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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 22 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 48.32600021 23.67700005 Tm 0 Tr [(CD)-1(C25B)1(\(Pho)1(sph)1(o-Ser)-1(3)1(23\))] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 282.85998535 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 393.29998779 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -22 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -22 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 30.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 41 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 64.625 61.9640007 Tm [(CDC)-1(2)1(5B\(Pho)-1(sph)-1(o-S)-1(e)1(r323)1(\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 175.04899597 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 227.54899597 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.04901123 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CDC25B\(Phos)-1(pho)-1(-Ser)1(323\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.15800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.53199768 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.09100342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.46499634 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.26098633 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ce)1(l)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48400116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.85800171 12.82499981 Tm [(di)-1(visi)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.5059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.87999725 12.82499981 Tm [(cy)1(cl)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.52099609 12.82499981 Tm [(25B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.87600708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDC)-1(2)1(5B\(Pho)-1(sph)-1(o-S)-1(e)1(r323)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.42399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 167.0249939 -0.25 l 167.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 166.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 166.7749939 172.3500061 l h f* Q q 1 0 0 1 166.3999939 0 cm -0.625 -0.25 m 257.0249939 -0.25 l 257.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(CDC25B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.09899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.59899902 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.15999985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.65999985 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.63499832 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.13499832 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.39900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.89900208 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.74099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.24099731 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.24200439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.74200439 11.72200012 Tm [(CDC25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.69400024 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.77600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.27600098 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.11799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.61799622 11.72200012 Tm [(ph)1(osph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ta)1(se)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.93300056 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.43300056 27.3220005 Tm [(CDC25B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.5320015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.03199768 27.3220005 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.59200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.09200287 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.09300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.59300232 27.3220005 Tm [(cy)-1(clin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.71899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.21899414 27.3220005 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.24499512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.74499512 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.83299255 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.33299255 27.3220005 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(DC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.15399933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.65399933 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.16600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.66600037 42.92200089 Tm [(removing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.78600311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.28600311 42.92200089 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.46700287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.96700287 42.92200089 Tm [(ph)1(osph)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.86799622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.36799622 42.92200089 Tm [(gr)1(oups)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.74299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.24299622 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.52000427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.02000427 42.92200089 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.76800537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.26800537 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.82899475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.32899475 42.92200089 Tm [(req)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(uire)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.24099922 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.74099922 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.01900101 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.51900101 58.52199936 Tm [(en)-1(t)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.72499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.22499847 58.52199936 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.24099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.74099731 58.52199936 Tm [(mito)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.53700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.03700256 58.52199936 Tm [(CDC25B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.13600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.63600159 58.52199936 Tm [(shut)1(tles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.26300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.76300049 58.52199936 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.83500671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.31900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.81900024 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.09600067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.59600067 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.59700012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.09700012 74.12200165 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.16499329 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.66499329 74.12200165 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.07400513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.57400513 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.64900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.14900208 74.12200165 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.66700745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.16700745 74.12200165 Tm [(localiza)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(tio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.01600075 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.79299927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.29299927 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.81099701 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31099701 89.72200012 Tm [(expor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.23799896 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.73799896 89.72200012 Tm [(signals.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.30400085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.80400085 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.61099243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.11099243 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.41799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.91799927 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.47900391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.97900391 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.49699402 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.44199944 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.94199944 105.3219986 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.73500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.23500061 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51200104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01200104 105.3219986 Tm [(G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.98300171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.48300171 105.3219986 Tm [(ph)1(ases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.18599701 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.68599701 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.52799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.02799988 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.02900696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.52900696 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.93899536 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.43899536 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.73100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.23100281 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.50799561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.00799561 105.3219986 Tm [(moves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.15899658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.57600021 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.07600021 120.92199707 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.14399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.64399719 120.92199707 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.08100128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.58100128 120.92199707 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.77500153 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.27500153 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.55200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.05200195 120.92199707 Tm [(G2.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.18899536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.68899536 120.92199707 Tm [(CDC25B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.78799438 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.28799438 120.92199707 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.97000122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.47000122 120.92199707 Tm [(oncog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(en)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.56100082 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.06100082 136.52200317 Tm [(pro)1(perties,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.44499969 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.94499969 136.52200317 Tm [(alt)1(hough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.77500153 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.27500153 136.52200317 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.18900299 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.68899536 136.52200317 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.34899902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.84899902 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.78999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.28999329 136.52200317 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.77999878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.27999878 136.52200317 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.98199463 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.48199463 136.52200317 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 152.12199402 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.26199913 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.76200104 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.26900101 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.76900101 152.12199402 Tm [(determine)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.93199921 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.43199921 152.12199402 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.16400146 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.66400146 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.58599854 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.08599854 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.65600586 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.15600586 152.12199402 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.39299965 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.89299965 167.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.4090004 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.9090004 167.72200012 Tm [(exist.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.65799713 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 0.75 m 166.3999939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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