%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 101 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.57700348 23.67700005 Tm 0 g [(BAA)1(LC)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.01800537 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.72198486 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(BAA)1(L)-1(C)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 93.5 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BAA)1(L)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.875 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.24900055 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.4509964 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.82499695 12.82499981 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.00900269 12.82499981 Tm [(Rec)1(o)-1(mbin)-1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.80499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.17900085 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.65299988 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.52500153 16.35000038 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(bra)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.10000038 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.60000038 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.8769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.3769989 11.72200012 Tm [(acute)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.87000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.37000275 11.72200012 Tm [(leu)-1(ke)-1(mia)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.39299774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.89299774 11.72200012 Tm [(cy)-1(t)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.86999512 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.52500153 16.35000038 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WXS3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.04800034 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.52500153 16.35000038 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(11)-1(51)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.52500153 16.35000038 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.52500153 16.35000038 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.52500153 16.35000038 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 112.77500153 0.75 l 112.77500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 113.77500153 -0.25 l 113.77500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.52500153 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 113.52500153 109.94999695 l h f* Q q 1 0 0 1 113.15000153 0 cm -0.625 -0.25 m 314.0249939 -0.25 l 314.0249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(wa)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.02500153 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.52500153 11.72200012 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.45600128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.95600128 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.46800232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.96800232 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.48399353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.98399353 11.72200012 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.93800354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.43800354 11.72200012 Tm [(st)1(u)-1(d)1(ie)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.42700195 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.86799622 11.72200012 Tm [(pa)1(tien)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.51000977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.01000977 11.72200012 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 27.3220005 Tm [(acute)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.53499985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.03499985 27.3220005 Tm [(mye)-1(loid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.60700226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.10700226 27.3220005 Tm [(leu)-1(ke)-1(mia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.96299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.46299744 27.3220005 Tm [(\(AML\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.38600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.88600159 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.69299316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.19299316 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.70899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.20899963 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.77000427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.27000427 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.84698486 27.3220005 Tm [(amo)1(n)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.2789917 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.7789917 27.3220005 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(amma)1(l)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.37599945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.87599945 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.15299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.65299988 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21399689 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71399689 42.92200089 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.33499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.83499908 42.92200089 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52500153 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.02500153 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.46600342 42.92200089 Tm [(low)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.23199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.73199463 42.92200089 Tm [(org)1(anisms.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.4940033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.9940033 42.92200089 Tm [(Tissue)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.69900513 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.19900513 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.42098999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.92098999 42.92200089 Tm [(express)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.21200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97200012 58.52199936 Tm [(develop)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.53099823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.03099823 58.52199936 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.74199677 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.24199677 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.24299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.74299622 58.52199936 Tm [(ne)-1(uro)1(e)-1(ctod)1(e)-1(r)1(m.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.69299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.19299316 58.52199936 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.92500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.42500305 58.52199936 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.94799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.44799805 58.52199936 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(plice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.91500092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.41500092 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.33699799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.83699799 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.40699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.90699768 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.1289978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.6289978 74.12200165 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.3789978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.8789978 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.81900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.31900024 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.79200745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.29200745 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.63900757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.13900757 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.64599609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(described)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.98500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.48500061 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.76300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.26300049 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.71900177 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.21900177 89.72200012 Tm [(gene)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.90100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.40100098 89.72200012 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.30999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.80999756 89.72200012 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.23699951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.73699951 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.57899475 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.07899475 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.08000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.58000183 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.5019989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.00201416 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.57199097 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.07199097 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 105.3219986 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.73300171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.23300171 105.3219986 Tm [(only)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.6590004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.15899658 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.09999847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.59999847 105.3219986 Tm [(AML)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.34500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.84500122 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.25499725 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.75499725 105.3219986 Tm [(line)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.52999878 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.04998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 0.75 m 113.15000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 17.10000038 m 113.15000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 33.45000076 m 113.15000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 49.80000305 m 113.15000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 66.15000153 m 113.15000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 82.5 m 113.15000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.15000153 98.84999847 m 113.15000153 208.04998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.04998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 208.42498779 m 426.92498779 208.42498779 l S Q Q q 1 0 0 1 0 558.39001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>