%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 130 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.31700134 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 127.99299622 23.67700005 Tm 0 Tr [(CD)-1(C42E)1(P)-1(4)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 226.54200745 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 336.98199463 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDC)-1(4)1(2E)-1(P)1(4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.9240036 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.42399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.67399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC42EP4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.90699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.28100586 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.30499268 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.23800659 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.03399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CEP4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.28099823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.65499878 12.82499981 Tm [(BORG4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.77500153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.14900208 12.82499981 Tm [(KA)1(IA17)1(77)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.68800354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(4)1(2E)-1(P)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.1740036 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700220027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 178.0249939 0.75 l 178.0249939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 179.0249939 -0.25 l 179.0249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 178.7749939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 178.7749939 141.1499939 l h f* Q q 1 0 0 1 178.3999939 0 cm -0.625 -0.25 m 245.0249939 -0.25 l 245.0249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.38199997 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.88199997 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.72399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.22399902 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.18000031 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.69599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.19599915 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.75700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.25700378 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.23199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.73199463 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.9960022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.4960022 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.33799744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.83799744 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.83900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.33900452 11.72200012 Tm [(CDC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(2-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.31499863 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.81499863 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.12200165 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.62200165 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.87000275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.37000275 27.3220005 Tm [(Members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.16000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.66000366 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.5019989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.0019989 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.45799255 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.95799255 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.03999329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.53999329 27.3220005 Tm [(int)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(eract)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.38400078 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.88400078 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.27999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.77999878 42.92200089 Tm [(Rho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.91899872 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.41899872 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.50099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.00099945 42.92200089 Tm [(GTPa)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.77200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.27200317 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.54899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.04899597 42.92200089 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.72399902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.22399902 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.2250061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.7250061 42.92200089 Tm [(org)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(aniza)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.33100128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.83100128 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.67300034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.17300034 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.1740036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.6740036 58.52199936 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.45600128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.95600128 58.52199936 Tm [(cy)-1(t)1(oske)-1(leton.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.76800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.26800537 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.52999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.02999878 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.33700562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.83700562 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.51899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.50699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.00699997 74.12200165 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08800125 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58800125 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.66300201 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.16300201 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.60900116 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.10900116 74.12200165 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.47299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.97299957 74.12200165 Tm [(CDC42)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.42500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.92500305 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.20199585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.70199585 74.12200165 Tm [(TC1)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.43699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.93699646 74.12200165 Tm [(GTPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.58200073 89.72200012 Tm [(GTP-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.86000061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.36000061 89.72200012 Tm [(manne)-1(r)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.56900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.06900024 89.72200012 Tm [(Wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.42100525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.92100525 89.72200012 Tm [(overexpressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.06399536 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 105.3219986 Tm [(fib)1(roblas)1(ts,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.83200073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.33200073 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.78800201 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.28800201 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.59500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.09500122 105.3219986 Tm [(wa)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.34199524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.84199524 105.3219986 Tm [(ab)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.06599426 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.56599426 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.64100647 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.14100647 105.3219986 Tm [(induc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.0039978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.5039978 105.3219986 Tm [(pseud)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(op)1(odia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.31800079 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.81800079 120.92199707 Tm [(fo)1(rmatio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.68599701 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.18599701 120.92199707 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.28299713 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.78299713 120.92199707 Tm [(sugg)1(e)-1(st)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.49699402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.99699402 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.97200012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.47200012 120.92199707 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.13200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.63200378 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.57299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.07299805 120.92199707 Tm [(induc)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 136.52200317 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.58499908 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.08499908 136.52200317 Tm [(filament)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.40799713 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.90799713 136.52200317 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.66100311 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.16100311 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.43800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.93800354 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.3480072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.8480072 136.52200317 Tm [(sha)1(pe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.38499451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.88499451 136.52200317 Tm [(control.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.73899841 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 178.0249939 0.75 l 178.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 179.0249939 -0.25 l 179.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 178.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 178.7749939 16.35000038 l h f* Q q 1 0 0 1 178.3999939 0 cm -0.625 -0.25 m 245.0249939 -0.25 l 245.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 178.0249939 0.75 l 178.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 179.0249939 -0.25 l 179.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 178.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 178.7749939 16.35000038 l h f* Q q 1 0 0 1 178.3999939 0 cm -0.625 -0.25 m 245.0249939 -0.25 l 245.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDC42EP4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.18500137 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 178.3999939 0.75 m 178.3999939 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 178.3999939 141.8999939 m 178.3999939 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 178.3999939 158.25 m 178.3999939 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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