%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 160 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.29000092 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 138.96600342 23.67700005 Tm 0 Tr [(CD)-1(C25C)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 215.56900024 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.00900269 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CDC)-1(2)1(5C)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 123.14900208 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.64900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.64900208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC25C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.63300323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.00700378 12.82499981 Tm [(\(Ab-216\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.14700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.52099609 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.17100525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.54499817 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.10400391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.47799683 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.27398682 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(2)1(5M1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.40899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.78299713 12.82499981 Tm [(MPIP)1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.38600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.75999451 12.82499981 Tm [(CDC)-1(2)1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.86999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.2440033 12.82499981 Tm [(PP)1(P1R6)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.18299866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(2)1(5C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.89900208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 175.7749939 0.75 l 175.7749939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 176.7749939 -0.25 l 176.7749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.5249939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 176.5249939 156.75 l h f* Q q 1 0 0 1 176.1499939 0 cm -0.625 -0.25 m 247.2749939 -0.25 l 247.2749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cdc)-1(25C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.35899925 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.85900116 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.41999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.91999817 11.72200012 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.31400299 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.81400299 11.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.89099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.39099884 11.72200012 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.82800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.32800293 11.72200012 Tm [(evolution)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.83700562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.33700562 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.11399841 11.72200012 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.86199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.04700089 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.54700089 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.52199936 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.02199936 27.3220005 Tm [(ke)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.79199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.29199982 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.95200348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.45200348 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.39299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.89299774 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.89399719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.39399719 27.3220005 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.625 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.125 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.96699524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.46699524 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.8769989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.3769989 27.3220005 Tm [(division.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.64300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.14300537 27.3220005 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.11299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61299896 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41999817 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.98100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.48100281 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.45600128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.95600128 42.92200089 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.44400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.94400024 42.92200089 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.98599243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.48599243 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.76300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.26300049 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(longs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.58499908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.08499908 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.15999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.65999985 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.6609993 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.1609993 58.52199936 Tm [(Cdc25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.00700378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.50700378 58.52199936 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.54899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.04899597 58.52199936 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.29699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.79699707 58.52199936 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.79600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.29600525 58.52199936 Tm [(directs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.022995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.522995 58.52199936 Tm [(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.77400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.27400208 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.11599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.61599731 74.12200165 Tm [(cy)-1(clin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.74199677 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.24199677 74.12200165 Tm [(B-bo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.10099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.60099792 74.12200165 Tm [(CDC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.7749939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.2749939 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.55200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.05200195 74.12200165 Tm [(tr)1(i)-1(g)1(ger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(en)-1(t)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.87199974 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.37200165 89.72200012 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.38800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.88800049 89.72200012 Tm [(mito)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.68399811 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.18399811 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.18299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.68299866 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.2440033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.7440033 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.00100708 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.50100708 89.72200012 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.31399536 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.81399536 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.88900757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.38900757 89.72200012 Tm [(supp)1(re)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.47200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.97200012 89.72200012 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(53)-1(-)1(i)-1(nd)1(u)-1(ce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.56900024 105.3219986 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.48500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.98500061 105.3219986 Tm [(arr)1(e)-1(st)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.625 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.125 105.3219986 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.85699463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.35699463 105.3219986 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.88000488 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.38000488 105.3219986 Tm [(splic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.28499985 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.78499985 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.35500336 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.85500336 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.6969986 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.1969986 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.65299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.15299988 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.66900635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.16900635 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.51600647 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.01600647 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.522995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.022995 120.92199707 Tm [(descri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(bed,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.77799988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.27799988 136.52200317 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.18700027 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.68699646 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.68800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.18800354 136.52200317 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.23599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.73599243 136.52200317 Tm [(nature)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.69799805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.19799805 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.03999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.53999329 136.52200317 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.25700378 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.75700378 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.59899902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.09899902 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.43299961 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.93299961 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.49399948 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.99399948 152.12199402 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61500168 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11500168 152.12199402 Tm [(kn)-1(o)1(wn.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.10099792 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 175.7749939 0.75 l 175.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.7749939 -0.25 l 176.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 176.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 176.5249939 16.35000038 l h f* Q q 1 0 0 1 176.1499939 0 cm -0.625 -0.25 m 247.2749939 -0.25 l 247.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.1499939 0.75 m 176.1499939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.1499939 157.5 m 176.1499939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>