%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(DSC3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 102.23799896 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 212.67799377 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 223.67799377 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -25 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -1.375 61.9640007 Tm [(DS)-1(C3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 23.45500183 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 75.95500183 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.20500183 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DSC)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.93800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.31199646 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.96200562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.33599854 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.89500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26899719 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.06500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DS)-1(C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.69300079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.06700134 12.82499981 Tm [(DS)-1(C1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.08100128 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.45500183 12.82499981 Tm [(DS)-1(C2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.46899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.84300232 12.82499981 Tm [(DS)-1(C4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.85699463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.23100281 12.82499981 Tm [(CDHF)-1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.78700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.16099548 12.82499981 Tm [(HT-)-1(CP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.05700684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DS)-1(C3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.20500183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001100120013000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700130025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 148.7749939 0.75 l 148.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 149.7749939 -0.25 l 149.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 149.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 149.5249939 172.3500061 l h f* Q q 1 0 0 1 149.1499939 0 cm -0.625 -0.25 m 274.2749939 -0.25 l 274.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(calc)-1(ium-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.32998657 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(glyc)-1(o)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.45700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.95700073 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.17900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.67900085 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.23999786 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.73999786 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.71499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.21499634 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.47900391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.97900391 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.82099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.32099915 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.32200623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.82200623 27.3220005 Tm [(desmocollin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.97200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.47200012 27.3220005 Tm [(subf)1(ami)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.15899992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.6590004 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.50099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.00099945 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.0019989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.5019989 42.92200089 Tm [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.77200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.27200317 42.92200089 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.522995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.022995 42.92200089 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.10299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.60299683 42.92200089 Tm [(desmoso)1(mal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.47799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97799683 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.05999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(members,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.59600067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.09600067 58.52199936 Tm [(along)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.48999786 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.98999786 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.38600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.88600159 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.88700104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.38700104 58.52199936 Tm [(desmog)1(le)-1(ins,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.10299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.60299683 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.1210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.6210022 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.31100464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.81100464 58.52199936 Tm [(prima)1(rily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.78900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 74.12200165 Tm [(epith)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.85100174 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.35100174 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.92700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.42700195 74.12200165 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.72399902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.22399902 74.12200165 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.98899841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.48899841 74.12200165 Tm [(constitut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.54200745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.04200745 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.04299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.54299927 74.12200165 Tm [(ad)1(hesive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.31399536 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.81399536 74.12200165 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10700035 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.4489994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.9489994 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.95000076 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.45000076 89.72200012 Tm [(desmoso)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.06099701 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.56099701 89.72200012 Tm [(ce)-1(ll-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.27400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.77400208 89.72200012 Tm [(jun)-1(ctio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.79800415 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.29800415 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.57499695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.07499695 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.59300232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.09300232 89.72200012 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.63400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.13400269 89.72200012 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.06800079 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.56800079 105.3219986 Tm [(ad)1(hesion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.77600098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.27600098 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.5530014 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.0530014 105.3219986 Tm [(desmoso)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.66400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.16400146 105.3219986 Tm [(fo)1(rmatio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.03199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.53199768 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.33900452 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.83900452 105.3219986 Tm [(desmoso)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.3029995 120.92199707 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.38499832 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.88499832 120.92199707 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.31500244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.81500244 120.92199707 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.33300018 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.83300018 120.92199707 Tm [(arr)1(anged)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.82099915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.32099915 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.26199341 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.76199341 120.92199707 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.94299316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.44299316 120.92199707 Tm [(cl)-1(ust)1(e)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.125 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.625 120.92199707 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.89300537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.39300537 120.92199707 Tm [(chro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(moso)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.58200073 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.08200073 136.52200317 Tm [(18)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.80400085 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.30400085 136.52200317 Tm [(occ)-1(upying)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.80699921 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.30699921 136.52200317 Tm [(less)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.13999939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.63999939 136.52200317 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.05499268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.55499268 136.52200317 Tm [(65)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.38800049 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.88800049 136.52200317 Tm [(kb)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.53599548 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.03599548 136.52200317 Tm [(combine)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.42300415 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.92300415 136.52200317 Tm [(Mutat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.82900047 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.32900047 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.27000046 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.77000046 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.22600174 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.72600174 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.24199677 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.74199677 152.12199402 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.26000214 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.76000214 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.73500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.23500061 152.12199402 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.54100037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04100037 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.88299561 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.38299561 152.12199402 Tm [(hypo)1(trichosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.84599304 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.34599304 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.6230011 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.1230011 152.12199402 Tm [(rec)-1(urre)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 167.72200012 Tm [(skin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.90599823 167.72200012 Tm [(vesic)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.47799683 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.97799683 167.72200012 Tm [(diso)1(rder.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.91999817 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.41999817 167.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.227005 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.727005 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.03399658 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.53399658 167.72200012 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.56799316 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.06799316 167.72200012 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.90899658 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.40899658 167.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.55000305 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.05000305 167.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.57099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.07099915 167.72200012 Tm [(auto)1(a)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.1499939 0.75 m 149.1499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>