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1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CDC)-1(2)1(5B\(Pho)-1(sph)-1(o-S)-1(e)1(r353)1(\))] TJ ET EMC /P <</MCID 8 >> BDC BT 1 0 0 -1 186.54899597 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 191.79899597 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 244.29899597 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 249.54899597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC25B\(Phos)-1(pho)-1(-Ser)1(353\))] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 194.15800476 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 196.53199768 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 222.18200684 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 224.55599976 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 268.11499023 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 270.48901367 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 308.28500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(2)1(5B\(Pho)-1(sph)-1(o-S)-1(e)1(r353)1(\))] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 173.42399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110027000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <</MCID 67 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <</MCID 70 >> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 175.07499695 0.75 l 175.07499695 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 176.07499695 -0.25 l 176.07499695 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 71 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.82499695 0.75 m 422.375 0.75 l 422.375 125.55000305 l 175.82499695 125.55000305 l h f* Q q 1 0 0 1 175.44999695 0 cm -0.625 -0.25 m 247.92500305 -0.25 l 247.92500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 73 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDC25B)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 35.09899902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 39.59899902 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 46.15999985 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 50.65999985 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 55.63499832 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 60.13499832 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 96.39900208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 100.89900208 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 109.74099731 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 114.24099731 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 128.24200439 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 132.74200439 11.72200012 Tm [(CDC25)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 162.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 166.69400024 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 192.77600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 197.27600098 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 206.11799622 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 210.61799622 11.72200012 Tm [(ph)1(osp)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ha)1(tases.)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 34.44900131 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 38.94900131 27.3220005 Tm [(CDC25B)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 74.04799652 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 78.54799652 27.3220005 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 116.10800171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 120.60800171 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 134.60899353 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 139.10899353 27.3220005 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 163.23500061 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 167.73500061 27.3220005 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 214.76100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 219.26100159 27.3220005 Tm [(ki)-1(na)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(se)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 9.27200031 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 13.77200031 42.92200089 Tm [(CDC2)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 37.94599915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 42.44599915 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 52.95800018 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 57.45800018 42.92200089 Tm [(removing)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 98.57800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 103.07800293 42.92200089 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 119.25900269 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 123.75900269 42.92200089 Tm [(ph)1(osph)1(ate)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 169.66000366 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 174.16000366 42.92200089 Tm [(gr)1(oups)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 204.53500366 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 209.03500366 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 225.31199646 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 229.81199646 42.92200089 Tm [(it)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 235.55999756 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 6.56099987 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 11.06099987 58.52199936 Tm [(required)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 47.60200119 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 52.10200119 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 64.37999725 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 68.87999725 58.52199936 Tm [(en)-1(t)1(ry)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 91.08599854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 95.58599854 58.52199936 Tm [(into)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 112.60199738 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 117.10199738 58.52199936 Tm [(mito)1(sis.)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 149.897995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 154.397995 58.52199936 Tm [(CDC25B)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 189.49699402 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 193.99699402 58.52199936 Tm [(shut)1(tles)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 227.62399292 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 232.12399292 58.52199936 Tm [(b)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(etw)1(e)-1(en)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 31.3239994 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 35.82400131 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 49.82500076 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 54.32500076 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 87.14299774 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 91.64299774 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 107.91999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 112.41999817 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 126.42099762 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 130.92100525 74.12200165 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 174.98899841 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 179.48899841 74.12200165 Tm [(due)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 195.897995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 200.397995 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 209.4730072 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 213.9730072 74.12200165 Tm [(nuc)-1(le)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ar)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 8.41100025 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 12.91100025 89.72200012 Tm [(localizat)1(ion)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 61.72100067 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 66.22100067 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 82.4980011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 86.9980011 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 118.51599884 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 123.01599884 89.72200012 Tm [(expor)1(t)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 150.94299316 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 155.44299316 89.72200012 Tm [(signals.)