%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 158 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.09799957 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.77400208 23.67700005 Tm 0 Tr [(DUSP8)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.76199341 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 321.20199585 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(DUSP8)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.01699829 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.51699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.26699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.50099945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.875 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.5249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.89900208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45799255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.83200073 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.62800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HB5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.38500214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.75900269 12.82499981 Tm [(HVH8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.93199921 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.30599976 12.82499981 Tm [(HVH-)-1(5)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.69299316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.06700134 12.82499981 Tm [(C11orf81)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.35499573 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DUSP8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 157.0249939 0.75 l 157.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 158.0249939 -0.25 l 158.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 157.7749939 172.3500061 l h f* Q q 1 0 0 1 157.3999939 0 cm -0.625 -0.25 m 266.0249939 -0.25 l 266.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.67200089 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.17200089 27.3220005 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.64099884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.14099884 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.44799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.94799805 27.3220005 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.99000549 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.49000549 27.3220005 Tm [(subf)1(amily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.19799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.69799805 27.3220005 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.77799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.27799988 27.3220005 Tm [(ph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(osp)1(hat)1(ases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.91799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.41799927 42.92200089 Tm [(inac)-1(t)1(ivat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.75299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.25299835 42.92200089 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.08599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.58599854 42.92200089 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.56599426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.06599426 42.92200089 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.32000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.82000732 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.33200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.83200073 42.92200089 Tm [(deph)1(osph)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ylating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.18400002 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.68399811 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.04800034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.54800034 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.5490036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.0490036 58.52199936 Tm [(ph)1(osph)1(oserin)-1(e/thr)1(e)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.59100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.09100342 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.36799622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.86799622 58.52199936 Tm [(ph)1(osph)1(ot)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(yrosine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.13500023 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.63499832 74.12200165 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.48100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.98100281 74.12200165 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.55200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.05200195 74.12200165 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.17300415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.67300415 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.3480072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.8480072 74.12200165 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.27799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.77799988 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.61999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11999512 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 89.72200012 Tm [(mito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5039978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.0039978 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.31100464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.81100464 89.72200012 Tm [(\(MAP)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.45500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.95500183 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.04299927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.54299927 89.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.6269989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.1269989 89.72200012 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(MAP)1(K/ERK,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.89400101 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.39400101 105.3219986 Tm [(SAPK)1(/)-1(JNK)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.7460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.2460022 105.3219986 Tm [(p38)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.22200012 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.31900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.81900024 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.38000488 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.88000488 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.00700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.50700378 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.90299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.40299988 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.35199928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.85199928 120.92199707 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.20200348 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.70200348 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.97899628 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.47899628 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.97099304 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.47099304 120.92199707 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.50999451 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.00999451 120.92199707 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.44000244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 136.52200317 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.92499924 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.42499924 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.26699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.76699829 136.52200317 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.43900299 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.93900299 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.40800476 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.90800476 136.52200317 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.11599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.61599731 136.52200317 Tm [(sho)1(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.15100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.65100098 136.52200317 Tm [(dist)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.4119997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.91200066 152.12199402 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.76200104 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.26200104 152.12199402 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.63500214 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.13500214 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.41299438 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.91299438 152.12199402 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.8769989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.3769989 152.12199402 Tm [(MAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.00900269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.50900269 152.12199402 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.92900085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.42900085 152.12199402 Tm [(dif)1(fe)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(en)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.00500011 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50499916 167.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.23699951 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.73699951 167.72200012 Tm [(dist)1(ributio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.5490036 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.0490036 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.3259964 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.8259964 167.72200012 Tm [(subce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.04800415 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.54800415 167.72200012 Tm [(localizat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.5249939 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.0249939 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.30200195 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.80200195 167.72200012 Tm [(d)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.3999939 0.75 m 157.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>