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/GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CDC)-1(4)1(2/)-1(RHO/RA)1(C)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 162.23199463 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 214.73199463 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 225.23199463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC42/RHO/)-1(R)1(AC)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 156.71600342 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 159.08999634 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 184.74000549 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 187.11399841 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 230.67300415 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 233.04699707 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 270.84298706 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(G25K)1(,)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 88.34300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 90.71700287 12.82499981 Tm [(CDC)-1(4)1(2Hs)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 129.66600037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Cd)-1(c)1(42/Rh)-1(oA/Rac1)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 140.63200378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 78 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 81 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 166.7749939 0.75 l 166.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 167.7749939 -0.25 l 167.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 167.5249939 172.3500061 l h f* Q q 1 0 0 1 167.1499939 0 cm -0.625 -0.25 m 256.2749939 -0.25 l 256.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 84 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(small)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 202.00500488 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 206.50500488 11.72200012 Tm [(GTPa)1(se)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 238.11000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 27.34300041 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 31.84300041 27.3220005 Tm [(Rho)1(-subf)1(amily)-1(,)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 96.58300018 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 101.08300018 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 126.18000031 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 130.67999268 27.3220005 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 170.52099609 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 175.02099609 27.3220005 Tm [(signaling)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 213.95199585 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 218.45199585 27.3220005 Tm [(pa)1(thw)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ays)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 13.90400028 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 18.40399933 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 35.62599945 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 40.12599945 42.92200089 Tm [(control)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 70.81300354 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 75.31300354 42.92200089 Tm [(diverse)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 106.0039978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 110.5039978 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 141.26600647 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 145.76600647 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 185.67300415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 190.17300415 42.92200089 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 230.022995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 234.522995 42.92200089 Tm [(ce)-1(l)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(l)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 2.39499998 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 6.89499998 58.52199936 Tm [(morp)1(holog)1(y)-1(,)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 62.30099869 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 66.8010025 58.52199936 Tm [(migra)1(tion,)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 110.97899628 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 115.47899628 58.52199936 Tm [(en)-1(d)1(ocy)-1(t)1(osis)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 166.68800354 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 171.18800354 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 187.46499634 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 191.96499634 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 206.375 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 210.875 58.52199936 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 232.16700745 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 236.66700745 58.52199936 Tm [(pr)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(og)1(re)-1(ss)1(i)-1(o)1(n.)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 44.18299866 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 48.68299866 74.12200165 Tm [(This)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 65.94499969 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 70.44499969 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 101.7519989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 106.2519989 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 112.81300354 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 117.31300354 74.12200165 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 143.70700073 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 148.20700073 74.12200165 Tm [(similar)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 176.4019928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 180.9019928 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 189.977005 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 194.477005 74.12200165 Tm [(Sacc)-1(ha)1(romy)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ce)-1(s)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 13.78600025 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 18.2859993 89.72200012 Tm [(ce)-1(revisiae)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 60.20999908 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 64.70999908 89.72200012 Tm [(Cdc)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 81.00099945 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 85.50099945 89.72200012 Tm [(42)-1(,)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 98.22299957 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 102.72299957 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 119 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 123.5 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 130.06100464 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 134.56100464 89.72200012 Tm [(ab)1(l)-1(e)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 152.78500366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 157.28500366 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 166.36000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 170.86000061 89.72200012 Tm [(compleme)-1(nt)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 225.21600342 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 229.71600342 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 243.71699524 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ye)-1(a)1(st)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 22.36400032 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 26.86400032 105.3219986 Tm [(cdc)-1(42-1)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 61.37400055 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 65.87400055 105.3219986 Tm [(mutant)1(.)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 99.2460022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 103.7460022 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 119.5530014 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 124.0530014 105.3219986 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 158.12800598 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 162.62800598 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 171.47000122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 175.97000122 105.3219986 Tm [(oncogene)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 218.98800659 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 223.48800659 105.3219986 Tm [(Db)1(l)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 238.48699951 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 16.24699974 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 20.74699974 120.92199707 Tm [(repor)1(ted)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 58.4129982 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 62.9129982 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 71.98799896 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 76.48799896 120.92199707 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 122.97299957 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 127.47299957 120.92199707 Tm [(cata)1(l)-1(yze)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 161.97900391 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 166.47900391 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 180.47999573 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 184.97999573 120.92199707 Tm [(disso)1(c)-1(iat)1(ion)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 236.08399963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 240.58399963 120.92199707 Tm [(o)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(f)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 3.11999989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 7.61999989 136.52200317 Tm [(GD)1(P)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 26.67499924 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 31.17499924 136.52200317 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 51.88600159 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 56.38600159 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 71.84200287 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 76.34200287 136.52200317 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 109.81500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 114.31500244 136.52200317 Tm [(This)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 131.57699585 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 136.07699585 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 167.38400269 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 171.88400269 136.52200317 Tm [(coul)-1(d)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 195.81700134 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 200.31700134 136.52200317 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 235.99200439 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 240.49200439 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ctin)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 15.80700016 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 20.30699921 152.12199402 Tm [(po)1(l)-1(ymerizat)1(ion)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 84.72200012 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 89.22200012 152.12199402 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 124.1190033 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 128.6190033 152.12199402 Tm [(its)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 138.53300476 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 143.03300476 152.12199402 Tm [(direct)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 167.59399414 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 172.09399414 152.12199402 Tm [(binding)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 205.23800659 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 209.73800659 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 218.81300354 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 223.31300354 152.12199402 Tm [(Neu)-1(r)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(al)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 7.36999989 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 11.86999989 167.72200012 Tm [(Wiskot)1(t-)1(Aldrich)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 79.18099976 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 83.68099976 167.72200012 Tm [(syndrome)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 126.61100006 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 131.11099243 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 162.41799927 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 166.91799927 167.72200012 Tm [(\(N-W)1(ASP\),)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 212.4980011 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 216.9980011 167.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 242.09500122 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.1499939 0.75 m 167.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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