%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.81199646 23.67700005 Tm 0 g [(ATF7)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 144.78399658 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 321.48800659 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(ATF7)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 81.71299744 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.71299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATF7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.33799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.71199799 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.91400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.28800201 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.64199829 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.11599731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(ATFA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09200287 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(activat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.98500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.48500061 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.06900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.56900024 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.68800354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.18800354 11.72200012 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.46600342 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ATFA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.60499954 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P17)-1(54)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(42)-1(36)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 149.32499695 16.35000038 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 148.57499695 0.75 l 148.57499695 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 149.57499695 -0.25 l 149.57499695 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.32499695 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 149.32499695 109.94999695 l h f* Q q 1 0 0 1 148.94999695 0 cm -0.625 -0.25 m 278.2250061 -0.25 l 278.2250061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.80599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.30599976 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.26699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.76699829 11.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.6740036 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.1740036 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.11499786 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.61500549 11.72200012 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.29100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.79100037 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.20100403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.70100403 11.72200012 Tm [(signaling.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.79899597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.29899597 11.72200012 Tm [(Bi)-1(nd)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.80999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.30999756 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.31100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cAMP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.14599991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.64599991 27.3220005 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.64299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.14299774 27.3220005 Tm [(ele)-1(ment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.18900299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.68900299 27.3220005 Tm [(\(CRE\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.54499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.04499817 27.3220005 Tm [(\(conse)-1(nsus:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.69400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.19400024 27.3220005 Tm [(5')-1(-)1(GTGAC)1(GT[AG])] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [([AG)1(]-3')-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.68799973 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.18799973 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.1629982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.6629982 42.92200089 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.51000214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.01000214 42.92200089 Tm [(present)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.47200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.97200012 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.91299438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.41299438 42.92200089 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.13000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.63000488 42.92200089 Tm [(viral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.55499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.05499268 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.33200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.83200073 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.59399414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.09399414 42.92200089 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mot)1(e)-1(rs)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.38299942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.88299942 58.52199936 Tm [(Activa)1(tor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.68699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.18699646 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.02899933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.52899933 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.52999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.02999878 58.52199936 Tm [(NF-ELA)1(M)-1(1/delta-)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.6499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1499939 58.52199936 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.17100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.67100525 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.51300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.01300049 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.01400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.51400757 58.52199936 Tm [(E-)1(se)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ec)-1(t)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.91399956 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.41399956 74.12200165 Tm [(pro)1(moter.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.53800201 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.03800201 74.12200165 Tm [(Has)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.13999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.63999939 74.12200165 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.90799713 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.40799713 74.12200165 Tm [(intrinsic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.15400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.65400696 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.60800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.10800171 74.12200165 Tm [(activit)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.7460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.2460022 74.12200165 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.89300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.56000137 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.06000137 89.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.64399719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.14399719 89.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.41200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.91200256 89.72200012 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.61399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.11399841 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.95599365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.45599365 89.72200012 Tm [(JUN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.05599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.55599976 89.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.71400452 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.21400452 89.72200012 Tm [(FOS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.52400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.02400208 89.72200012 Tm [(heterod)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ime)-1(r)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.70400047 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.20400047 105.3219986 Tm [(Also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31900024 105.3219986 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.35299683 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.85299683 105.3219986 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.2990036 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.7990036 105.3219986 Tm [(TRE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.78199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.28199768 105.3219986 Tm [(pro)1(moter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.23899841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.73899841 105.3219986 Tm [(seque)-1(nce)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.7519989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.2519989 105.3219986 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.55200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.05200195 105.3219986 Tm [(hetero)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 0.75 m 148.94999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 17.10000038 m 148.94999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 33.45000076 m 148.94999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 49.80000305 m 148.94999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 66.15000153 m 148.94999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 82.5 m 148.94999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 98.84999847 m 148.94999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.94999695 115.19999695 m 148.94999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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