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 187.00900269 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 191.50900269 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 207.31599426 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 211.81599426 89.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(n)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 5.546 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 10.04599953 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 16.60700035 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 21.10700035 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 52.625 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 57.125 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 65.06600189 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 69.56600189 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 83.56700134 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 88.06700134 105.3219986 Tm [(M)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 96.86000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 101.36000061 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 117.63700104 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 122.13700104 105.3219986 Tm [(G1)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 134.10800171 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 138.60800171 105.3219986 Tm [(ph)1(ases)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 168.31100464 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 172.81100464 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 181.65299988 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 186.15299988 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 200.15400696 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 204.65400696 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 219.06399536 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 223.56399536 105.3219986 Tm [(cy)-1(cl)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 25.88299942 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 30.38299942 120.92199707 Tm [(moves)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 58.5340004 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 63.0340004 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 72.10900116 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 76.60900116 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 90.61000061 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 95.11000061 120.92199707 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 139.17799377 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 143.67799377 120.92199707 Tm [(during)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 172.11500549 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 176.61500549 120.92199707 Tm [(S)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 181.80900574 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 186.30900574 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 202.58599854 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 207.08599854 120.92199707 Tm [(G2.)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 221.2230072 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 175.07499695 0.75 l 175.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.07499695 -0.25 l 176.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 217 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 218 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.82499695 0.75 m 422.375 0.75 l 422.375 16.35000038 l 175.82499695 16.35000038 l h f* Q q 1 0 0 1 175.44999695 0 cm -0.625 -0.25 m 247.92500305 -0.25 l 247.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 219 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 175.07499695 0.75 l 175.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.07499695 -0.25 l 176.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 221 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 226 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.82499695 0.75 m 422.375 0.75 l 422.375 16.35000038 l 175.82499695 16.35000038 l h f* Q q 1 0 0 1 175.44999695 0 cm -0.625 -0.25 m 247.92500305 -0.25 l 247.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 227 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDC25B)-1(\(Ph)1(osph)1(o-Ser3)-1(53\))] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 112.52200317 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 175.07499695 0.75 l 175.07499695 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 176.07499695 -0.25 l 176.07499695 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 229 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 230 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.82499695 0.75 m 422.375 0.75 l 422.375 31.95000076 l 175.82499695 31.95000076 l h f* Q q 1 0 0 1 175.44999695 0 cm -0.625 -0.25 m 247.92500305 -0.25 l 247.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 231 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(ser)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ine)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 13.04699993 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 17.54700089 27.3220005 Tm [(35)-1(3\(R-R-)1(S\(p\)-V-)1(T)-1(\))] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 94.91699982 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 99.41699982 27.3220005 Tm [(derived)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 131.69900513 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 136.19900513 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 156.91000366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 161.41000366 27.3220005 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 192.86999512 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 197.36999512 27.3220005 Tm [(CDC25B)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 232.46899414 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 236.96899414 27.3220005 Tm [(.)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 239.13600159 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 175.07499695 0.75 l 175.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.07499695 -0.25 l 176.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 258 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 261 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.82499695 0.75 m 422.375 0.75 l 422.375 16.35000038 l 175.82499695 16.35000038 l h f* Q q 1 0 0 1 175.44999695 0 cm -0.625 -0.25 m 247.92500305 -0.25 l 247.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 262 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ce)-1(ll)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 14.40999985 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 18.90999985 11.72200012 Tm [(division)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 52.00999832 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 56.50999832 11.72200012 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 77.80200195 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 82.30200195 11.72200012 Tm [(25)-1(B)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 98.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.44999695 0.75 m 175.44999695 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.44999695 126.30000305 m 175.44999695 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.44999695 142.65000916 m 175.44999695 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.44999695 159.00001526 m 175.44999695 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.44999695 190.95001221 m 175.44999695 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.375 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.375 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.375 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 190.57501221 m 422.375 190.57501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.92501831 m 423.125 206.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 120 0 R/Length 28332>>stream
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