%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.09799957 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.77400208 23.67700005 Tm 0 Tr [(DUSP7)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.76199341 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 321.20199585 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(DUSP7)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.01699829 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.51699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.50099945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.875 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.5249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.89900208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45799255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.83200073 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.62800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(du)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.84600067 12.82499981 Tm [(sp)-1(e)1(cif)-1(icity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.27700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.65100098 12.82499981 Tm [(ph)-1(osp)-1(hatase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.26800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.64199829 12.82499981 Tm [(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.772995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.14700317 12.82499981 Tm [(MKP)1(X;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.26300049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.63699341 12.82499981 Tm [(PYST)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.44099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DUSP7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 162.2749939 172.3500061 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Dual-)1(spec)-1(ificity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.13300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.63300323 11.72200012 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84100342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.34100342 11.72200012 Tm [(\(DU)1(SPs\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.79400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.29400635 11.72200012 Tm [(constitut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.34700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.84700012 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.82200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.32200623 11.72200012 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.99099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(heterog)1(e)-1(neous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71499634 27.3220005 Tm [(subg)1(roup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.38400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.88400269 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.72599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.22599792 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.227005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.727005 27.3220005 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.19799805 27.3220005 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.84399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.34399414 27.3220005 Tm [(cy)-1(st)1(e)-1(ine-ba)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.93899536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.43899536 27.3220005 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(rot)1(e)-1(in-)1(tyrosine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.93999863 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.44000244 42.92200089 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.48200226 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.98200226 42.92200089 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.23300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.73300171 42.92200089 Tm [(DU)1(SPs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.17399597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.67399597 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.19200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.69200134 42.92200089 Tm [(cha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(racterized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.50400162 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.00400162 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.51599884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.01599884 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.84899902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.34899902 58.52199936 Tm [(ab)1(i)-1(lit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.3730011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.8730011 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.94799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.44799805 58.52199936 Tm [(deph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.52900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.02900696 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.39300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.89300537 58.52199936 Tm [(tyro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(sine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.99000168 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.49000168 74.12200165 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.84400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.34400177 74.12200165 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.19000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.69000244 74.12200165 Tm [(DU)1(SP7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.24299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.74299622 74.12200165 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.18299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.68299866 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.75799561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.25799561 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.23300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.21500015 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.71500015 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.55699921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.05699921 89.72200012 Tm [(DU)1(SPs,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.66500092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.16500092 89.72200012 Tm [(designat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.08300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.58300018 89.72200012 Tm [(MKPs,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.92799377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.42799377 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.6499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.1499939 89.72200012 Tm [(deph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.23100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(MAP)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.34499931 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.84499931 105.3219986 Tm [(\(mito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.20700073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.70700073 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.01400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.51400757 105.3219986 Tm [(ki)-1(na)1(se)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.60800171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.10800171 105.3219986 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.58099365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.08099365 105.3219986 Tm [(ERK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.61799622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.11799622 105.3219986 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(see)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.37899971 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.87899971 120.92199707 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.11100006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61100006 120.92199707 Tm [(60)-1(17)-1(95)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.44999695 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.94999695 120.92199707 Tm [(JNK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.54399872 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.04399872 120.92199707 Tm [(\(see)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.42900085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.92900085 120.92199707 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.16099548 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.66099548 120.92199707 Tm [(60)-1(11)-1(58)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.5 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.2769928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.7769928 120.92199707 Tm [(p38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.08099365 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.58099365 120.92199707 Tm [(\(see)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.96600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.23200035 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.73200035 136.52200317 Tm [(60)-1(02)-1(89)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.40499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.90499878 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.3010025 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.8010025 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.27000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.77000427 136.52200317 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.2480011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.7480011 136.52200317 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.45899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.95899963 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.18099976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.68099976 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.522995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.022995 136.52200317 Tm [(indivi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.67200089 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.17200089 152.12199402 Tm [(MKP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18500137 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.68500137 152.12199402 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.3239975 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8239975 152.12199402 Tm [(MKPs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.00299835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.50299835 152.12199402 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.55200195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.05200195 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.0269928 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.5269928 152.12199402 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.92100525 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.42100525 152.12199402 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.4980011 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.9980011 152.12199402 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.53300095 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.03300095 167.72200012 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.26799774 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.76799774 167.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.59500122 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.09500122 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.37199402 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.87199402 167.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.39300537 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.89300537 167.72200012 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.74299622 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.24299622 167.72200012 Tm [(Cdc25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.08900452 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.58900452 167.72200012 Tm [(\(se)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 0.75 m 161.8999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>