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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.52200317 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 138.19799805 23.67700005 Tm 0 Tr [(DUSP10)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.33700562 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.77700806 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(DUSP10)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.83899689 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.33900452 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 181.08900452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P1)1(0)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 117.82299805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 120.1969986 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 145.84700012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 148.22099304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 191.77999878 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 194.15400696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 231.94999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(MKP)1(5;)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 69.98799896 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 72.36199951 12.82499981 Tm [(MKP)1(-5)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 100.75499725 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DUSP10)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 97.08899689 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 71 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 169.7749939 0.75 l 169.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 170.7749939 -0.25 l 170.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 170.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 170.5249939 172.3500061 l h f* Q q 1 0 0 1 170.1499939 0 cm -0.625 -0.25 m 253.2749939 -0.25 l 253.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Dual)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 19.77099991 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 24.27099991 11.72200012 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 66.73999786 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 71.23999786 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 102.54699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 107.04699707 11.72200012 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 166.25500488 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 170.75500488 11.72200012 Tm [(inac)-1(t)1(ivat)1(e)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 212.08999634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 216.58999634 11.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 236.42300415 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 240.92300415 11.72200012 Tm [(t)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(arg)1(e)-1(t)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 22.62700081 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 27.12700081 27.3220005 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 58.38100052 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 62.88100052 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 73.39299774 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 77.89299774 27.3220005 Tm [(deph)1(osph)1(orylating)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 159.56500244 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 164.06500244 27.3220005 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 184.42900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 188.92900085 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 202.92999268 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 207.42999268 27.3220005 Tm [(ph)1(osph)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(oserine)-1(/t)1(hreonin)-1(e)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 77.0759964 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 81.5759964 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 97.85299683 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 102.35299683 42.92200089 Tm [(ph)1(osph)1(otyros)1(i)-1(ne)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 175.02999878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 179.52999878 42.92200089 Tm [(residues.)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 217.37600708 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 221.87600708 42.92200089 Tm [(They)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 242.44700623 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 44.12099838 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 48.62099838 58.52199936 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 84.29599762 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 88.79599762 58.52199936 Tm [(members)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 129.22599792 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 133.72599792 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 142.56799316 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 147.06799316 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 161.06900024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 165.56900024 58.52199936 Tm [(MAP)1(K)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 191.91400146 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 196.41400146 58.52199936 Tm [(superfa)1(mi)-1(l)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(y)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 4.76399994 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 9.26399994 74.12200165 Tm [(\(MAP)1(K/ERK,)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 61.1629982 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 65.66300201 74.12200165 Tm [(SAPK)1(/)-1(JNK)1(,)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 111.01499939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 115.51499939 74.12200165 Tm [(p38)-1(\),)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 136.99099731 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 141.49099731 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 166.58799744 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 171.08799744 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 177.64900208 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 182.14900208 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 227.27600098 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 231.77600098 74.12200165 Tm [(wit)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(h)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 5.54199982 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 10.04199982 89.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 40.80400085 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 45.30400085 89.72200012 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 98.65399933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 103.15399933 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 119.43099976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 123.93099976 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 187.42300415 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 191.92300415 89.72200012 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 229.96200562 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 234.46200562 89.72200012 Tm [(m)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(embers)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 31.99699974 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 36.49700165 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 45.3390007 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 49.8390007 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 65.29499817 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 69.79499817 105.3219986 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 95.8769989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 100.3769989 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 109.21900177 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 113.71900177 105.3219986 Tm [(dual)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 132.39100647 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 136.89100647 105.3219986 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 179.36000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 183.86000061 105.3219986 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 243.06799316 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(sho)1(w)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 22.53499985 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 27.03499985 120.92199707 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 58.51300049 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 63.01300049 120.92199707 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 102.86299896 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 107.36299896 120.92199707 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 156.73599243 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 161.23599243 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 173.51400757 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 178.01400757 120.92199707 Tm [(MAP)1(Ks,)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 210.69200134 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 215.19200134 120.92199707 Tm [(dif)1(fe)-1(r)1(e)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nt)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 8.89900017 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 13.39900017 136.52200317 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 38.13100052 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 42.63100052 136.52200317 Tm [(dist)1(ributio)1(n)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 92.44300079 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 96.94300079 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 113.22000122 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 117.72000122 136.52200317 Tm [(subce)-1(llular)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 163.94200134 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 168.44200134 136.52200317 Tm [(localizat)1(ion,)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 219.41900635 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 223.91900635 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 240.19599915 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 36.93999863 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 41.43999863 152.12199402 Tm [(mod)1(e)-1(s)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 70.62400055 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 75.12400055 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 83.96600342 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 88.46600342 152.12199402 Tm [(induc)-1(ib)1(i)-1(lit)1(y)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 135.66799927 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 140.16799927 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 149.00999451 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 153.50999451 152.12199402 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 173.34300232 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 177.84300232 152.12199402 Tm [(expression)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 223.79699707 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 228.29699707 152.12199402 Tm [(by)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 238.80900574 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 52.19400024 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 56.69400024 167.72200012 Tm [(st)1(i)-1(muli.)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 87.54399872 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 92.04399872 167.72200012 Tm [(This)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 109.30599976 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 113.80599976 167.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 135.32200623 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 139.82200623 167.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 173.89700317 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 178.39700317 167.72200012 Tm [(binds)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 202.00900269 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 206.50900269 167.72200012 Tm [(to)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 215.58399963 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 220.08399963 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 236.36099243 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 240.86099243 167.72200012 Tm [(i)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 170.1499939 0.75 m 170.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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