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g [<0009000A000B000C>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.18499756 12.82499981 Tm [(CDC)-1(4)1(0)] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 115.11100006 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.61099243 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 178.11099243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC40)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 112.03399658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 114.40799713 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 140.05799866 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 142.43200684 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 185.99099731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 188.36500549 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 226.16099548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000B>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(EHB3;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 67.51200104 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 69.88600159 12.82499981 Tm [(PRP)1(17;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 99.88899994 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 102.26300049 12.82499981 Tm [(PRP)1(F)-1(1)1(7)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 134.28100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0018>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(4)1(0)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 70.3010025 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001A>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 69.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B001C001D001E>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F00200021000E>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00220004>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 82 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 93 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700210026>] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 99 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 100 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 101 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 102 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 104 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 154.7749939 156.75 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 105 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pre-mR)1(NA)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 45.90100098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 50.40100098 11.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 83.31600189 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 87.81600189 11.72200012 Tm [(occ)-1(urs)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 115.71199799 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 120.21199799 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 128.15299988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 132.65299988 11.72200012 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 148.83399963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 153.33399963 11.72200012 Tm [(seque)-1(nt)1(ial)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 197.67900085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 202.17900085 11.72200012 Tm [(tr)1(anse)-1(st)1(erific)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(at)1(ion)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 21.98999977 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 26.48999977 27.3220005 Tm [(st)1(e)-1(ps)1(.)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 51.19599915 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 55.69599915 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 71.50299835 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 76.00299835 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 107.30999756 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 111.80999756 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 149.31700134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 153.81700134 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 164.32899475 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 168.82899475 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 184.28500366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 188.78500366 27.3220005 Tm [(gene)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 210.30099487 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 214.80099487 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 221.36199951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 225.86199951 27.3220005 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 251.55200195 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 256.05200195 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(o)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 5.72200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 10.22200012 42.92200089 Tm [(be)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 21.07600021 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 25.57600021 42.92200089 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 62.7840004 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 67.28399658 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 79.56199646 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 84.06199646 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 98.06300354 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 102.56300354 42.92200089 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 137.79800415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 142.29800415 42.92200089 Tm [(st)1(e)-1(p)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 160.67199707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 165.17199707 42.92200089 Tm [(II)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 170.46299744 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 174.96299744 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 182.90400696 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 187.40400696 42.92200089 Tm [(pre-mR)1(NA)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 233.54699707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 238.04699707 42.92200089 Tm [(splici)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ng)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 11.30300045 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 15.80300045 58.52199936 Tm [(pro)1(c)-1(ess.)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 50.82699966 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 55.32699966 58.52199936 Tm [(It)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 61.32600021 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 65.8259964 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 72.38700104 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 76.88700104 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 102.57700348 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 107.07700348 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 115.01799774 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 119.51799774 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 133.51899719 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 138.01899719 58.52199936 Tm [(splice)-1(o)1(some,)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 193.65800476 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 198.15800476 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 214.43499756 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 218.93499756 58.52199936 Tm [(contains)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 255.1499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(seve)-1(n)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 24.64900017 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 29.14900017 74.12200165 Tm [(WD)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 45.1629982 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 49.6629982 74.12200165 Tm [(repeats)1(,)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 83.72100067 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 88.22100067 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 113.31800079 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 117.81800079 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 153.55900574 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 158.05900574 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 166 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 170.5 74.12200165 Tm [(pro)1(tein)-1(-)1(pro)1(tein)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 237.00700378 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 241.50700378 74.12200165 Tm [(inte)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ractio)1(n)-1(s.)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 36.27199936 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 40.77199936 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 58.0340004 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 62.5340004 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 93.84100342 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 98.34100342 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 113.02300262 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 117.52300262 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 122.4980011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 126.9980011 89.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 167.84500122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 172.34500122 89.72200012 Tm [(similarit)1(y)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 211.05200195 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 215.55200195 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 224.6269989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 229.1269989 89.72200012 Tm [(ye)-1(a)1(st)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 251.49099731 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(Prp)1(1)-1(7)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 25.24699974 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 29.74699974 105.3219986 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 63.22000122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 67.72000122 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 92.81700134 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 97.31700134 105.3219986 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 137.22399902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 141.72399902 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 149.66499329 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 154.16499329 105.3219986 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 170.34599304 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 174.84599304 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 211.78599548 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 216.28599548 105.3219986 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 247.04800415 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 251.54800415 105.3219986 Tm [(pr)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(oce)-1(s)1(se)-1(s:)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 35.11199951 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 39.61199951 120.92199707 Tm [(pre-mR)1(NA)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 85.75499725 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 90.25499725 120.92199707 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 123.16999817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 127.66999817 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 143.94700623 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 148.44700623 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 162.85699463 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 167.35699463 120.92199707 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 188.64900208 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 193.14900208 120.92199707 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 246.51600647 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 251.01600647 120.92199707 Tm [(It)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 257.01501465 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(sugg)1(e)-1(st)1(s)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 38.01699829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 42.51699829 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 59.73899841 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 64.23899841 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 79.69499969 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 84.19499969 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 115.5019989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 120.0019989 136.52200317 Tm [(may)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 138.17300415 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 142.67300415 136.52200317 Tm [(play)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 160.55400085 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 165.05400085 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 170.02900696 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 174.52900696 136.52200317 Tm [(role)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 191.18899536 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 195.68899536 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 203.63000488 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 208.13000488 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 222.53999329 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 227.03999329 136.52200317 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 248.33200073 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 252.83200073 136.52200317 Tm [(p)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(rog)1(ression.)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 47.61899948 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 271 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 272 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 273 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 0.75 m 154.3999939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 157.5 m 154.3999939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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