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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.31700134 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 127.99299622 23.67700005 Tm 0 Tr [(CD)-1(C42E)1(P)-1(3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 226.54200745 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 336.98199463 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDC)-1(4)1(2E)-1(P)1(3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.9240036 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.42399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.67399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC42EP3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.90699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.28100586 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.30499268 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.23800659 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.03399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UB1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.58000183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.95400238 12.82499981 Tm [(CEP3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.23500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.60900116 12.82499981 Tm [(BORG2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.91999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(4)1(2E)-1(P)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.1740036 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700220027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 164.5249939 141.1499939 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2749939 -0.25 l 259.2749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.25100708 11.72200012 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.61500549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.11500549 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.19700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.69700623 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.53900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.03900146 11.72200012 Tm [(gua)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nosine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4810009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.98099899 27.3220005 Tm [(tr)1(i)-1(p)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.06600189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.56600189 27.3220005 Tm [(\(GTP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.93599701 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.43599701 27.3220005 Tm [(metab)1(olizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.68600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.18600464 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.65899658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.15899658 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.3809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.8809967 27.3220005 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(onta)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.5359993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.0359993 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.01100159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.51100159 42.92200089 Tm [(CRIB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.69900131 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.1989975 42.92200089 Tm [(\(Cdc42)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.21800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.71800232 42.92200089 Tm [(Rac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.08100128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.58100128 42.92200089 Tm [(interactive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.48399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.98399353 42.92200089 Tm [(binding\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.13299561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.63299561 42.92200089 Tm [(do)1(main.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.79000092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.29000092 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.13199997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.63199997 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.08799744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.58799744 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16999817 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.01200104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51200104 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.98500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.48500061 58.52199936 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.32600403 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.82600403 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.96699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.46699524 58.52199936 Tm [(effec)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.61099243 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.45300293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(CDC42)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.45199966 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.95199966 74.12200165 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.85900116 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.35900116 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.16600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.66600037 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.17300415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.67300415 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.97999573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.47999573 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.04100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.54100037 74.12200165 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.91000366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41000366 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.35099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.85099792 74.12200165 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29399967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79399967 89.72200012 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.44000244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.94000244 89.72200012 Tm [(re-or)1(ganizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.6230011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.1230011 89.72200012 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.55999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.05999756 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.47000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.97000122 89.72200012 Tm [(sha)1(pe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.50700378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.00700378 89.72200012 Tm [(chan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ges,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.19599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.69599915 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.54600143 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.04599762 105.3219986 Tm [(pseudop)1(odia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.68699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.18699646 105.3219986 Tm [(fo)1(rmatio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05499268 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55499268 105.3219986 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.88800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.38800049 105.3219986 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.94900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.79800034 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.29800034 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.81399918 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.31399918 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.875 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.375 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.06500244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.56500244 120.92199707 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.83300018 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.33300018 120.92199707 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.12800598 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.62800598 120.92199707 Tm [(19)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.3500061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.8500061 120.92199707 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.57299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.07299805 120.92199707 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(plicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.74900055 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.24900055 136.52200317 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.41799927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.91799927 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.85900116 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.35900116 136.52200317 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.73100281 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.23100281 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.15299988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.65299988 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.38900757 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 164.5249939 16.35000038 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2749939 -0.25 l 259.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 163.7749939 0.75 l 163.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 164.7749939 -0.25 l 164.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 164.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 164.5249939 16.35000038 l h f* Q q 1 0 0 1 164.1499939 0 cm -0.625 -0.25 m 259.2749939 -0.25 l 259.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDC42EP3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.18500137 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 0.75 m 164.1499939 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 141.8999939 m 164.1499939 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.1499939 158.25 m 164.1499939 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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