%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 157 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.52200317 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 138.19799805 23.67700005 Tm 0 Tr [(DUSP12)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.33700562 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.77700806 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(DUSP12)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.83899689 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.33900452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.83900452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P1)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.82299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.1969986 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.84700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.22099304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.77999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.15400696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.94999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(YV)-1(H1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.93199921 12.82499981 Tm [(DUSP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.6989975 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DUSP12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.08899689 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 169.0249939 0.75 l 169.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 170.0249939 -0.25 l 170.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 169.7749939 172.3500061 l h f* Q q 1 0 0 1 169.3999939 0 cm -0.625 -0.25 m 254.0249939 -0.25 l 254.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.77799988 27.3220005 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.24700165 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.74700165 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.05400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.55400085 27.3220005 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.59599304 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.09599304 27.3220005 Tm [(subf)1(amily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.80400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.30400085 27.3220005 Tm [(Thes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.81400299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.31400299 42.92200089 Tm [(inac)-1(t)1(ivat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.64900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.14900208 42.92200089 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.98199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.48199463 42.92200089 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.46200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.96200562 42.92200089 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.21600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.71600342 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.22799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.72799683 42.92200089 Tm [(dep)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ho)1(spho)1(ry)-1(la)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.06099701 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.56099701 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.92500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.42500305 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.4260025 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9260025 58.52199936 Tm [(ph)1(osph)1(oserin)-1(e/thr)1(e)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.46800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.96800232 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.24499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ph)1(osph)1(otyros)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.17700195 74.12200165 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.02300262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.52300262 74.12200165 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.09399414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.59399414 74.12200165 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.71499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.21499634 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.88999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.38999939 74.12200165 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(embers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.99699974 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.49700165 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.3390007 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.8390007 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.84000015 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.33999634 89.72200012 Tm [(mito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.69599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.19599915 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.50300598 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.00300598 89.72200012 Tm [(\(MAP)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.64700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.14700317 89.72200012 Tm [(ki)-1(na)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.68999863 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.19000244 105.3219986 Tm [(\(MAP)1(K/ERK,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.08899689 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.58899689 105.3219986 Tm [(SAPK)1(/)-1(JNK)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.94099426 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.44099426 105.3219986 Tm [(p38)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.91700745 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.41700745 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.51400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.01400757 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.57499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.07499695 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ssociat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.15299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.65299988 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.04899979 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.5490036 120.92199707 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.31099701 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.81099701 120.92199707 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.16099548 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.66099548 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.93800354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.43800354 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.92999268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.03900146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.53900146 136.52200317 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.96900177 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.46900177 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.31099701 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.81099701 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.81199646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.31199646 136.52200317 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.39399719 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.89399719 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.73599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.23599243 136.52200317 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.90800476 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.40800476 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.8769989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.3769989 136.52200317 Tm [(ph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(osp)1(hat)1(ases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.91799927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.41799927 152.12199402 Tm [(sho)1(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.95300293 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.45300293 152.12199402 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.93099976 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.43099976 152.12199402 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.28100586 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.78100586 152.12199402 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.15400696 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.65400696 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.93200684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.43200684 152.12199402 Tm [(var)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ious)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.82900047 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.32900047 167.72200012 Tm [(MAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.96099854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.46099854 167.72200012 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.8809967 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.3809967 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.32099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.82099915 167.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.55299377 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.05299377 167.72200012 Tm [(dist)1(ributio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.86500549 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.36500549 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.64199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.14199829 167.72200012 Tm [(su)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 169.3999939 0.75 m 169.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>