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[<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(DUSP22)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.83899689 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.33900452 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 170.58900452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P2)1(2)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 117.82299805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 120.1969986 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 145.84700012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 148.22099304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 191.77999878 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 194.15400696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 231.94999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VHX;)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 83.75900269 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 86.13300323 12.82499981 Tm [(JK)1(AP;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 109.24500275 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 111.6190033 12.82499981 Tm [(JSP1;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 133.34700012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 135.72099304 12.82499981 Tm [(MKP)1(X;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 163.83700562 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 166.21099854 12.82499981 Tm [(JSP-1;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 191.15400696 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 193.52799988 12.82499981 Tm [(MKP)1(-x;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 223.95599365 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 226.33000183 12.82499981 Tm [(LMWDS)-1(P)1(2;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 273.90301514 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 276.27700806 12.82499981 Tm [(LMW-DS)-1(P2)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 324.25500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 336 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DUSP22)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 97.08899689 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 83 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 164.5249939 172.3500061 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2749939 -0.25 l 259.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Mito)1(gen)-1(-)1(ac)-1(t)1(ivat)1(e)-1(d)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 79.71700287 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 84.21700287 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 115.52400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 120.02400208 11.72200012 Tm [(\(MAP)1(\))] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 146.66799927 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 151.16799927 11.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 182.42199707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 186.92199707 11.72200012 Tm [(are)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 200.44000244 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 204.94000244 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 209.91499329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 214.41499329 11.72200012 Tm [(larg)1(e)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 236.08399963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 240.58399963 11.72200012 Tm [(cl)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ass)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 13.30700016 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 17.80699921 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 26.64900017 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 31.14900017 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 66.62200165 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 71.12200165 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 107.49099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 111.99099731 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 119.93199921 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 124.43199921 27.3220005 Tm [(signal)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 149.66499329 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 154.16499329 27.3220005 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 208.4730072 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 212.9730072 27.3220005 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 25.88800049 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 30.38800049 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 43.90599823 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 48.40599823 42.92200089 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 87.55699921 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 92.05699921 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 102.56900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 107.06900024 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 112.04399872 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 116.54399872 42.92200089 Tm [(rang)1(e)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 141.36399841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 145.86399841 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 154.70599365 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 159.20599365 42.92200089 Tm [(st)1(i)-1(muli)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 187.88900757 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 192.38900757 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 208.66600037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 213.16600037 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 248.29100037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 4.9749999 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 9.47500038 58.52199936 Tm [(number)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 43.29100037 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 47.79100037 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 56.63299942 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 61.13299942 58.52199936 Tm [(ph)1(y)-1(sio)1(l)-1(o)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 117.62000275 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 122.12000275 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 138.39700317 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 142.89700317 58.52199936 Tm [(pa)1(tho)1(l)-1(o)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 196.38699341 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 200.88699341 58.52199936 Tm [(changes)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 236.49099731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 240.99099731 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 248.93200684 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 14.0010004 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 18.50099945 74.12200165 Tm [(ce)-1(ll.)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 35.07699966 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 39.57699966 74.12200165 Tm [(Dual)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 59.34799957 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 63.84799957 74.12200165 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 106.31700134 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 110.81700134 74.12200165 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 170.0249939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 174.5249939 74.12200165 Tm [(\(DSPs\))] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 202.25900269 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 206.75900269 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 220.2769928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 224.7769928 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 229.7519989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 234.2519989 74.12200165 Tm [(sub)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 20.21500015 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 24.71500015 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 33.55699921 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 38.05699921 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 52.05799866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 56.55799866 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 87.86499786 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 92.36499786 89.72200012 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 126.85299683 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 131.35299683 89.72200012 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 186.39500427 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 190.89500427 89.72200012 Tm [(\(PTP\))] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 213.07899475 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 217.57899475 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 239.09500122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 243.59500122 89.72200012 Tm [(s)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(uperfamily,)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 48.08499908 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 52.58499908 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 77.68199921 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 82.18199921 105.3219986 Tm [(are)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 95.69999695 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 100.19999695 105.3219986 Tm [(sele)-1(ctive)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 137.06599426 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 141.56599426 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 153.84399414 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 158.34399414 105.3219986 Tm [(deph)1(osph)1(orylating)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 240.01600647 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 244.51600647 105.3219986 Tm [(c)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ritical)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 23.46199989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 27.96199989 120.92199707 Tm [(ph)1(osph)1(oth)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 107.90299988 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 112.40299988 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 128.67999268 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 133.17999268 120.92199707 Tm [(ph)1(osph)1(otyros)1(i)-1(ne)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 205.85699463 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 210.35699463 120.92199707 Tm [(residues)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 246.03599548 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(wit)1(hin)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 26.33600044 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 30.83600044 136.52200317 Tm [(MAP)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 51.4679985 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 55.9679985 136.52200317 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 89.38800049 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 93.88800049 136.52200317 Tm [(DSP)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 111.44400024 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 115.94400024 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 137.46000671 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 141.96000671 136.52200317 Tm [(expression)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 187.91400146 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 192.41400146 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 198.9750061 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 203.4750061 136.52200317 Tm [(induc)-1(ed)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 238.09500122 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 242.59500122 136.52200317 Tm [(b)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(y)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 4.76399994 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 9.26399994 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 14.23900032 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 18.73900032 152.12199402 Tm [(ho)1(st)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 37.52099991 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 42.02099991 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 50.86299896 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 55.36299896 152.12199402 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 86.27899933 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 90.77899933 152.12199402 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 120.06400299 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 124.56400299 152.12199402 Tm [(and/or)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 153.84500122 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 158.34500122 152.12199402 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 189.10699463 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 193.60699463 152.12199402 Tm [(st)1(re)-1(ss)1(e)-1(s,)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 229.44000244 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 233.94000244 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(reby)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 19.05500031 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 23.55500031 167.72200012 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 67.6760025 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 72.1760025 167.72200012 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 116.44200134 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 120.94200134 167.72200012 Tm [(MAP)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 141.57400513 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 146.07400513 167.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 173.16200256 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 177.66200256 167.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 227.7460022 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 232.2460022 167.72200012 Tm [(me)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 0.75 m 164.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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