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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 72.58000183 23.67700005 Tm 0 g [(ATXN7)1(L3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.01600647 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 166.01600647 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 342.72000122 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(ATXN)1(7L)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.47799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.72799683 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 190.72799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATXN)1(7L)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.47799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.85199738 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.40800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.78199768 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2559967 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ataxi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.05000305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.4240036 12.82499981 Tm [(7-li)-1(ke)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.77700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.15100098 12.82499981 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.47299957 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(148-3)1(47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(ATXN)1(7L)-1(3)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 348.7869873 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(at)1(axin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.80500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.30500031 11.72200012 Tm [(7-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.27299881 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.77299881 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.0510025 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q14)-1(CW)1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.34700012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(13)-1(59)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 157.125 31.95000076 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 125.55000305 l 157.125 125.55000305 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Comp)1(one)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.69599915 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.53800201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.03800201 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.03900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.53900146 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.1230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.6230011 11.72200012 Tm [(regulat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.11300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.61300659 11.72200012 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.44299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.94299316 11.72200012 Tm [(ace)-1(t)1(yl)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.01600075 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 27.3220005 Tm [(\(HAT\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97999954 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.47999954 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.95899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.45899963 27.3220005 Tm [(SAG)1(A,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.1780014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.6780014 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.65299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.15299988 27.3220005 Tm [(multipro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.58200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.08200073 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.56100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.06100464 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.28300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.78300476 27.3220005 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tiva)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.0720005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.5719986 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.15599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.65599823 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.16799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.66799927 42.92200089 Tm [(remodeling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.32200623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.82200623 42.92200089 Tm [(chromat)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.73699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.23699951 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.51400757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.01400757 42.92200089 Tm [(mediat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 58.52199936 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.02799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.52799988 58.52199936 Tm [(ace)-1(t)1(yl)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.62400055 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.12400055 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90100098 58.52199936 Tm [(deubiquitinat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.602005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.102005 58.52199936 Tm [(Wit)1(hin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.49099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.99099731 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.99200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.49200439 58.52199936 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(AG)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.3579998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.8579998 74.12200165 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.50400162 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.0039978 74.12200165 Tm [(pa)1(rticipat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.16799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.66799927 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.60899353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.10899353 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.08399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.58399963 74.12200165 Tm [(subcomplex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.522995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.022995 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.24499512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.74499512 74.12200165 Tm [(speci)-1(f)1(ic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.15899992 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.6590004 89.72200012 Tm [(deubiquitinat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8030014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.3030014 89.72200012 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.66699982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.16699982 89.72200012 Tm [(hist)1(one)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.16299438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.66299438 89.72200012 Tm [(H2)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.23399353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.73399353 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.01100159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.51100159 89.72200012 Tm [(H2)-1(B.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.56300354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.06300354 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.86999512 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.36999512 89.72200012 Tm [(SAG)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.92199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.47900009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97900009 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.54000092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.04000092 105.3219986 Tm [(rec)-1(ruit)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69000244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.19000244 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.26499939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.76499939 105.3219986 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.22200012 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.73800659 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.23800659 105.3219986 Tm [(pro)1(moters)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.36099243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.86099243 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.3730011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.8730011 105.3219986 Tm [(activa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(to)1(rs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.67700005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.17700005 120.92199707 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.94400024 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.44400024 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.58499908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.08499908 120.92199707 Tm [(MYC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.49700165 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.99700165 120.92199707 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.29399872 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.79399872 120.92199707 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.54199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.04199982 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.60299683 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.10299683 120.92199707 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.64399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.14399719 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.42199707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.92199707 120.92199707 Tm [(tr)1(ansc)-1(rip)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.67300415 120.92199707 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 239.25 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 0.75 m 156.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 17.10000038 m 156.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 33.45000076 m 156.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 49.80000305 m 156.75 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 81.75 m 156.75 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 98.09999847 m 156.75 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 114.44999695 m 156.75 239.25 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 239.25 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 239.625 m 426.92498779 239.625 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
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