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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.36000061 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.03599548 23.67700005 Tm 0 Tr [(CD)-1(15)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.5 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.94000244 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CD151)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.77400208 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.27400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.52400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CD151)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.75700378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.1309967 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.78100586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.15499878 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.71400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.08799744 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.88400269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GP)1(27,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.31199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.68599701 12.82499981 Tm [(MER2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.43299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.80699921 12.82499981 Tm [(RAP)1(H,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.16999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.54400635 12.82499981 Tm [(SF)-1(A1)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.21000671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.58399963 12.82499981 Tm [(PETA-3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.48399353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.85800171 12.82499981 Tm [(TS)-1(P)1(AN2)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.72000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD151)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 169.0249939 172.3500061 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 254.7749939 -0.25 l 254.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.86599731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.36599731 27.3220005 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.64399719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.14399719 27.3220005 Tm [(superfa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.39500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.89500427 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.1519928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.6519928 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.47099304 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.97099304 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.11199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.61199951 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.61300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.11300659 27.3220005 Tm [(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tr)1(aspa)1(n)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.13999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.63999939 42.92200089 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.88800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.38800049 42.92200089 Tm [(Most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.42199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.92199707 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.76399994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.26399994 42.92200089 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.53700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.03700256 42.92200089 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.46699524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.96699524 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.48500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.98500061 42.92200089 Tm [(ce)-1(ll-surf)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ace)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.59399986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.09399986 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.56700134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.06700134 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.28900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.78900146 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.30699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.80699921 58.52199936 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.33999634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.83999634 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.352005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.852005 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.85299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.35299683 58.52199936 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.08200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.58200073 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.42399597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.8239994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.3239994 74.12200165 Tm [(hydro)1(pho)1(bic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.21199799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.71199799 74.12200165 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.87200165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.37200165 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.17900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.67900085 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.1519928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.6519928 74.12200165 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.7769928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.2769928 74.12200165 Tm [(sign)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 89.72200012 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.1780014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.6780014 89.72200012 Tm [(eve)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.68000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.18000031 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.40200043 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.90200043 89.72200012 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.78300476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.28300476 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.25799561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75799561 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.41799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.91799927 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.85899353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.35899353 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.36000061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.86000061 89.72200012 Tm [(regulat)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.61000061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.11000061 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.52000046 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.02000046 105.3219986 Tm [(development,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.18399811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.68399811 105.3219986 Tm [(activat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.80099487 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.30099487 105.3219986 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.21699524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.71699524 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.9940033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.4940033 105.3219986 Tm [(mot)1(il)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(y.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.92999983 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.43000031 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.69199944 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.19200134 120.92199707 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.6989975 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.1989975 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.5059967 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.0059967 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.56700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.06700134 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.04199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.54200745 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.95199585 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.45199585 120.92199707 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.31500244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.81500244 120.92199707 Tm [(glyc)-1(o)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.27200317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.28300095 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.78300095 136.52200317 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.60200119 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.10199738 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.17700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.67700195 136.52200317 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.15599823 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.65599823 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.05200195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.55200195 136.52200317 Tm [(integrins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.25300598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.75300598 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.02999878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.52999878 136.52200317 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.68899536 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.18899536 136.52200317 Tm [(tr)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nsmem)-1(b)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.49599838 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.99599838 152.12199402 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.27400208 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.77400208 152.12199402 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85800171 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.35800171 152.12199402 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.99699402 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.49699402 152.12199402 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.4960022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.9960022 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.55700684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.05700684 152.12199402 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.42599487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.92599487 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.86700439 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.76199913 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.26200104 167.72200012 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.39199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.89199829 167.72200012 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.74199677 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.24199677 167.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.6519928 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.1519928 167.72200012 Tm [(ad)1(hesion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.36000061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.86000061 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.13699341 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.63699341 167.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.80799866 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.30799866 167.72200012 Tm [(reg)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 0.75 m 168.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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