%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 152 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.9260025 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 126.60199738 23.67700005 Tm 0 Tr [(CD)-1(C42B)1(PB)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 227.93299866 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 338.37298584 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDC)-1(4)1(2BPB)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 123.89800262 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.397995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.147995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC42BP)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.8809967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.25500488 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.90499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.27900696 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.83799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.21200562 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.00799561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MRCKB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.44400024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(4)1(2BPB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14800262 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700220027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 149.5249939 0.75 l 149.5249939 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 150.5249939 -0.25 l 150.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.2749939 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 150.2749939 125.55000305 l h f* Q q 1 0 0 1 149.8999939 0 cm -0.625 -0.25 m 273.5249939 -0.25 l 273.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.6309967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.1309967 11.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.63499832 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.13499832 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.38300323 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88300323 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.69000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.19000244 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.69700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.19700623 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.5039978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.0039978 27.3220005 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.21899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.71899414 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.69400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.19400024 27.3220005 Tm [(Cdc42)-1(/)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(Rac-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.40000153 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.90000153 42.92200089 Tm [(p21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.20400238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.70400238 42.92200089 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.84799957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.34799957 42.92200089 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.17500305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.67500305 42.92200089 Tm [(resem)-1(b)1(lin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.76400757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.26400757 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.48599243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.98599243 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.82800293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.32800293 42.92200089 Tm [(PA)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ki)-1(na)1(se)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.25399971 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.75400162 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.56100082 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.06100082 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.14900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.64900208 58.52199936 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.47599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.97599792 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.81799316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.31799316 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.27400208 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.58099365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.08099365 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.64199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.14199829 58.52199936 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.81599426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.31599426 58.52199936 Tm [(cl)-1(o)1(se)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.37701416 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.12899971 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.62900162 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.70399857 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.20399857 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.4260025 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.9260025 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.76799774 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.26799774 74.12200165 Tm [(myoto)1(n)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.71499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.21499634 74.12200165 Tm [(dyst)1(roph)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.46600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.96600342 74.12200165 Tm [(ki)-1(na)1(se)-1(-)1(re)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.07600403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.57600403 74.12200165 Tm [(ROK.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.66500854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(Studies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.51799965 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01800156 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.86000061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.36000061 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.36100006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.86100006 89.72200012 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.05599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.55599976 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.0719986 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.5719986 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.51300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.01300049 89.72200012 Tm [(rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.7769928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.2769928 89.72200012 Tm [(sugg)1(e)-1(st)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.99099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.49099731 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.71299744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.21299744 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.66900635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.16900635 89.72200012 Tm [(ki)-1(na)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.94300079 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.44300079 105.3219986 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.2840004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.7840004 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.92499924 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.42500305 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.40000153 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.90000153 105.3219986 Tm [(do)1(wnstr)1(e)-1(am)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.5 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135 105.3219986 Tm [(effec)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.47799683 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.97799683 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82000732 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.32000732 105.3219986 Tm [(Cdc42)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.16600037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.66600037 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.60699463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.10699463 105.3219986 Tm [(cy)-1(t)1(oske)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(etal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.82900047 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.32900047 120.92199707 Tm [(reorg)1(ani)-1(z)1(at)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.28500366 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 149.5249939 0.75 l 149.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.5249939 -0.25 l 150.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 150.2749939 16.35000038 l h f* Q q 1 0 0 1 149.8999939 0 cm -0.625 -0.25 m 273.5249939 -0.25 l 273.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 149.5249939 0.75 l 149.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.5249939 -0.25 l 150.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 150.2749939 16.35000038 l h f* Q q 1 0 0 1 149.8999939 0 cm -0.625 -0.25 m 273.5249939 -0.25 l 273.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDC42B)-1(PB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.2519989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 149.5249939 0.75 l 149.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.5249939 -0.25 l 150.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 150.2749939 16.35000038 l h f* Q q 1 0 0 1 149.8999939 0 cm -0.625 -0.25 m 273.5249939 -0.25 l 273.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.35400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.85400009 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.06800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.56800079 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3500061 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56100464 11.72200012 Tm [(internal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.31300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.81300354 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.65499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.15499878 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.69599915 11.72200012 Tm [(MRC)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.8999939 0.75 m 149.8999939 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.8999939 126.30000305 m 149.8999939 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.8999939 142.65000916 m 149.8999939 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.8999939 159.00001526 m 149.8999939 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>