [(Carnit)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.0980072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.5980072 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.15899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.65899658 42.92200089 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.86700439 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.36700439 42.92200089 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.93799973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.43799973 58.52199936 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.17299652 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.67299652 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.01499939 58.52199936 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.16600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.66600037 58.52199936 Tm [(fa)1(tty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.22999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.72999573 58.52199936 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.53599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.03599548 58.52199936 Tm [(across)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.01400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.51400757 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.51499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.01499939 58.52199936 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.19799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.69799805 58.52199936 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mbra)1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.24499893 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.74499893 74.12200165 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.18199921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.68199921 74.12200165 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.86500549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.36500549 74.12200165 Tm [(beta)1(-oxid)1(atio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.03199768 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 0.75 m 106.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 17.10000038 m 106.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 33.45000076 m 106.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 49.80000305 m 106.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 66.15000153 m 106.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 82.5 m 106.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 98.84999847 m 106.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.05000305 115.19999695 m 106.05000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 423.17498779 193.57499695 l S Q Q q 1 0 0 1 0 586.86199951 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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